Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis
Aims/Introduction Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound amine oxidase highly expressed in mature adipocytes and released into the circulation. VAP‐1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and...
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| Veröffentlicht in: | Journal of diabetes investigation 2018-09, Vol.9 (5), p.1067-1074 |
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| creator | Chang, Yi‐Cheng Hee, Siow‐Wey Lee, Wei‐Jei Li, Hung‐Yuan Chang, Tien‐Jyun Lin, Ming‐Wei Hung, Yi‐Jen Lee, I‐Te Hung, Kuan‐Yi Assimes, Themistocles Knowles, Joshua W Nong, Jiun‐Yi Lee, Po‐Chu Chiu, Yen‐Feng Chuang, Lee‐Ming |
| description | Aims/Introduction
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound amine oxidase highly expressed in mature adipocytes and released into the circulation. VAP‐1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. Here, we aimed to identify the genetic loci for circulating VAP‐1 levels.
Materials and Methods
We carried out a genomic‐wide linkage scan for the quantitative trait locus of circulating VAP‐1 levels in 1,100 Han Chinese individuals from 398 families in the Stanford Asian Pacific Program for Hypertension and Insulin Resistance study. Regional association fine mapping was carried out using additional single‐nucleotide polymorphisms.
Results
The estimated heritability of circulating VAP‐1 levels is high (h2 = 69%). The most significant quantitative trait locus for circulating VAP‐1 was located at 38 cM on chromosome 20, with a maximum empirical logarithm of odds score of 4.11 (P = 6.86 × 10−6) in females. Regional single‐nucleotide polymorphism fine mapping within a 1‐unit support region showed the strongest association signals in the MACRO domain containing 2 (MACROD2) gene in females (P = 5.38 × 10−6). Knockdown of MACROD2 significantly suppressed VAP‐1 expression in human adipocytes, as well as the expression of key adipogenic genes. Furthermore, MACROD2 expression was found to be positively associated with VAP‐1 in human visceral adipose tissue.
Conclusion
MACROD2 is a potential genetic determinant of serum VAP‐1 levels, probably through transcriptional regulation of adipogenesis.
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound aminine oxidase that is highly expressed in mature adipocyte and is released into circulating. VAP‐1 has been strongly implicated in several pathological processes and is an important disease marker as well as therapeutic target for pharmaceutical industry. We conducted the first genome‐wide scan for circulating VAP‐1 levels in a large family cohort. We identified MACROD2 is a qualitative trait loci for circulating VAP‐1. |
| doi_str_mv | 10.1111/jdi.12805 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6123039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1990855315</sourcerecordid><originalsourceid>FETCH-LOGICAL-g3935-2806bda3575b89ce0b7e7c1b1bbe6fa1a1cb34550dda84e41deb2eb06827ccb13</originalsourceid><addsrcrecordid>eNpVUctuFDEQtBCIREsO_ADykcsmfoznwQEp2jwICoqEkrPV9vROHHntwZ7dKLdcufGNfAneJKygLy6rqqvabkLec3bISx3d9e6Qi5apV2RfsIrNORfV6x3m9R45yPmOlZJtW9fNW7InOllXqhX75Oc5hrjC34-_7l2PNFsIdBkTtS7ZtYfJhYFuIG9xotDfYnYx0DHFCV0oXZx63KDPn-i348X3qxNBIVOgY-HD5MDTKUHINrlxKo3lnnDY-paIuCyGbowDhuKa35E3S_AZD17OGbk5O71efJlfXp1fLI4v54PspJqXl9amB6kaZdrOIjMNNpYbbgzWS-DArZGVUqzvoa2w4j0agYbVrWisNVzOyOdn33FtVtjbMmcCr8fkVpAedASn_2eCu9VD3OiaC8nKDDPy8cUgxR9rzJNeuWzRewgY11nzrmOtUpKrIv3wb9Yu5O__F8HRs-DeeXzY8Zzp7W512a1-2q3-enLxBOQfmimcDg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1990855315</pqid></control><display><type>article</type><title>Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Chang, Yi‐Cheng ; Hee, Siow‐Wey ; Lee, Wei‐Jei ; Li, Hung‐Yuan ; Chang, Tien‐Jyun ; Lin, Ming‐Wei ; Hung, Yi‐Jen ; Lee, I‐Te ; Hung, Kuan‐Yi ; Assimes, Themistocles ; Knowles, Joshua W ; Nong, Jiun‐Yi ; Lee, Po‐Chu ; Chiu, Yen‐Feng ; Chuang, Lee‐Ming</creator><creatorcontrib>Chang, Yi‐Cheng ; Hee, Siow‐Wey ; Lee, Wei‐Jei ; Li, Hung‐Yuan ; Chang, Tien‐Jyun ; Lin, Ming‐Wei ; Hung, Yi‐Jen ; Lee, I‐Te ; Hung, Kuan‐Yi ; Assimes, Themistocles ; Knowles, Joshua W ; Nong, Jiun‐Yi ; Lee, Po‐Chu ; Chiu, Yen‐Feng ; Chuang, Lee‐Ming</creatorcontrib><description>Aims/Introduction
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound amine oxidase highly expressed in mature adipocytes and released into the circulation. VAP‐1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. Here, we aimed to identify the genetic loci for circulating VAP‐1 levels.
Materials and Methods
We carried out a genomic‐wide linkage scan for the quantitative trait locus of circulating VAP‐1 levels in 1,100 Han Chinese individuals from 398 families in the Stanford Asian Pacific Program for Hypertension and Insulin Resistance study. Regional association fine mapping was carried out using additional single‐nucleotide polymorphisms.
Results
The estimated heritability of circulating VAP‐1 levels is high (h2 = 69%). The most significant quantitative trait locus for circulating VAP‐1 was located at 38 cM on chromosome 20, with a maximum empirical logarithm of odds score of 4.11 (P = 6.86 × 10−6) in females. Regional single‐nucleotide polymorphism fine mapping within a 1‐unit support region showed the strongest association signals in the MACRO domain containing 2 (MACROD2) gene in females (P = 5.38 × 10−6). Knockdown of MACROD2 significantly suppressed VAP‐1 expression in human adipocytes, as well as the expression of key adipogenic genes. Furthermore, MACROD2 expression was found to be positively associated with VAP‐1 in human visceral adipose tissue.
Conclusion
MACROD2 is a potential genetic determinant of serum VAP‐1 levels, probably through transcriptional regulation of adipogenesis.
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound aminine oxidase that is highly expressed in mature adipocyte and is released into circulating. VAP‐1 has been strongly implicated in several pathological processes and is an important disease marker as well as therapeutic target for pharmaceutical industry. We conducted the first genome‐wide scan for circulating VAP‐1 levels in a large family cohort. We identified MACROD2 is a qualitative trait loci for circulating VAP‐1.</description><identifier>ISSN: 2040-1116</identifier><identifier>EISSN: 2040-1124</identifier><identifier>DOI: 10.1111/jdi.12805</identifier><identifier>PMID: 29364582</identifier><language>eng</language><publisher>Japan: John Wiley and Sons Inc</publisher><subject>Adipogenesis - genetics ; Amine Oxidase (Copper-Containing) - genetics ; Biomarkers - metabolism ; Cell Adhesion Molecules - genetics ; DNA Repair Enzymes - genetics ; Female ; Follow-Up Studies ; Gene Expression Regulation ; Genetic Linkage ; Humans ; Hydrolases - genetics ; Insulin Resistance ; Linkage analysis ; MACRO domain containing 2 gene ; Male ; Original ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Taiwan ; Vascular adhesion protein‐1</subject><ispartof>Journal of diabetes investigation, 2018-09, Vol.9 (5), p.1067-1074</ispartof><rights>2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd</rights><rights>2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2665-3635 ; 