Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors
In the human body, 50–70 billion cells die every day, resulting in the generation of a large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies in regulating tissue homeostasis remains unclear. In this study, we used Fas-deficient MRL/ lpr and Caspase 3 −/− mice to...
Gespeichert in:
| Veröffentlicht in: | Cell research 2018-09, Vol.28 (9), p.918-933 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 933 |
|---|---|
| container_issue | 9 |
| container_start_page | 918 |
| container_title | Cell research |
| container_volume | 28 |
| creator | Liu, Dawei Kou, Xiaoxing Chen, Chider Liu, Shiyu Liu, Yao Yu, Wenjing Yu, Tingting Yang, Ruili Wang, Runci Zhou, Yanheng Shi, Songtao |
| description | In the human body, 50–70 billion cells die every day, resulting in the generation of a large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies in regulating tissue homeostasis remains unclear. In this study, we used Fas-deficient MRL/
lpr
and
Caspase 3
−/−
mice to show that reduction of apoptotic body formation significantly impaired the self-renewal and osteo-/adipo-genic differentiation of bone marrow mesenchymal stem cells (MSCs). Systemic infusion of exogenous apoptotic bodies rescued the MSC impairment and also ameliorated the osteopenia phenotype in MRL/
lpr
,
Caspase 3
−/−
and ovariectomized (OVX) mice. Mechanistically, we showed that MSCs were able to engulf apoptotic bodies via integrin αvβ3 and reuse apoptotic body-derived ubiquitin ligase RNF146 and miR-328-3p to inhibit Axin1 and thereby activate the Wnt/β-catenin pathway. Moreover, we used a parabiosis mouse model to reveal that apoptotic bodies participated in the circulation to regulate distant MSCs. This study identifies a previously unknown role of apoptotic bodies in maintaining MSC and bone homeostasis in both physiological and pathological contexts and implies the potential use of apoptotic bodies to treat osteoporosis. |
| doi_str_mv | 10.1038/s41422-018-0070-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6123409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2099432626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c584t-17de0c024d517216b781529b9f7806eedcc45fb6ecd4df38656640b82417bf493</originalsourceid><addsrcrecordid>eNp1kcuKFTEQhhtRnIs-gBsJuHHTWrl0OmcjyEEdYcCNrkM6XT0nQydpk_TAvMM8tGnPOF7ARZGQfPXX5W-aFxTeUODqbRZUMNYCVS1ADy171JzSXqi2V1w9rncA2oIEdtKc5XwNwDrR0afNCQfg0FF12tztXbLrbIoLV8QscSmxOEuGODrMxBsXSg3iMWOwh1tvZpILemJxnskheoy5mOwyMWEkxuPsYjIFSX3GuGBwhtzUKMmEPGFKWxm_zsUtM_4UqbUTmYwtMeVnzZPJzBmf35_nzbePH77uL9rLL58-799ftrZTorS0HxEsMDF2tGdUDr2iHdsNu6lXIBFHa0U3DRLtKMaJK9lJKWBQTNB-mMSOnzfvjrrLOviKY6j9zXpJzpt0q6Nx-u-f4A76Kt5oSRkXsAm8vhdI8fuKuWjv8jaNCRjXrBn0nLNtwxV99Q96HdcU6niV2u0EZ5LJStEjZVPMOeH00AwFvXmtj17r6rXevNas5rz8c4qHjF_mVoAdgbxse8f0u_T_VX8AXoy4qg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2099432626</pqid></control><display><type>article</type><title>Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Liu, Dawei ; Kou, Xiaoxing ; Chen, Chider ; Liu, Shiyu ; Liu, Yao ; Yu, Wenjing ; Yu, Tingting ; Yang, Ruili ; Wang, Runci ; Zhou, Yanheng ; Shi, Songtao</creator><creatorcontrib>Liu, Dawei ; Kou, Xiaoxing ; Chen, Chider ; Liu, Shiyu ; Liu, Yao ; Yu, Wenjing ; Yu, Tingting ; Yang, Ruili ; Wang, Runci ; Zhou, Yanheng ; Shi, Songtao</creatorcontrib><description>In the human body, 50–70 billion cells die every day, resulting in the generation of a large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies in regulating tissue homeostasis remains unclear. In this study, we used Fas-deficient MRL/
lpr
and
Caspase 3
−/−
mice to show that reduction of apoptotic body formation significantly impaired the self-renewal and osteo-/adipo-genic differentiation of bone marrow mesenchymal stem cells (MSCs). Systemic infusion of exogenous apoptotic bodies rescued the MSC impairment and also ameliorated the osteopenia phenotype in MRL/
