Levocetirizine Pretreatment Mitigates Lipopolysaccharide-Induced Lung Inflammation in Rats

This research was conducted to investigate possible protective influences of levocetirizine, a nonsedating H1 antihistamine, against lipopolysaccharide (LPS)-induced lung injury in rats. Male Sprague Dawley rats received either levocetirizine (1 mg/kg/day, orally) or the vehicle of the drug (2 ml/kg...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-9
Hauptverfasser:	Fahmi, Alaa N. A., Salem, Hatem A., Shehatou, George S. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - drug therapy Alveoli Animal experimentation Animals Antioxidants Bronchoalveolar Lavage Fluid Bronchus C-reactive protein Cetirizine - pharmacology Edema Fuel consumption Gene expression Histamine H1 Antagonists, Non-Sedating - pharmacology Immunology Infiltration Inflammation Inflammation - drug therapy Kinases L-Lactate dehydrogenase Laboratory animals Lactate dehydrogenase Lactic acid Leukocytes Lipopolysaccharides Lung - immunology Lung - pathology Lungs Male Malondialdehyde Metastases Mitogens Mortality Neutrophils Nitrogen oxide Oxidative stress Pneumonia Proteins Rats Rats, Sprague-Dawley Rodents Sepsis Superoxide Superoxide dismutase Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF Tumor necrosis factor-α Variance analysis Weight
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