Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway

This study investigated the physiological regulation of brain immune homeostasis in rat primary neuron-glial cultures by sub-nanomolar concentrations of prostaglandin E2 (PGE 2 ). We demonstrated that 0.01 to 10 nM PGE 2 protected dopaminergic neurons against LPS-induced neurotoxicity through a redu...

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