Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis

Background & Aims Antibiotic (ABx) therapy is associated with increased risk for Crohn’s disease but underlying mechanisms are unknown. We observed high fecal serine protease activity (PA) to be a frequent side effect of ABx therapy. The aim of the present study was to unravel whether this rise...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2018-01, Vol.6 (3), p.370-388.e3
Hauptverfasser:	Yoon, Hongsup, Schaubeck, Monika, Lagkouvardos, Ilias, Blesl, Andreas, Heinzlmeir, Stephanie, Hahne, Hannes, Clavel, Thomas, Panda, Suchita, Ludwig, Christina, Kuster, Bernhard, Manichanh, Chaysavanh, Kump, Patrizia, Haller, Dirk, Hörmannsperger, Gabriele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - adverse effects Colitis - chemically induced Colitis - metabolism Dextran Sulfate - pharmacology Disease Models, Animal Epithelial Barrier Feces - enzymology Feces - microbiology Gastroenterology and Hepatology Gut Microbiota Humans Inflammatory Bowel Diseases Intestine, Large - enzymology Intestine, Large - microbiology Metronidazole - adverse effects Mice Mice, Inbred C57BL Mice, Knockout Original Research Risk Factors Serine Proteases Serine Proteases - metabolism Sulfones - pharmacology Vancomycin - adverse effects
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