Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

In hemolytic diseases, such as sickle cell disease (SCD), intravascular hemolysis results in the release of hemoglobin, heme, and heme-loaded membrane microvesicles in the bloodstream. Intravascular hemolysis is thus associated with inflammation and organ injury. Complement system can be activated b...

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Veröffentlicht in:	JCI insight 2018-06, Vol.3 (12)
Hauptverfasser:	Merle, Nicolas S, Grunenwald, Anne, Rajaratnam, Helena, Gnemmi, Viviane, Frimat, Marie, Figueres, Marie-Lucile, Knockaert, Samantha, Bouzekri, Sanah, Charue, Dominique, Noe, Remi, Robe-Rybkine, Tania, Le-Hoang, Marie, Brinkman, Nathan, Gentinetta, Thomas, Edler, Monika, Petrillo, Sara, Tolosano, Emanuela, Miescher, Sylvia, Le Jeune, Sylvain, Houillier, Pascal, Chauvet, Sophie, Rabant, Marion, Dimitrov, Jordan D, Fremeaux-Bacchi, Veronique, Blanc-Brude, Olivier P, Roumenina, Lubka T
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences
Online-Zugang:	Volltext
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