The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer
Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs hav...
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| Veröffentlicht in: | Cancers 2018-07, Vol.10 (8), p.251 |
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| creator | Savant, Sudha S Sriramkumar, Shruthi O'Hagan, Heather M |
| description | Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC. |
| doi_str_mv | 10.3390/cancers10080251 |
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There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers10080251</identifier><identifier>PMID: 30061485</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antigens ; Cell division ; Cell proliferation ; Cell survival ; Chemoresistance ; Chemotherapy ; Cytokines ; Epithelial cells ; Fibroblasts ; Gene expression ; Genetic transformation ; Growth factors ; Homeostasis ; Inflammation ; Kinases ; Lymphocytes ; Metastases ; Metastasis ; Oncology ; Ovarian cancer ; Ovulation ; Pathogens ; Peritoneum ; Prostaglandins ; Reactive oxygen species ; Review ; Transcription factors ; Tumor necrosis factor-TNF</subject><ispartof>Cancers, 2018-07, Vol.10 (8), p.251</ispartof><rights>2018. 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| subjects | Antigens Cell division Cell proliferation Cell survival Chemoresistance Chemotherapy Cytokines Epithelial cells Fibroblasts Gene expression Genetic transformation Growth factors Homeostasis Inflammation Kinases Lymphocytes Metastases Metastasis Oncology Ovarian cancer Ovulation Pathogens Peritoneum Prostaglandins Reactive oxygen species Review Transcription factors Tumor necrosis factor-TNF |
| title | The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer |
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