Combination ART-Induced Oxidative/Nitrosative Stress, Neurogenic Inflammation and Cardiac Dysfunction in HIV-1 Transgenic (Tg) Rats: Protection by Mg

Chronic effects of a combination antiretroviral therapy (cART = tenofovir/emtricitatine + atazanavir/ritonavir) on systemic and cardiac oxidative stress/injury in HIV-1 transgenic (Tg) rats and protection by Mg-supplementation were assessed. cART (low doses) elicited no significant effects in normal...

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Veröffentlicht in:	International journal of molecular sciences 2018-08, Vol.19 (8), p.2409
Hauptverfasser:	Mak, I Tong, Chmielinska, Joanna J, Spurney, Christopher F, Weglicki, William B, Kramer, Jay H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Retroviral Agents - adverse effects Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - adverse effects Calcium Cardiotoxins - adverse effects Chronic effects Creatinine Gene Expression Heart - drug effects Heart - physiopathology HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - genetics Hypomagnesemia Kidney - drug effects Kidney - physiopathology Magnesium - therapeutic use Male Muscle contraction Neurogenic Inflammation - chemically induced Neurogenic Inflammation - physiopathology Neurogenic Inflammation - prevention & control Neutrophil Activation - drug effects Nitrosative Stress - drug effects Nitrotyrosine Oxidative stress Oxidative Stress - drug effects Protective Agents - therapeutic use Rats Rats, Inbred F344 Rats, Transgenic Ritonavir Rodents Staining Substance P Superoxide Tenofovir Urea
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