Dietary N‐Glycans from Bovine Lactoferrin and TLR Modulation

Scope Bovine lactoferrin (bLF) is an ingredient of food supplements and infant formulas given its antimicrobial and antiviral properties. We modified bLF enzymatically to alter its N‐glycosylation and to isolate the glycan chains. The aims of this study include (1) to evaluate whether such derivates...

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Veröffentlicht in:	Molecular nutrition & food research 2018-01, Vol.62 (2), p.n/a
Hauptverfasser:	Figueroa‐Lozano, Susana, Valk‐Weeber, Rivca L., Leeuwen, Sander S., Dijkhuizen, Lubbert, Vos, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral activity Biological activity Biotechnology bovine lactoferrin Cattle Cell activation Cell Line Cell lines Chains Dietary supplements Glycan Glycosylation Human behavior Humans Immune system Immunomodulation Infant formulas Lactoferrin Lactoferrin - chemistry Lactoferrin - pharmacology Lymphocytes B Myeloid Differentiation Factor 88 - metabolism N-glycans NF-kappa B - metabolism NF-κB protein NF‐κB N‐glycosylation Pattern recognition Pattern recognition receptors Polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology Proteins Receptors Signal Transduction Signaling TLR2 protein TLR9 protein Toll-Like Receptor 3 - metabolism Toll-Like Receptor 4 - metabolism Toll-Like Receptor 8 - metabolism Toll-like receptors Toll-Like Receptors - metabolism
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