0000-0003-0978-2662 ; 0000-0002-8077-5011 ; 0000-0002-3352-4500</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123039/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123039/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29364582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Yi‐Cheng</creatorcontrib><creatorcontrib>Hee, Siow‐Wey</creatorcontrib><creatorcontrib>Lee, Wei‐Jei</creatorcontrib><creatorcontrib>Li, Hung‐Yuan</creatorcontrib><creatorcontrib>Chang, Tien‐Jyun</creatorcontrib><creatorcontrib>Lin, Ming‐Wei</creatorcontrib><creatorcontrib>Hung, Yi‐Jen</creatorcontrib><creatorcontrib>Lee, I‐Te</creatorcontrib><creatorcontrib>Hung, Kuan‐Yi</creatorcontrib><creatorcontrib>Assimes, Themistocles</creatorcontrib><creatorcontrib>Knowles, Joshua W</creatorcontrib><creatorcontrib>Nong, Jiun‐Yi</creatorcontrib><creatorcontrib>Lee, Po‐Chu</creatorcontrib><creatorcontrib>Chiu, Yen‐Feng</creatorcontrib><creatorcontrib>Chuang, Lee‐Ming</creatorcontrib><title>Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis</title><title>Journal of diabetes investigation</title><addtitle>J Diabetes Investig</addtitle><description>Aims/Introduction
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound amine oxidase highly expressed in mature adipocytes and released into the circulation. VAP‐1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. Here, we aimed to identify the genetic loci for circulating VAP‐1 levels.
Materials and Methods
We carried out a genomic‐wide linkage scan for the quantitative trait locus of circulating VAP‐1 levels in 1,100 Han Chinese individuals from 398 families in the Stanford Asian Pacific Program for Hypertension and Insulin Resistance study. Regional association fine mapping was carried out using additional single‐nucleotide polymorphisms.
Results
The estimated heritability of circulating VAP‐1 levels is high (h2 = 69%). The most significant quantitative trait locus for circulating VAP‐1 was located at 38 cM on chromosome 20, with a maximum empirical logarithm of odds score of 4.11 (P = 6.86 × 10−6) in females. Regional single‐nucleotide polymorphism fine mapping within a 1‐unit support region showed the strongest association signals in the MACRO domain containing 2 (MACROD2) gene in females (P = 5.38 × 10−6). Knockdown of MACROD2 significantly suppressed VAP‐1 expression in human adipocytes, as well as the expression of key adipogenic genes. Furthermore, MACROD2 expression was found to be positively associated with VAP‐1 in human visceral adipose tissue.
Conclusion
MACROD2 is a potential genetic determinant of serum VAP‐1 levels, probably through transcriptional regulation of adipogenesis.
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound aminine oxidase that is highly expressed in mature adipocyte and is released into circulating. VAP‐1 has been strongly implicated in several pathological processes and is an important disease marker as well as therapeutic target for pharmaceutical industry. We conducted the first genome‐wide scan for circulating VAP‐1 levels in a large family cohort. We identified MACROD2 is a qualitative trait loci for circulating VAP‐1.