Preponderance of endometrial carcinoma in elderly patients
Elderly patients with endometrial carcinoma (EMC) are considered to have a poor clinical outcome. The present study included 79 patients aged ≥70 years with EMC stage I or II according to the International Federation of Gynecology and Obstetrics classification, and it was conducted to analyse the cl...
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| Veröffentlicht in: | Molecular and clinical oncology 2018-09, Vol.9 (3), p.269-273 |
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| container_title | Molecular and clinical oncology |
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| creator | Ogane, Naoki Hori, Shin-Ichi Yano, Mitsutake Katoh, Tomomi Kamoshida, Shingo Kato, Hisamori Kameda, Yoichi Yasuda, Masanori |
| description | Elderly patients with endometrial carcinoma (EMC) are considered to have a poor clinical outcome. The present study included 79 patients aged ≥70 years with EMC stage I or II according to the International Federation of Gynecology and Obstetrics classification, and it was conducted to analyse the clinicopathological significance of histological type (I or II), depth of myometrial invasion ( |
| doi_str_mv | 10.3892/mco.2018.1680 |
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The present study included 79 patients aged ≥70 years with EMC stage I or II according to the International Federation of Gynecology and Obstetrics classification, and it was conducted to analyse the clinicopathological significance of histological type (I or II), depth of myometrial invasion (<1/2 or ≥1/2), lymphovascular invasion (+ or -) and immunohistochemical profile. The aim of these analyses was to determine whether these factors may adversely affect the patient outcome and the underlying mechanisms. The immunohistochemical markers used were estrogen receptor (ER), Ki-67 and p53. The expression of these markers was evaluated as high (+) or low (-). Accordingly, the patients were divided into groups as follows: 54 cases type I vs. 25 cases type II; 48 cases with myometrial invasion <1/2 vs. 31 cases without myometrial invasion ≥1/2; 63 cases with lymphovascular invasion vs. 16 cases without lymphovascular invasion; 57 cases with ER (+) vs. 22 cases with ER (-); 24 cases with Ki-67 (+) vs. 55 cases with Ki-67 (-); and 29 cases with p53 (+) vs. 50 cases with p53 (-). In conclusion, close attention must be paid to elderly patients with EMC due to the tumor's intrinsic aggressiveness, which may include the ER (-) and p53 (+) pattern as an independent poor prognostic factor.</description><identifier>ISSN: 2049-9450</identifier><identifier>EISSN: 2049-9469</identifier><identifier>DOI: 10.3892/mco.2018.1680</identifier><identifier>PMID: 30155248</identifier><language>eng</language><publisher>England: Spandidos Publications</publisher><subject>Age ; Cancer ; Cancer research ; Care and treatment ; Development and progression ; Elderly patients ; Endometrial cancer ; Medical prognosis ; Multivariate analysis ; Older people ; Oncology ; Patients</subject><ispartof>Molecular and clinical oncology, 2018-09, Vol.9 (3), p.269-273</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Ogane et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-7de91b47dc80846229d960ba43da0fbed9b027624c77b6e93abc82d6018cf9ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109667/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109667/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30155248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogane, Naoki</creatorcontrib><creatorcontrib>Hori, Shin-Ichi</creatorcontrib><creatorcontrib>Yano, Mitsutake</creatorcontrib><creatorcontrib>Katoh, Tomomi</creatorcontrib><creatorcontrib>Kamoshida, Shingo</creatorcontrib><creatorcontrib>Kato, Hisamori</creatorcontrib><creatorcontrib>Kameda, Yoichi</creatorcontrib><creatorcontrib>Yasuda, Masanori</creatorcontrib><title>Preponderance of endometrial carcinoma in elderly patients</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>Elderly patients with endometrial carcinoma (EMC) are considered to have a poor clinical outcome. The present study included 79 patients aged ≥70 years with EMC stage I or II according to the International Federation of Gynecology and Obstetrics classification, and it was conducted to analyse the clinicopathological significance of histological type (I or II), depth of myometrial invasion (<1/2 or ≥1/2), lymphovascular invasion (+ or -) and immunohistochemical profile. The aim of these analyses was to determine whether these factors may adversely affect the patient outcome and the underlying mechanisms. The immunohistochemical markers used were estrogen receptor (ER), Ki-67 and p53. The expression of these markers was evaluated as high (+) or low (-). Accordingly, the patients were divided into groups as follows: 54 cases type I vs. 25 cases type II; 48 cases with myometrial invasion <1/2 vs. 31 cases without myometrial invasion ≥1/2; 63 cases with lymphovascular invasion vs. 16 cases without lymphovascular invasion; 57 cases with ER (+) vs. 22 cases with ER (-); 24 cases with Ki-67 (+) vs. 55 cases with Ki-67 (-); and 29 cases with p53 (+) vs. 50 cases with p53 (-). In conclusion, close attention must be paid to elderly patients with EMC due to the tumor's intrinsic aggressiveness, which may include the ER (-) and p53 (+) pattern as an independent poor prognostic factor.