Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure
Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this...
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| Veröffentlicht in: | Journal of the American Society of Nephrology 2018-09, Vol.29 (9), p.2279-2285 |
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| creator | Kamburova, Elena G Wisse, Bram W Joosten, Irma Allebes, Wil A van der Meer, Arnold Hilbrands, Luuk B Baas, Marije C Spierings, Eric Hack, Cornelis E van Reekum, Franka E van Zuilen, Arjan D Verhaar, Marianne C Bots, Michiel L Drop, Adriaan C A D Plaisier, Loes Seelen, Marc A J Sanders, Jan Stephan Hepkema, Bouke G Lambeck, Annechien J A Bungener, Laura B Roozendaal, Caroline Tilanus, Marcel G J Voorter, Christina E Wieten, Lotte van Duijnhoven, Elly M Gelens, Mariëlle A C J Christiaans, Maarten H L van Ittersum, Frans J Nurmohamed, Shaikh A Lardy, Neubury M Swelsen, Wendy van der Pant, Karlijn A M I van der Weerd, Neelke C Ten Berge, Ineke J M Bemelman, Frederike J Hoitsma, Andries J van der Boog, Paul J M de Fijter, Johan W Betjes, Michiel G H Heidt, Sebastiaan Roelen, Dave L Claas, Frans H Otten, Henny G |
| description | Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients.
Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay.
Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non-C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non-C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non-C3d-fixing DSA;
=0.93). Patients without DSA had a 10-year graft survival of 78%.
The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure. |
| doi_str_mv | 10.1681/asn.2018020205 |
| format | Article |
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Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay.
Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non-C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non-C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non-C3d-fixing DSA;
=0.93). Patients without DSA had a 10-year graft survival of 78%.
The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure.</description><identifier>ISSN: 1046-6673</identifier><identifier>EISSN: 1533-3450</identifier><identifier>DOI: 10.1681/asn.2018020205</identifier><identifier>PMID: 30049681</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Rapid Communication</subject><ispartof>Journal of the American Society of Nephrology, 2018-09, Vol.29 (9), p.2279-2285</ispartof><rights>Copyright © 2018 by the American Society of Nephrology.</rights><rights>Copyright © 2018 by the American Society of Nephrology 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-9e25b5e96566427df0cc3179963c6e81c64fff60c4490bc8c60b5478d26ce73d3</citedby><cites>FETCH-LOGICAL-c390t-9e25b5e96566427df0cc3179963c6e81c64fff60c4490bc8c60b5478d26ce73d3</cites><orcidid>0000-0003-0252-5153</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115667/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115667/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30049681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamburova, Elena G</creatorcontrib><creatorcontrib>Wisse, Bram W</creatorcontrib><creatorcontrib>Joosten, Irma</creatorcontrib><creatorcontrib>Allebes, Wil A</creatorcontrib><creatorcontrib>van der Meer, Arnold</creatorcontrib><creatorcontrib>Hilbrands, Luuk B</creatorcontrib><creatorcontrib>Baas, Marije C</creatorcontrib><creatorcontrib>Spierings, Eric</creatorcontrib><creatorcontrib>Hack, Cornelis E</creatorcontrib><creatorcontrib>van Reekum, Franka E</creatorcontrib><creatorcontrib>van Zuilen, Arjan D</creatorcontrib><creatorcontrib>Verhaar, Marianne C</creatorcontrib><creatorcontrib>Bots, Michiel L</creatorcontrib><creatorcontrib>Drop, Adriaan C A D</creatorcontrib><creatorcontrib>Plaisier, Loes</creatorcontrib><creatorcontrib>Seelen, Marc A J</creatorcontrib><creatorcontrib>Sanders, Jan Stephan</creatorcontrib><creatorcontrib>Hepkema, Bouke G</creatorcontrib><creatorcontrib>Lambeck, Annechien J A</creatorcontrib><creatorcontrib>Bungener, Laura B</creatorcontrib><creatorcontrib>Roozendaal, Caroline</creatorcontrib><creatorcontrib>Tilanus, Marcel G J</creatorcontrib><creatorcontrib>Voorter, Christina E</creatorcontrib><creatorcontrib>Wieten, Lotte</creatorcontrib><creatorcontrib>van Duijnhoven, Elly M</creatorcontrib><creatorcontrib>Gelens, Mariëlle A C J</creatorcontrib><creatorcontrib>Christiaans, Maarten H L</creatorcontrib><creatorcontrib>van Ittersum, Frans J</creatorcontrib><creatorcontrib>Nurmohamed, Shaikh A</creatorcontrib><creatorcontrib>Lardy, Neubury M</creatorcontrib><creatorcontrib>Swelsen, Wendy</creatorcontrib><creatorcontrib>van der Pant, Karlijn A M I</creatorcontrib><creatorcontrib>van der Weerd, Neelke C</creatorcontrib><creatorcontrib>Ten Berge, Ineke J M</creatorcontrib><creatorcontrib>Bemelman, Frederike J</creatorcontrib><creatorcontrib>Hoitsma, Andries J</creatorcontrib><creatorcontrib>van der Boog, Paul J M</creatorcontrib><creatorcontrib>de Fijter, Johan W</creatorcontrib><creatorcontrib>Betjes, Michiel G H</creatorcontrib><creatorcontrib>Heidt, Sebastiaan</creatorcontrib><creatorcontrib>Roelen, Dave L</creatorcontrib><creatorcontrib>Claas, Frans H</creatorcontrib><creatorcontrib>Otten, Henny G</creatorcontrib><title>Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure</title><title>Journal of the American Society of Nephrology</title><addtitle>J Am Soc Nephrol</addtitle><description>Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients.
Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay.
Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non-C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non-C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non-C3d-fixing DSA;
=0.93). Patients without DSA had a 10-year graft survival of 78%.
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H</au><au>Heidt, Sebastiaan</au><au>Roelen, Dave L</au><au>Claas, Frans H</au><au>Otten, Henny G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure</atitle><jtitle>Journal of the American Society of Nephrology</jtitle><addtitle>J Am Soc Nephrol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>29</volume><issue>9</issue><spage>2279</spage><epage>2285</epage><pages>2279-2285</pages><issn>1046-6673</issn><eissn>1533-3450</eissn><abstract>Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients.
Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay.
Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non-C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non-C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non-C3d-fixing DSA;
=0.93). Patients without DSA had a 10-year graft survival of 78%.
The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure.</abstract><cop>United States</cop><pub>American Society of Nephrology</pub><pmid>30049681</pmid><doi>10.1681/asn.2018020205</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0252-5153</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-6673 |
| ispartof | Journal of the American Society of Nephrology, 2018-09, Vol.29 (9), p.2279-2285 |
| issn | 1046-6673 1533-3450 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6115667 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Rapid Communication |
| title | Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T05%3A18%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pretransplant%20C3d-Fixing%20Donor-Specific%20Anti-HLA%20Antibodies%20Are%20Not%20Associated%20with%20Increased%20Risk%20for%20Kidney%20Graft%20Failure&rft.jtitle=Journal%20of%20the%20American%20Society%20of%20Nephrology&rft.au=Kamburova,%20Elena%20G&rft.date=2018-09-01&rft.volume=29&rft.issue=9&rft.spage=2279&rft.epage=2285&rft.pages=2279-2285&rft.issn=1046-6673&rft.eissn=1533-3450&rft_id=info:doi/10.1681/asn.2018020205&rft_dat=%3Cproquest_pubme%3E2078580083%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2078580083&rft_id=info:pmid/30049681&rfr_iscdi=true |