Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

In a rat ex vivo acute glaucoma model, high pressure (75 mmHg) causes swelling of ganglion cell axons and elevates levels of the endogenous steroids 24(S)-hydroxycholesterol (24SH) and allopregnanolone (AlloP). Furthermore, 24SH (0.1 µM) alone elevates AlloP levels via NMDA receptors. With this mode...

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Veröffentlicht in:	Scientific reports 2018-08, Vol.8 (1), p.12851-15, Article 12851
Hauptverfasser:	Ishikawa, Makoto, Yoshitomi, Takeshi, Covey, Douglas F., Zorumski, Charles F., Izumi, Yukitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/51 631/378/2613/1786 692/617/375 Axons Excitotoxicity Glaucoma Glutamic acid receptors (ionotropic) High pressure Humanities and Social Sciences multidisciplinary N-Methyl-D-aspartic acid receptors Neuroprotection Neurosteroids Pregnanolone Pressure Science Science (multidisciplinary) Steroid hormones Voriconazole γ-Aminobutyric acid A receptors
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