Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis

Red blood cells (RBCs) influence rheology, and release ADP, ATP, and nitric oxide, suggesting a role for RBCs in hemostasis and thrombosis. Here, we provide evidence for a significant contribution of RBCs to thrombus formation. Anemic mice showed enhanced occlusion times upon injury of the carotid a...

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Veröffentlicht in:	The Journal of clinical investigation 2018-09, Vol.128 (9), p.3906-3925
Hauptverfasser:	Klatt, Christoph, Krüger, Irena, Zey, Saskia, Krott, Kim-Jürgen, Spelleken, Martina, Gowert, Nina Sarah, Oberhuber, Alexander, Pfaff, Lena, Lückstädt, Wiebke, Jurk, Kerstin, Schaller, Martin, Al-Hasani, Hadi, Schrader, Jürgen, Massberg, Steffen, Stark, Konstantin, Schelzig, Hubert, Kelm, Malte, Elvers, Margitta
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Apoptosis Biomedical research Blood clots Blood platelets Cancer Carotid artery CD95 antigen Cell activation Clonal deletion Development and progression Erythrocytes FasL protein Health aspects Heart attacks Hemostasis Immune system Ligands Nitric oxide Occlusion Phosphatidylserine Physiological aspects Platelets Red blood cells Rheology Thrombin Thrombosis Tumor necrosis factor
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