Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However, detailed mechanisms involved in the treatment of gastric cancer (GC) using kaempferol are not fully understood. In our...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2018-08, Vol.9 (9), p.875-14, Article 875
Hauptverfasser:	Kim, Tae Woo, Lee, Seon Young, Kim, Mia, Cheon, Chunhoo, Ko, Seong-Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/44 13/95 14/1 14/19 45/77 82/1 82/83 96/109 96/2 Antibodies Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Autophagy Autophagy - drug effects Biochemistry Biological activity Biomedical and Life Sciences Cell activation Cell Biology Cell Culture Cell death Cell Line, Tumor Cell survival Cell Survival - drug effects Cellular stress response Cytosol Down-Regulation - drug effects Endoplasmic Reticulum Stress - drug effects Endoribonucleases - metabolism Gastric cancer Histocompatibility Antigens - metabolism Histone deacetylase Histone-Lysine N-Methyltransferase - antagonists & inhibitors Histone-Lysine N-Methyltransferase - metabolism Humans Immunology Kaempferol Kaempferols - pharmacology Kinases Life Sciences MAP Kinase Signaling System - drug effects Phagocytosis Protein Serine-Threonine Kinases - metabolism Signal Transduction - drug effects Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Transcription Factor CHOP - metabolism Tumor cell lines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!