Combined antitumor effects of P-5m octapeptide and 5-fluorouracil on a murine model of H22 hepatoma ascites
The present study has demonstrated that P-5m octapeptide (P-5m) has therapeutic potential in metastatic human hepatocarcinoma, possibly through the modulation of matrix metalloproteinase-2 expression. The purpose of the present study was to evaluate the antitumor effect of P-5m combined with 5-fluor...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2018-09, Vol.16 (3), p.1586-1592 |
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| creator | Han, Xiao An, Liping Yan, Dongmei Hiroshi, Matsuura Ding, Weiguang Zhang, Mengchuan Xu, Guangyu Sun, Ying Yuan, Guangxin Wang, Manli Zhao, Nanxi Sun, Jingbo Zhu, Xun Du, Peige |
| description | The present study has demonstrated that P-5m octapeptide (P-5m) has therapeutic potential in metastatic human hepatocarcinoma, possibly through the modulation of matrix metalloproteinase-2 expression. The purpose of the present study was to evaluate the antitumor effect of P-5m combined with 5-fluorouracil (5-Fu) on the treatment of hepatoma 22 (H22) hepatocarcinoma malignant ascites in a mouse model. The inhibitory effect on the growth of mouse ascites tumors was monitored by measuring body weight gain, survival time, ascites volume, numbers of tumor cells, DNA synthesis and peritoneal capillary permeability analysis. The present data revealed a significant reduction in ascites volume and cell count in mice that were treated with P-5m plus 5-Fu. Furthermore, the median survival time in mice in the combination group was prolonged compared with the disease control group. Moreover, a significant reduction in the total H22 ascites cell count in mice from the combination group was observed when compared with the disease control group. P-5m plus 5-Fu was able to induce the cell cycle arrest and inhibit the peritoneal capillary permeability of the mice. To conclude, the present study indicated that P-5m may have therapeutic potential in ascites caused by hepatocellular carcinoma. |
| doi_str_mv | 10.3892/etm.2018.6422 |
| format | Article |
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The purpose of the present study was to evaluate the antitumor effect of P-5m combined with 5-fluorouracil (5-Fu) on the treatment of hepatoma 22 (H22) hepatocarcinoma malignant ascites in a mouse model. The inhibitory effect on the growth of mouse ascites tumors was monitored by measuring body weight gain, survival time, ascites volume, numbers of tumor cells, DNA synthesis and peritoneal capillary permeability analysis. The present data revealed a significant reduction in ascites volume and cell count in mice that were treated with P-5m plus 5-Fu. Furthermore, the median survival time in mice in the combination group was prolonged compared with the disease control group. Moreover, a significant reduction in the total H22 ascites cell count in mice from the combination group was observed when compared with the disease control group. P-5m plus 5-Fu was able to induce the cell cycle arrest and inhibit the peritoneal capillary permeability of the mice. To conclude, the present study indicated that P-5m may have therapeutic potential in ascites caused by hepatocellular carcinoma.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.6422</identifier><identifier>PMID: 30186375</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Cancer therapies ; Care and treatment ; Cell cycle ; Chemotherapy ; Dosage and administration ; Drug dosages ; Fluorouracil ; Genetic aspects ; Hepatocellular carcinoma ; Laboratory animals ; Liver cancer ; Medical prognosis ; Melanoma ; Metastasis ; Ovarian cancer ; Peptides ; Standard deviation ; Transplants & implants ; Tumors</subject><ispartof>Experimental and therapeutic medicine, 2018-09, Vol.16 (3), p.1586-1592</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Han