lpr
,
Caspase 3
−/−
and ovariectomized (OVX) mice. Mechanistically, we showed that MSCs were able to engulf apoptotic bodies via integrin αvβ3 and reuse apoptotic body-derived ubiquitin ligase RNF146 and miR-328-3p to inhibit Axin1 and thereby activate the Wnt/β-catenin pathway. Moreover, we used a parabiosis mouse model to reveal that apoptotic bodies participated in the circulation to regulate distant MSCs. This study identifies a previously unknown role of apoptotic bodies in maintaining MSC and bone homeostasis in both physiological and pathological contexts and implies the potential use of apoptotic bodies to treat osteoporosis.</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/s41422-018-0070-2</identifier><identifier>PMID: 30030518</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/100 ; 13/2 ; 13/31 ; 13/51 ; 13/89 ; 14/19 ; 631/532/2074 ; 631/80/82/23 ; 64/110 ; 64/60 ; 82/80 ; Animals ; Apoptosis ; Biocompatibility ; Biomedical and Life Sciences ; Bone Diseases, Metabolic - metabolism ; Bone Diseases, Metabolic - pathology ; Bone marrow ; Bone turnover ; Caspase ; Caspase-3 ; Cell Biology ; Cell Differentiation ; Cell Proliferation ; Cell self-renewal ; Extracellular Vesicles - metabolism ; Female ; Homeostasis ; Life Sciences ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - metabolism ; Mesenchyme ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Knockout ; Osteopenia ; Osteoporosis ; Ovariectomy ; Parabiosis ; Phenotypes ; Stem cell transplantation ; Stem cells ; Ubiquitin ; Ubiquitin-protein ligase ; Wnt protein ; β-Catenin</subject><ispartof>Cell research, 2018-09, Vol.28 (9), p.918-933</ispartof><rights>IBCB, SIBS, CAS 2018</rights><rights>Copyright Nature Publishing Group Sep 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-17de0c024d517216b781529b9f7806eedcc45fb6ecd4df38656640b82417bf493</citedby><cites>FETCH-LOGICAL-c584t-17de0c024d517216b781529b9f7806eedcc45fb6ecd4df38656640b82417bf493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123409/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123409/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30030518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Dawei</creatorcontrib><creatorcontrib>Kou, Xiaoxing</creatorcontrib><creatorcontrib>Chen, Chider</creatorcontrib><creatorcontrib>Liu, Shiyu</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Yu, Wenjing</creatorcontrib><creatorcontrib>Yu, Tingting</creatorcontrib><creatorcontrib>Yang, Ruili</creatorcontrib><creatorcontrib>Wang, Runci</creatorcontrib><creatorcontrib>Zhou, Yanheng</creatorcontrib><creatorcontrib>Shi, Songtao</creatorcontrib><title>Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Res</addtitle><description>In the human body, 50–70 billion cells die every day, resulting in the generation of a large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies in regulating tissue homeostasis remains unclear. In this study, we used Fas-deficient MRL/
lpr
and
Caspase 3
−/−
mice to show that reduction of apoptotic body formation significantly impaired the self-renewal and osteo-/adipo-genic differentiation of bone marrow mesenchymal stem cells (MSCs). Systemic infusion of exogenous apoptotic bodies rescued the MSC impairment and also ameliorated the osteopenia phenotype in MRL/
lpr
,
Caspase 3
−/−
