Effects of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory diseases and periodontitis is known to be more common and more severe in patients with RA. Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csD...
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| description | Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory diseases and periodontitis is known to be more common and more severe in patients with RA. Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and periodontitis, this prospective study aimed to evaluate the adjunctive effect of csDMARDs on response to nonsurgical periodontal treatment in patients with RA. Thirty-two patients with RA (RA group) and 32 systemically healthy patients (control group) with periodontitis were included in this study. The RA group patients were treated with csDMARDs, such as methotrexate, hydroxychloroquine, and sulfasalazine. Conventional nonsurgical periodontal treatment with scaling and root planing was performed in both groups. The extent and severity of periodontitis were evaluated by plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at baseline and 4 weeks after periodontal treatment. There was no statistically significant difference of periodontal parameters between the RA and control groups at baseline. Four weeks after scaling and root planing, PD reduction, and CAL gain were higher in the RA group treated with csDMARDs compared to the control group, and the difference was statistically significant (P = 0.006 and 0.003, respectively). A post hoc analysis of the RA group showed no statistically significant difference on the response to nonsurgical periodontal treatment in multiple csDMARDs therapy and addition of NSAIDs and/or steroids to csDMARDs. In patients with RA, csDMARDs showed beneficial effect on periodontal clinical parameters following the nonsurgical periodontal treatment. |
| doi_str_mv | 10.1155/2018/1465402 |
| format | Article |
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Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and periodontitis, this prospective study aimed to evaluate the adjunctive effect of csDMARDs on response to nonsurgical periodontal treatment in patients with RA. Thirty-two patients with RA (RA group) and 32 systemically healthy patients (control group) with periodontitis were included in this study. The RA group patients were treated with csDMARDs, such as methotrexate, hydroxychloroquine, and sulfasalazine. Conventional nonsurgical periodontal treatment with scaling and root planing was performed in both groups. The extent and severity of periodontitis were evaluated by plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at baseline and 4 weeks after periodontal treatment. There was no statistically significant difference of periodontal parameters between the RA and control groups at baseline. Four weeks after scaling and root planing, PD reduction, and CAL gain were higher in the RA group treated with csDMARDs compared to the control group, and the difference was statistically significant (P = 0.006 and 0.003, respectively). A post hoc analysis of the RA group showed no statistically significant difference on the response to nonsurgical periodontal treatment in multiple csDMARDs therapy and addition of NSAIDs and/or steroids to csDMARDs. In patients with RA, csDMARDs showed beneficial effect on periodontal clinical parameters following the nonsurgical periodontal treatment.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/1465402</identifier><identifier>PMID: 30211216</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adalimumab ; Adult ; Aged ; Analysis ; Antirheumatic Agents - therapeutic use ; Arthritis ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - drug therapy ; Biomarkers ; Bleeding ; Care and treatment ; Chronic Periodontitis - complications ; Chronic Periodontitis - therapy ; Clinical Study ; Cytokines ; Dental Plaque Index ; Dentistry ; Drugs ; Female ; Follow-Up Studies ; Gingival index ; Health risk assessment ; Humans ; Hydroxychloroquine ; Inflammatory diseases ; Kinases ; Male ; Medical research ; Medicine, Experimental ; Methotrexate ; Middle Aged ; Nonsteroidal anti-inflammatory drugs ; Parameters ; Patients ; Periodontal Attachment Loss ; Periodontitis ; Planing ; Plaque index ; Prospective Studies ; Rheumatoid arthritis ; Rheumatoid factor ; Root Planing ; Scaling ; Statistical analysis ; Statistical significance ; Steroid hormones ; Steroids ; Sulfasalazine ; Teeth ; Tumor necrosis factor-TNF</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-7</ispartof><rights>Copyright © 2018 Gyu-Un Jung et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Gyu-Un Jung et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Gyu-Un Jung et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-f916130846c0f4ba13fdce599d76deec38ea617890ca52cc03da2bef0433d9043</citedby><cites>FETCH-LOGICAL-c499t-f916130846c0f4ba13fdce599d76deec38ea617890ca52cc03da2bef0433d9043</cites><orcidid>0000-0002-6895-9854</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120284/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120284/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30211216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nozawa, Kazuhisa</contributor><contributor>Kazuhisa Nozawa</contributor><creatorcontrib>Stathopoulou, Panagiota G.</creatorcontrib><creatorcontrib>Park, Chang-Joo</creatorcontrib><creatorcontrib>Hwang, Kyung-Gyun</creatorcontrib><creatorcontrib>Han, Ji-Young</creatorcontrib><creatorcontrib>Jung, Gyu-Un</creatorcontrib><creatorcontrib>Fiorellini, Joseph P.</creatorcontrib><title>Effects of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory diseases and periodontitis is known to be more common and more severe in patients with RA. Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and periodontitis, this prospective study aimed to evaluate the adjunctive effect of csDMARDs on response to nonsurgical periodontal treatment in patients with RA. Thirty-two patients with RA (RA group) and 32 systemically healthy patients (control group) with periodontitis were included in this study. The RA group patients were treated with csDMARDs, such as methotrexate, hydroxychloroquine, and sulfasalazine. Conventional nonsurgical periodontal treatment with scaling and root planing was performed in both groups. The extent and severity of periodontitis were evaluated by plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at baseline and 4 weeks after periodontal treatment. There was no statistically significant difference of periodontal parameters between the RA and control groups at baseline. Four weeks after scaling and root planing, PD reduction, and CAL gain were higher in the RA group treated with csDMARDs compared to the control group, and the difference was statistically significant (P = 0.006 and 0.003, respectively). A post hoc analysis of the RA group showed no statistically significant difference on the response to nonsurgical periodontal treatment in multiple csDMARDs therapy and addition of NSAIDs and/or steroids to csDMARDs. In patients with RA, csDMARDs showed beneficial effect on periodontal clinical parameters following the nonsurgical periodontal treatment.</description><subject>Adalimumab</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Biomarkers</subject><subject>Bleeding</subject><subject>Care and treatment</subject><subject>Chronic Periodontitis - complications</subject><subject>Chronic Periodontitis - therapy</subject><subject>Clinical Study</subject><subject>Cytokines</subject><subject>Dental Plaque Index</subject><subject>Dentistry</subject><subject>Drugs</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gingival index</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hydroxychloroquine</subject><subject>Inflammatory diseases</subject><subject>Kinases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Methotrexate</subject><subject>Middle Aged</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Parameters</subject><subject>Patients</subject><subject>Periodontal Attachment Loss</subject><subject>Periodontitis</subject><subject>Planing</subject><subject>Plaque index</subject><subject>Prospective Studies</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Root Planing</subject><subject>Scaling</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Sulfasalazine</subject><subject>Teeth</subject><subject>Tumor necrosis 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of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis</title><author>Stathopoulou, Panagiota G. ; Park, Chang-Joo ; Hwang, Kyung-Gyun ; Han, Ji-Young ; Jung, Gyu-Un ; Fiorellini, Joseph P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-f916130846c0f4ba13fdce599d76deec38ea617890ca52cc03da2bef0433d9043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adalimumab</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Biomarkers</topic><topic>Bleeding</topic><topic>Care and treatment</topic><topic>Chronic Periodontitis - complications</topic><topic>Chronic Periodontitis - therapy</topic><topic>Clinical Study</topic><topic>Cytokines</topic><topic>Dental Plaque Index</topic><topic>Dentistry</topic><topic>Drugs</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gingival index</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hydroxychloroquine</topic><topic>Inflammatory diseases</topic><topic>Kinases</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Methotrexate</topic><topic>Middle Aged</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Parameters</topic><topic>Patients</topic><topic>Periodontal Attachment Loss</topic><topic>Periodontitis</topic><topic>Planing</topic><topic>Plaque index</topic><topic>Prospective Studies</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Root Planing</topic><topic>Scaling</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Steroid 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Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory diseases and periodontitis is known to be more common and more severe in patients with RA. Based on a paucity of studies about the relationship between common conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and periodontitis, this prospective study aimed to evaluate the adjunctive effect of csDMARDs on response to nonsurgical periodontal treatment in patients with RA. Thirty-two patients with RA (RA group) and 32 systemically healthy patients (control group) with periodontitis were included in this study. The RA group patients were treated with csDMARDs, such as methotrexate, hydroxychloroquine, and sulfasalazine. Conventional nonsurgical periodontal treatment with scaling and root planing was performed in both groups. The extent and severity of periodontitis were evaluated by plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at baseline and 4 weeks after periodontal treatment. There was no statistically significant difference of periodontal parameters between the RA and control groups at baseline. Four weeks after scaling and root planing, PD reduction, and CAL gain were higher in the RA group treated with csDMARDs compared to the control group, and the difference was statistically significant (P = 0.006 and 0.003, respectively). A post hoc analysis of the RA group showed no statistically significant difference on the response to nonsurgical periodontal treatment in multiple csDMARDs therapy and addition of NSAIDs and/or steroids to csDMARDs. In patients with RA, csDMARDs showed beneficial effect on periodontal clinical parameters following the nonsurgical periodontal treatment.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30211216</pmid><doi>10.1155/2018/1465402</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6895-9854</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adalimumab Adult Aged Analysis Antirheumatic Agents - therapeutic use Arthritis Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Biomarkers Bleeding Care and treatment Chronic Periodontitis - complications Chronic Periodontitis - therapy Clinical Study Cytokines Dental Plaque Index Dentistry Drugs Female Follow-Up Studies Gingival index Health risk assessment Humans Hydroxychloroquine Inflammatory diseases Kinases Male Medical research Medicine, Experimental Methotrexate Middle Aged Nonsteroidal anti-inflammatory drugs Parameters Patients Periodontal Attachment Loss Periodontitis Planing Plaque index Prospective Studies Rheumatoid arthritis Rheumatoid factor Root Planing Scaling Statistical analysis Statistical significance Steroid hormones Steroids Sulfasalazine Teeth Tumor necrosis factor-TNF |
| title | Effects of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis |
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