Rapid and simple detection of Tamiflu-resistant influenza virus: Development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics

We have developed a novel oseltamivir derivative (oseltamivir hexylthiol; OHT) that exhibits a higher binding affinity for Tamiflu-resistant virus (Tamiflu resistance) than for the wild-type virus (Tamiflu-susceptible virus; WT) as an antibody. First, OHT-modified gold nanoparticles (OHT-GNPs) are u...

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Veröffentlicht in:	Scientific reports 2018-08, Vol.8 (1), p.12999-11, Article 12999
Hauptverfasser:	Hwang, Seul Gee, Ha, Kab, Guk, Kyeonghye, Lee, Do Kyung, Eom, Gayoung, Song, Sinae, Kang, Taejoon, Park, Hwangseo, Jung, Juyeon, Lim, Eun-Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61/350/59 692/700/139 Antiviral drugs Biosensors Colorimetry Disease resistance Drug resistance Exo-a-sialidase Genotype & phenotype Humanities and Social Sciences Influenza multidisciplinary Nanoparticles Oseltamivir Science Science (multidisciplinary) Viruses
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