Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq

Oncogenic driver mutations are identified in single cells by a transposon-based sequencing method. A central challenge in oncology is how to kill tumors containing heterogeneous cell populations defined by different combinations of mutated genes. Identifying these mutated genes and understanding how...

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Veröffentlicht in:	Nature biotechnology 2016-09, Vol.34 (9), p.962-972
Hauptverfasser:	Mann, Karen M, Newberg, Justin Y, Black, Michael A, Jones, Devin J, Amaya-Manzanares, Felipe, Guzman-Rojas, Liliana, Kodama, Takahiro, Ward, Jerrold M, Rust, Alistair G, van der Weyden, Louise, Yew, Christopher Chin Kuan, Waters, Jill L, Leung, Marco L, Rogers, Keith, Rogers, Susan M, McNoe, Leslie A, Selvanesan, Luxmanan, Navin, Nicholas, Jenkins, Nancy A, Copeland, Neal G, Mann, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	38/91 45/23 45/47 631/1647/334/1874/345 631/1647/514/2254 631/208/212/2305 631/67/1990/283/1897 631/67/69 64/110 64/60 Agriculture Algorithms Animals Bioinformatics Biomarkers, Tumor - genetics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cancer cells Cells DNA sequencing DNA Transposable Elements DNA, Neoplasm - genetics Female Gene expression Genes, Neoplasm - genetics Genetic aspects Health aspects Heterogeneity High-Throughput Nucleotide Sequencing - methods In Situ Hybridization - methods Leukemia Leukemia, Myeloid - genetics Leukemia, Myeloid - pathology Life Sciences Male Methods Mice Mutagenesis, Insertional - genetics Myeloid leukemia Neoplasm Proteins - genetics Oncology Sequence Analysis, DNA - methods Software Subpopulations Transposases - genetics Tumors
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