et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c438t-1e20b850d715937ff296173397f2a7f40d379754766cb78d522a007a0db042393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122418/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122418/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30186375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Xiao</creatorcontrib><creatorcontrib>An, Liping</creatorcontrib><creatorcontrib>Yan, Dongmei</creatorcontrib><creatorcontrib>Hiroshi, Matsuura</creatorcontrib><creatorcontrib>Ding, Weiguang</creatorcontrib><creatorcontrib>Zhang, Mengchuan</creatorcontrib><creatorcontrib>Xu, Guangyu</creatorcontrib><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Yuan, Guangxin</creatorcontrib><creatorcontrib>Wang, Manli</creatorcontrib><creatorcontrib>Zhao, Nanxi</creatorcontrib><creatorcontrib>Sun, Jingbo</creatorcontrib><creatorcontrib>Zhu, Xun</creatorcontrib><creatorcontrib>Du, Peige</creatorcontrib><title>Combined antitumor effects of P-5m octapeptide and 5-fluorouracil on a murine model of H22 hepatoma ascites</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The present study has demonstrated that P-5m octapeptide (P-5m) has therapeutic potential in metastatic human hepatocarcinoma, possibly through the modulation of matrix metalloproteinase-2 expression. The purpose of the present study was to evaluate the antitumor effect of P-5m combined with 5-fluorouracil (5-Fu) on the treatment of hepatoma 22 (H22) hepatocarcinoma malignant ascites in a mouse model. The inhibitory effect on the growth of mouse ascites tumors was monitored by measuring body weight gain, survival time, ascites volume, numbers of tumor cells, DNA synthesis and peritoneal capillary permeability analysis. The present data revealed a significant reduction in ascites volume and cell count in mice that were treated with P-5m plus 5-Fu. Furthermore, the median survival time in mice in the combination group was prolonged compared with the disease control group. Moreover, a significant reduction in the total H22 ascites cell count in mice from the combination group was observed when compared with the disease control group. P-5m plus 5-Fu was able to induce the cell cycle arrest and inhibit the peritoneal capillary permeability of the mice. To conclude, the present study indicated that P-5m may have therapeutic potential in ascites caused by hepatocellular carcinoma.</description><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Dosage and administration</subject><subject>Drug dosages</subject><subject>Fluorouracil</subject><subject>Genetic aspects</subject><subject>Hepatocellular carcinoma</subject><subject>Laboratory animals</subject><subject>Liver cancer</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Ovarian cancer</subject><subject>Peptides</subject><subject>Standard deviation</subject><subject>Transplants & implants</subject><subject>Tumors</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1rFTEYhYMotly7dCsBN27mmo_JJNkI5aKtUNCFrkMmH23qZDImmYL_3gy9rVZMIAnJc054Xw4ArzHaUyHJe1fjniAs9kNPyDNwirkkHUaYPT-ekRT4BJyVcovaYAMWgr0EJ7RpBsrZKfhxSHEMs7NQzzXUNaYMnffO1AKTh187FmEyVS9uqcG6RlnIOj-tKac1axMmmGaoYVxzc4ExWTdtwktC4I1bdE1RQ11MqK68Ai-8noo7O-478P3Tx2-Hy-7qy8Xnw_lVZ3oqaocdQaNgyHLMJOXeEzlgTqnknmjue2Qpl5z1fBjMyIVlhGiEuEZ2RD2hku7Ah3vfZR2js8bNNetJLTlEnX-ppIN6-jKHG3Wd7tSACemxaAbvjgY5_VxdqSqGYtw06dmltSiCEaKU0LbuwNt_0NvWl7mVpwiSkmIkqPhDXevJqTD71P41m6k6Z60SMQjCGrX_D9WmdTGYNDsf2v0TQXcvMDmVkp1_rBEjtQVEtYCoLSBqC0jj3_zdmEf6IQ70N4nUs2Y</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Han, Xiao</creator><creator>An, Liping</creator><creator>Yan, Dongmei</creator><creator>Hiroshi, Matsuura</creator><creator>Ding, Weiguang</creator><creator>Zhang, Mengchuan</creator><creator>Xu, Guangyu</creator><creator>Sun, Ying</creator><creator>Yuan, Guangxin</creator><creator>Wang, Manli</creator><creator>Zhao, Nanxi</creator><creator>Sun, Jingbo</creator><creator>Zhu, Xun</creator><creator>Du, Peige</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Combined antitumor effects of P-5m octapeptide and 5-fluorouracil on a murine model of H22 hepatoma ascites</title><author>Han, Xiao ; An, Liping ; Yan, Dongmei ; Hiroshi, Matsuura ; Ding, Weiguang ; Zhang, Mengchuan ; Xu, Guangyu ; Sun, Ying ; Yuan, Guangxin ; Wang, Manli ; Zhao, Nanxi ; Sun, Jingbo ; Zhu, Xun ; Du, Peige</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-1e20b850d715937ff296173397f2a7f40d379754766cb78d522a007a0db042393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cell cycle</topic><topic>Chemotherapy</topic><topic>Dosage and administration</topic><topic>Drug dosages</topic><topic>Fluorouracil</topic><topic>Genetic aspects</topic><topic>Hepatocellular carcinoma</topic><topic>Laboratory animals</topic><topic>Liver cancer</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Metastasis</topic><topic>Ovarian cancer</topic><topic>Peptides</topic><topic>Standard deviation</topic><topic>Transplants & implants</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Han, Xiao</creatorcontrib><creatorcontrib>An, Liping</creatorcontrib><creatorcontrib>Yan, Dongmei</creatorcontrib><creatorcontrib>Hiroshi, Matsuura</creatorcontrib><creatorcontrib>Ding, Weiguang</creatorcontrib><creatorcontrib>Zhang, Mengchuan</creatorcontrib><creatorcontrib>Xu, Guangyu</creatorcontrib><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Yuan, Guangxin</creatorcontrib><creatorcontrib>Wang, Manli</creatorcontrib><creatorcontrib>Zhao, Nanxi</creatorcontrib><creatorcontrib>Sun, Jingbo</creatorcontrib><creatorcontrib>Zhu, Xun</creatorcontrib><creatorcontrib>Du, Peige</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Xiao</au><au>An, Liping</au><au>Yan, Dongmei</au><au>Hiroshi, Matsuura</au><au>Ding, Weiguang</au><au>Zhang, Mengchuan</au><au>Xu, Guangyu</au><au>Sun, Ying</au><au>Yuan, Guangxin</au><au>Wang, Manli</au><au>Zhao, Nanxi</au><au>Sun, Jingbo</au><au>Zhu, Xun</au><au>Du, Peige</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined antitumor effects of P-5m octapeptide and 5-fluorouracil on a murine model of H22 hepatoma ascites</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>16</volume><issue>3</issue><spage>1586</spage><epage>1592</epage><pages>1586-1592</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>The present study has demonstrated that P-5m octapeptide (P-5m) has therapeutic potential in metastatic human hepatocarcinoma, possibly through the modulation of matrix metalloproteinase-2 expression. The purpose of the present study was to evaluate the antitumor effect of P-5m combined with 5-fluorouracil (5-Fu) on the treatment of hepatoma 22 (H22) hepatocarcinoma malignant ascites in a mouse model. The inhibitory effect on the growth of mouse ascites tumors was monitored by measuring body weight gain, survival time, ascites volume, numbers of tumor cells, DNA synthesis and peritoneal capillary permeability analysis. The present data revealed a significant reduction in ascites volume and cell count in mice that were treated with P-5m plus 5-Fu. Furthermore, the median survival time in mice in the combination group was prolonged compared with the disease control group. Moreover, a significant reduction in the total H22 ascites cell count in mice from the combination group was observed when compared with the disease control group. P-5m plus 5-Fu was able to induce the cell cycle arrest and inhibit the peritoneal capillary permeability of the mice. To conclude, the present study indicated that P-5m may have therapeutic potential in ascites caused by hepatocellular carcinoma.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30186375</pmid><doi>10.3892/etm.2018.6422</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer therapies Care and treatment Cell cycle Chemotherapy Dosage and administration Drug dosages Fluorouracil Genetic aspects Hepatocellular carcinoma Laboratory animals Liver cancer Medical prognosis Melanoma Metastasis Ovarian cancer Peptides Standard deviation Transplants & implants Tumors |
| title | Combined antitumor effects of P-5m octapeptide and 5-fluorouracil on a murine model of H22 hepatoma ascites |
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