FAN1 protects against repeat expansions in a Fragile X mouse model

•FAN1 protects against repeat expansions in a mouse model of the FXDs.•Protection is seen in somatic tissues, including brain, but is not seen for intergenerational expansions.•As GWAS suggest, FAN1 mutations may affect the age at onset of some Repeat Expansion Diseases. The Fragile X-related disord...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	DNA repair 2018-09, Vol.69, p.1-5
Hauptverfasser:	Zhao, Xiao-Nan, Usdin, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	5′ flap endonuclease activity 5′-3′ exonuclease activity Animals Disease Models, Animal DNA - metabolism DNA Mismatch Repair Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Exodeoxyribonucleases Female FMR1- related disorders (FMR1 disorders) Fragile X syndrome (FXS) Fragile X Syndrome - genetics Fragile X Syndrome - metabolism FX-associated primary ovarian insufficiency (FXPOI) FX-associated tremor and ataxia syndrome (FXTAS) Male Mice Mice, Knockout Mismatch repair Multifunctional Enzymes Mutation Repeat expansion Trinucleotide Repeat Expansion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!