and ovariectomized (OVX) mice. Mechanistically, we showed that MSCs were able to engulf apoptotic bodies via integrin αvβ3 and reuse apoptotic body-derived ubiquitin ligase RNF146 and miR-328-3p to inhibit Axin1 and thereby activate the Wnt/β-catenin pathway. Moreover, we used a parabiosis mouse model to reveal that apoptotic bodies participated in the circulation to regulate distant MSCs. This study identifies a previously unknown role of apoptotic bodies in maintaining MSC and bone homeostasis in both physiological and pathological contexts and implies the potential use of apoptotic bodies to treat osteoporosis.</description><subject>13/100</subject><subject>13/2</subject><subject>13/31</subject><subject>13/51</subject><subject>13/89</subject><subject>14/19</subject><subject>631/532/2074</subject><subject>631/80/82/23</subject><subject>64/110</subject><subject>64/60</subject><subject>82/80</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Bone Diseases, Metabolic - metabolism</subject><subject>Bone Diseases, Metabolic - pathology</subject><subject>Bone marrow</subject><subject>Bone turnover</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cell self-renewal</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Female</subject><subject>Homeostasis</subject><subject>Life Sciences</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Osteopenia</subject><subject>Osteoporosis</subject><subject>Ovariectomy</subject><subject>Parabiosis</subject><subject>Phenotypes</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Ubiquitin</subject><subject>Ubiquitin-protein ligase</subject><subject>Wnt protein</subject><subject>β-Catenin</subject><issn>1001-0602</issn><issn>1748-7838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcuKFTEQhhtRnIs-gBsJuHHTWrl0OmcjyEEdYcCNrkM6XT0nQydpk_TAvMM8tGnPOF7ARZGQfPXX5W-aFxTeUODqbRZUMNYCVS1ADy171JzSXqi2V1w9rncA2oIEdtKc5XwNwDrR0afNCQfg0FF12tztXbLrbIoLV8QscSmxOEuGODrMxBsXSg3iMWOwh1tvZpILemJxnskheoy5mOwyMWEkxuPsYjIFSX3GuGBwhtzUKMmEPGFKWxm_zsUtM_4UqbUTmYwtMeVnzZPJzBmf35_nzbePH77uL9rLL58-799ftrZTorS0HxEsMDF2tGdUDr2iHdsNu6lXIBFHa0U3DRLtKMaJK9lJKWBQTNB-mMSOnzfvjrrLOviKY6j9zXpJzpt0q6Nx-u-f4A76Kt5oSRkXsAm8vhdI8fuKuWjv8jaNCRjXrBn0nLNtwxV99Q96HdcU6niV2u0EZ5LJStEjZVPMOeH00AwFvXmtj17r6rXevNas5rz8c4qHjF_mVoAdgbxse8f0u_T_VX8AXoy4qg</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Liu, Dawei</creator><creator>Kou, Xiaoxing</creator><creator>Chen, Chider</creator><creator>Liu, Shiyu</creator><creator>Liu, Yao</creator><creator>Yu, Wenjing</creator><creator>Yu, Tingting</creator><creator>Yang, Ruili</creator><creator>Wang, Runci</creator><creator>Zhou, Yanheng</creator><creator>Shi, Songtao</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors</title><author>Liu, Dawei ; Kou, Xiaoxing ; Chen, Chider ; Liu, Shiyu ; Liu, Yao ; Yu, Wenjing ; Yu, Tingting ; Yang, Ruili ; Wang, Runci ; Zhou, Yanheng ; Shi, Songtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-17de0c024d517216b781529b9f7806eedcc45fb6ecd4df38656640b82417bf493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/100</topic><topic>13/2</topic><topic>13/31</topic><topic>13/51</topic><topic>13/89</topic><topic>14/19</topic><topic>631/532/2074</topic><topic>631/80/82/23</topic><topic>64/110</topic><topic>64/60</topic><topic>82/80</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biocompatibility</topic><topic>Biomedical and Life Sciences</topic><topic>Bone Diseases, Metabolic - metabolism</topic><topic>Bone Diseases, Metabolic - pathology</topic><topic>Bone marrow</topic><topic>Bone turnover</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Cell self-renewal</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Female</topic><topic>Homeostasis</topic><topic>Life Sciences</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mesenchymal Stem Cells - metabolism</topic><topic>Mesenchyme</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Osteopenia</topic><topic>Osteoporosis</topic><topic>Ovariectomy</topic><topic>Parabiosis</topic><topic>Phenotypes</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Ubiquitin</topic><topic>Ubiquitin-protein ligase</topic><topic>Wnt