Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models have proposed that DNA binding motifs and sites of chromatin accessibility predetermine GR binding and activity. How...

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Veröffentlicht in:	Genome research 2018-09, Vol.28 (9), p.1272-1284
Hauptverfasser:	McDowell, Ian C, Barrera, Alejandro, D'Ippolito, Anthony M, Vockley, Christopher M, Hong, Linda K, Leichter, Sarah M, Bartelt, Luke C, Majoros, William H, Song, Lingyun, Safi, Alexias, Koçak, D Dewran, Gersbach, Charles A, Hartemink, Alexander J, Crawford, Gregory E, Engelhardt, Barbara E, Reddy, Timothy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Cell Line, Tumor Chromatin Enhancer Elements, Genetic Enhancers Epigenesis, Genetic Epigenetics Gene expression Genomes Glucocorticoids Histone Code Humans Nucleotide Motifs Protein Binding Receptors, Glucocorticoid - metabolism Steroid hormones Transcription Factors - metabolism Transcriptional Activation
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