The expression of MMP‐1 and MMP‐9 is up‐regulated by smooth muscle cells after their cross‐talk with macrophages in high glucose conditions

Patients with diabetes mellitus have an increased risk of myocardial infarction and coronary artery disease‐related death, exhibiting highly vulnerable plaques. Many studies have highlighted the major role of macrophages (MAC) and smooth muscle cells (SMC) and the essential part of metalloproteases...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2018-09, Vol.22 (9), p.4366-4376
Hauptverfasser:	Macarie, Razvan Daniel, Vadana, Mihaela, Ciortan, Letitia, Tucureanu, Monica M., Ciobanu, Andrea, Vinereanu, Dragos, Manduteanu, Ileana, Simionescu, Maya, Butoi, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta - cytology Aorta - metabolism Arteriosclerosis Atherosclerosis Cardiovascular disease CCR2 protein cell cross‐talk Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Coculture Techniques Collagen Collagen - genetics Collagen - metabolism Conditioning Coronary artery Coronary artery disease Culture Media, Conditioned - chemistry Diabetes Diabetes mellitus Diffusion Chambers, Culture Enzymatic activity Fetus Gene Expression Regulation Glucose Glucose - metabolism Glucose - pharmacology Health risks Heart diseases high glucose Humans Macrophages Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism matrix metalloproteinases Monocyte chemoattractant protein 1 Monocytes - cytology Monocytes - drug effects Monocytes - metabolism Muscles Myocardial infarction Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism NF-kappa B - genetics NF-kappa B - metabolism Original Plaques Primary Cell Culture Protein kinase C Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Signal Transduction Smooth muscle THP-1 Cells
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