</description><subject>Adipogenesis - genetics</subject><subject>Amine Oxidase (Copper-Containing) - genetics</subject><subject>Biomarkers - metabolism</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>DNA Repair Enzymes - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Expression Regulation</subject><subject>Genetic Linkage</subject><subject>Humans</subject><subject>Hydrolases - genetics</subject><subject>Insulin Resistance</subject><subject>Linkage analysis</subject><subject>MACRO domain containing 2 gene</subject><subject>Male</subject><subject>Original</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quantitative Trait Loci</subject><subject>Taiwan</subject><subject>Vascular adhesion protein‐1</subject><issn>2040-1116</issn><issn>2040-1124</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNpVUctuFDEQtBCIREsO_ADykcsmfoznwQEp2jwICoqEkrPV9vROHHntwZ7dKLdcufGNfAneJKygLy6rqqvabkLec3bISx3d9e6Qi5apV2RfsIrNORfV6x3m9R45yPmOlZJtW9fNW7InOllXqhX75Oc5hrjC34-_7l2PNFsIdBkTtS7ZtYfJhYFuIG9xotDfYnYx0DHFCV0oXZx63KDPn-i348X3qxNBIVOgY-HD5MDTKUHINrlxKo3lnnDY-paIuCyGbowDhuKa35E3S_AZD17OGbk5O71efJlfXp1fLI4v54PspJqXl9amB6kaZdrOIjMNNpYbbgzWS-DArZGVUqzvoa2w4j0agYbVrWisNVzOyOdn33FtVtjbMmcCr8fkVpAedASn_2eCu9VD3OiaC8nKDDPy8cUgxR9rzJNeuWzRewgY11nzrmOtUpKrIv3wb9Yu5O__F8HRs-DeeXzY8Zzp7W512a1-2q3-enLxBOQfmimcDg</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Chang, Yi‐Cheng</creator><creator>Hee, Siow‐Wey</creator><creator>Lee, Wei‐Jei</creator><creator>Li, Hung‐Yuan</creator><creator>Chang, Tien‐Jyun</creator><creator>Lin, Ming‐Wei</creator><creator>Hung, Yi‐Jen</creator><creator>Lee, I‐Te</creator><creator>Hung, Kuan‐Yi</creator><creator>Assimes, Themistocles</creator><creator>Knowles, Joshua W</creator><creator>Nong, Jiun‐Yi</creator><creator>Lee, Po‐Chu</creator><creator>Chiu, Yen‐Feng</creator><creator>Chuang, Lee‐Ming</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2665-3635</orcidid><orcidid>https://orcid.org/0000-0003-0978-2662</orcidid><orcidid>https://orcid.org/0000-0002-8077-5011</orcidid><orcidid>https://orcid.org/0000-0002-3352-4500</orcidid></search><sort><creationdate>201809</creationdate><title>Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis</title><author>Chang, Yi‐Cheng ; Hee, Siow‐Wey ; Lee, Wei‐Jei ; Li, Hung‐Yuan ; Chang, Tien‐Jyun ; Lin, Ming‐Wei ; Hung, Yi‐Jen ; Lee, I‐Te ; Hung, Kuan‐Yi ; Assimes, Themistocles ; Knowles, Joshua W ; Nong, Jiun‐Yi ; Lee, Po‐Chu ; Chiu, Yen‐Feng ; Chuang, Lee‐Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g3935-2806bda3575b89ce0b7e7c1b1bbe6fa1a1cb34550dda84e41deb2eb06827ccb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipogenesis - genetics</topic><topic>Amine Oxidase (Copper-Containing) - genetics</topic><topic>Biomarkers - metabolism</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>DNA Repair Enzymes - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Expression Regulation</topic><topic>Genetic Linkage</topic><topic>Humans</topic><topic>Hydrolases - genetics</topic><topic>Insulin Resistance</topic><topic>Linkage analysis</topic><topic>MACRO domain containing 2 gene</topic><topic>Male</topic><topic>Original</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quantitative Trait Loci</topic><topic>Taiwan</topic><topic>Vascular adhesion protein‐1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Yi‐Cheng</creatorcontrib><creatorcontrib>Hee, Siow‐Wey</creatorcontrib><creatorcontrib>Lee, Wei‐Jei</creatorcontrib><creatorcontrib>Li, Hung‐Yuan</creatorcontrib><creatorcontrib>Chang, Tien‐Jyun</creatorcontrib><creatorcontrib>Lin, Ming‐Wei</creatorcontrib><creatorcontrib>Hung, Yi‐Jen</creatorcontrib><creatorcontrib>Lee, I‐Te</creatorcontrib><creatorcontrib>Hung, Kuan‐Yi</creatorcontrib><creatorcontrib>Assimes, Themistocles</creatorcontrib><creatorcontrib>Knowles, Joshua W</creatorcontrib><creatorcontrib>Nong, Jiun‐Yi</creatorcontrib><creatorcontrib>Lee, Po‐Chu</creatorcontrib><creatorcontrib>Chiu, Yen‐Feng</creatorcontrib><creatorcontrib>Chuang, Lee‐Ming</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Yi‐Cheng</au><au>Hee, Siow‐Wey</au><au>Lee, Wei‐Jei</au><au>Li, Hung‐Yuan</au><au>Chang, Tien‐Jyun</au><au>Lin, Ming‐Wei</au><au>Hung, Yi‐Jen</au><au>Lee, I‐Te</au><au>Hung, Kuan‐Yi</au><au>Assimes, Themistocles</au><au>Knowles, Joshua