One-step process for production of N-methylated amino acids from sugars and methylamine using recombinant Corynebacterium glutamicum as biocatalyst

N -methylated amino acids are found in Nature in various biological compounds. N -methylation of amino acids has been shown to improve pharmacokinetic properties of peptide drugs due to conformational changes, improved proteolytic stability and/or higher lipophilicity. Due to these characteristics N...

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Veröffentlicht in:Scientific reports 2018-08, Vol.8 (1), p.12895-11, Article 12895
Hauptverfasser: Mindt, Melanie, Risse, Joe Max, Gruß, Hendrik, Sewald, Norbert, Eikmanns, Bernhard J., Wendisch, Volker F.
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Sprache:eng
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