protein</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Dawei</creatorcontrib><creatorcontrib>Kou, Xiaoxing</creatorcontrib><creatorcontrib>Chen, Chider</creatorcontrib><creatorcontrib>Liu, Shiyu</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Yu, Wenjing</creatorcontrib><creatorcontrib>Yu, Tingting</creatorcontrib><creatorcontrib>Yang, Ruili</creatorcontrib><creatorcontrib>Wang, Runci</creatorcontrib><creatorcontrib>Zhou, Yanheng</creatorcontrib><creatorcontrib>Shi, Songtao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Dawei</au><au>Kou, Xiaoxing</au><au>Chen, Chider</au><au>Liu, Shiyu</au><au>Liu, Yao</au><au>Yu, Wenjing</au><au>Yu, Tingting</au><au>Yang, Ruili</au><au>Wang, Runci</au><au>Zhou, Yanheng</au><au>Shi, Songtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors</atitle><jtitle>Cell research</jtitle><stitle>Cell Res</stitle><addtitle>Cell Res</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>28</volume><issue>9</issue><spage>918</spage><epage>933</epage><pages>918-933</pages><issn>1001-0602</issn><eissn>1748-7838</eissn><abstract>In the human body, 50–70 billion cells die every day, resulting in the generation of a large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies in regulating tissue homeostasis remains unclear. In this study, we used Fas-deficient MRL/
lpr
and
Caspase 3
−/−
mice to show that reduction of apoptotic body formation significantly impaired the self-renewal and osteo-/adipo-genic differentiation of bone marrow mesenchymal stem cells (MSCs). Systemic infusion of exogenous apoptotic bodies rescued the MSC impairment and also ameliorated the osteopenia phenotype in MRL/
lpr
,
Caspase 3
−/−
and ovariectomized (OVX) mice. Mechanistically, we showed that MSCs were able to engulf apoptotic bodies via integrin αvβ3 and reuse apoptotic body-derived ubiquitin ligase RNF146 and miR-328-3p to inhibit Axin1 and thereby activate the Wnt/β-catenin pathway. Moreover, we used a parabiosis mouse model to reveal that apoptotic bodies participated in the circulation to regulate distant MSCs. This study identifies a previously unknown role of apoptotic bodies in maintaining MSC and bone homeostasis in both physiological and pathological contexts and implies the potential use of apoptotic bodies to treat osteoporosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30030518</pmid><doi>10.1038/s41422-018-0070-2</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1001-0602 |
| ispartof | Cell research, 2018-09, Vol.28 (9), p.918-933 |
| issn | 1001-0602 1748-7838 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6123409 |
| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 13/100 13/2 13/31 13/51 13/89 14/19 631/532/2074 631/80/82/23 64/110 64/60 82/80 Animals Apoptosis Biocompatibility Biomedical and Life Sciences Bone Diseases, Metabolic - metabolism Bone Diseases, Metabolic - pathology Bone marrow Bone turnover Caspase Caspase-3 Cell Biology Cell Differentiation Cell Proliferation Cell self-renewal Extracellular Vesicles - metabolism Female Homeostasis Life Sciences Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Osteopenia Osteoporosis Ovariectomy Parabiosis Phenotypes Stem cell transplantation Stem cells Ubiquitin Ubiquitin-protein ligase Wnt protein β-Catenin |
| title | Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T12%3A17%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20apoptotic%20bodies%20maintain%20mesenchymal%20stem%20cell%20homeostasis%20and%20ameliorate%20osteopenia%20via%20transferring%20multiple%20cellular%20factors&rft.jtitle=Cell%20research&rft.au=Liu,%20Dawei&rft.date=2018-09-01&rft.volume=28&rft.issue=9&rft.spage=918&rft.epage=933&rft.pages=918-933&rft.issn=1001-0602&rft.eissn=1748-7838&rft_id=info:doi/10.1038/s41422-018-0070-2&rft_dat=%3Cproquest_pubme%3E2099432626%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2099432626&rft_id=info:pmid/30030518&rfr_iscdi=true |