W</au><au>Nong, Jiun‐Yi</au><au>Lee, Po‐Chu</au><au>Chiu, Yen‐Feng</au><au>Chuang, Lee‐Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis</atitle><jtitle>Journal of diabetes investigation</jtitle><addtitle>J Diabetes Investig</addtitle><date>2018-09</date><risdate>2018</risdate><volume>9</volume><issue>5</issue><spage>1067</spage><epage>1074</epage><pages>1067-1074</pages><issn>2040-1116</issn><eissn>2040-1124</eissn><abstract>Aims/Introduction
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound amine oxidase highly expressed in mature adipocytes and released into the circulation. VAP‐1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. Here, we aimed to identify the genetic loci for circulating VAP‐1 levels.
Materials and Methods
We carried out a genomic‐wide linkage scan for the quantitative trait locus of circulating VAP‐1 levels in 1,100 Han Chinese individuals from 398 families in the Stanford Asian Pacific Program for Hypertension and Insulin Resistance study. Regional association fine mapping was carried out using additional single‐nucleotide polymorphisms.
Results
The estimated heritability of circulating VAP‐1 levels is high (h2 = 69%). The most significant quantitative trait locus for circulating VAP‐1 was located at 38 cM on chromosome 20, with a maximum empirical logarithm of odds score of 4.11 (P = 6.86 × 10−6) in females. Regional single‐nucleotide polymorphism fine mapping within a 1‐unit support region showed the strongest association signals in the MACRO domain containing 2 (MACROD2) gene in females (P = 5.38 × 10−6). Knockdown of MACROD2 significantly suppressed VAP‐1 expression in human adipocytes, as well as the expression of key adipogenic genes. Furthermore, MACROD2 expression was found to be positively associated with VAP‐1 in human visceral adipose tissue.
Conclusion
MACROD2 is a potential genetic determinant of serum VAP‐1 levels, probably through transcriptional regulation of adipogenesis.
Vascular adhesion protein‐1 (VAP‐1) is a membrane‐bound aminine oxidase that is highly expressed in mature adipocyte and is released into circulating. VAP‐1 has been strongly implicated in several pathological processes and is an important disease marker as well as therapeutic target for pharmaceutical industry. We conducted the first genome‐wide scan for circulating VAP‐1 levels in a large family cohort. We identified MACROD2 is a qualitative trait loci for circulating VAP‐1.</abstract><cop>Japan</cop><pub>John Wiley and Sons Inc</pub><pmid>29364582</pmid><doi>10.1111/jdi.12805</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2665-3635</orcidid><orcidid>https://orcid.org/0000-0003-0978-2662</orcidid><orcidid>https://orcid.org/0000-0002-8077-5011</orcidid><orcidid>https://orcid.org/0000-0002-3352-4500</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipogenesis - genetics Amine Oxidase (Copper-Containing) - genetics Biomarkers - metabolism Cell Adhesion Molecules - genetics DNA Repair Enzymes - genetics Female Follow-Up Studies Gene Expression Regulation Genetic Linkage Humans Hydrolases - genetics Insulin Resistance Linkage analysis MACRO domain containing 2 gene Male Original Polymorphism, Single Nucleotide Quantitative Trait Loci Taiwan Vascular adhesion protein‐1 |
| title | Genome‐wide scan for circulating vascular adhesion protein‐1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis |
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