RNF168 facilitates oestrogen receptor ɑ transcription and drives breast cancer proliferation

Oestrogen receptor ɑ (ERɑ) is overexpressed in two‐thirds of all breast cancers and involves in development and breast cancer progression. Although ERɑ‐positive breast cancer could be effective treated by endocrine therapy, the endocrine resistance is still an urgent clinical problem. Thus, further...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2018-09, Vol.22 (9), p.4161-4170
Hauptverfasser:	Liu, Zhenhua, Zhang, Jinghang, Xu, Juntao, Yang, Huijie, Li, Xin, Hou, Yingxiang, Zhao, Yan, Xue, Min, Wang, Beibei, Yu, Na, Yu, Sifan, Niu, Gang, Wu, Gaosong, Li, Xiumin, Wang, Hui, Zhu, Jian, Zhuang, Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Proliferation ER ɑ Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Female Gene Expression Regulation, Neoplastic Humans MCF-7 Cells Membrane Proteins Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Original Presenilin-2 - genetics Presenilin-2 - metabolism Promoter Regions, Genetic Protein Binding RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNF168 Signal Transduction Survival Analysis transcription Transcription, Genetic Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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