</description><subject>Age</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Care and treatment</subject><subject>Development and progression</subject><subject>Elderly patients</subject><subject>Endometrial cancer</subject><subject>Medical prognosis</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Oncology</subject><subject>Patients</subject><issn>2049-9450</issn><issn>2049-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1PxCAQhonR6Eb36NU08eKlK4WWggcTY_xKNtGDngmFqbJpYYWuif9e1tXVNcKBCTzzDjMvQocFnlAuyGmv_YTggk8KxvEWGhFcilyUTGyv4wrvoXGMM5yWqDGpxC7ao7ioKlLyETp7CDD3zkBQTkPm2wyc8T0Mwaou0ypo63yvMusy6BLVvWdzNVhwQzxAO63qIoy_zn30dH31eHmbT-9v7i4vprmmjA95bUAUTVkbzTEvGSHCCIYbVVKjcNuAEQ0mNSOlruuGgaCq0ZwYltrSrVBA99H5Sne-aHowOtUOqpPzYHsV3qVXVm6-OPsin_2bZAUWjNVJ4ORLIPjXBcRB9jZq6DrlwC-iJAmr0jyoSOjxH3TmF8Gl9j4pwmn66w_1rDqQ1rU-1dVLUXlRVZRwTClJ1OQfKm0DvdXeQWvT_UZCvkrQwccYoF33WGC59Fsmv-XSb7n0O_FHvwezpr_dpR_emKTK</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Ogane, Naoki</creator><creator>Hori, Shin-Ichi</creator><creator>Yano, Mitsutake</creator><creator>Katoh, Tomomi</creator><creator>Kamoshida, Shingo</creator><creator>Kato, Hisamori</creator><creator>Kameda, Yoichi</creator><creator>Yasuda, Masanori</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Preponderance of endometrial carcinoma in elderly patients</title><author>Ogane, Naoki ; Hori, Shin-Ichi ; Yano, Mitsutake ; Katoh, Tomomi ; Kamoshida, Shingo ; Kato, Hisamori ; Kameda, Yoichi ; Yasuda, Masanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-7de91b47dc80846229d960ba43da0fbed9b027624c77b6e93abc82d6018cf9ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Care and treatment</topic><topic>Development and progression</topic><topic>Elderly patients</topic><topic>Endometrial cancer</topic><topic>Medical prognosis</topic><topic>Multivariate analysis</topic><topic>Older people</topic><topic>Oncology</topic><topic>Patients</topic><toplevel>online_resources</toplevel><creatorcontrib>Ogane, Naoki</creatorcontrib><creatorcontrib>Hori, Shin-Ichi</creatorcontrib><creatorcontrib>Yano, Mitsutake</creatorcontrib><creatorcontrib>Katoh, Tomomi</creatorcontrib><creatorcontrib>Kamoshida, Shingo</creatorcontrib><creatorcontrib>Kato, Hisamori</creatorcontrib><creatorcontrib>Kameda, Yoichi</creatorcontrib><creatorcontrib>Yasuda, Masanori</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogane, Naoki</au><au>Hori, Shin-Ichi</au><au>Yano, Mitsutake</au><au>Katoh, Tomomi</au><au>Kamoshida, Shingo</au><au>Kato, Hisamori</au><au>Kameda, Yoichi</au><au>Yasuda, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preponderance of endometrial carcinoma in elderly patients</atitle><jtitle>Molecular and clinical oncology</jtitle><addtitle>Mol Clin Oncol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>9</volume><issue>3</issue><spage>269</spage><epage>273</epage><pages>269-273</pages><issn>2049-9450</issn><eissn>2049-9469</eissn><abstract>Elderly patients with endometrial carcinoma (EMC) are considered to have a poor clinical outcome. The present study included 79 patients aged ≥70 years with EMC stage I or II according to the International Federation of Gynecology and Obstetrics classification, and it was conducted to analyse the clinicopathological significance of histological type (I or II), depth of myometrial invasion (<1/2 or ≥1/2), lymphovascular invasion (+ or -) and immunohistochemical profile. The aim of these analyses was to determine whether these factors may adversely affect the patient outcome and the underlying mechanisms. The immunohistochemical markers used were estrogen receptor (ER), Ki-67 and p53. The expression of these markers was evaluated as high (+) or low (-). Accordingly, the patients were divided into groups as follows: 54 cases type I vs. 25 cases type II; 48 cases with myometrial invasion <1/2 vs. 31 cases without myometrial invasion ≥1/2; 63 cases with lymphovascular invasion vs. 16 cases without lymphovascular invasion; 57 cases with ER (+) vs. 22 cases with ER (-); 24 cases with Ki-67 (+) vs. 55 cases with Ki-67 (-); and 29 cases with p53 (+) vs. 50 cases with p53 (-). In conclusion, close attention must be paid to elderly patients with EMC due to the tumor's intrinsic aggressiveness, which may include the ER (-) and p53 (+) pattern as an independent poor prognostic factor.</abstract><cop>England</cop><pub>Spandidos Publications</pub><pmid>30155248</pmid><doi>10.3892/mco.2018.1680</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Cancer Cancer research Care and treatment Development and progression Elderly patients Endometrial cancer Medical prognosis Multivariate analysis Older people Oncology Patients |
| title | Preponderance of endometrial carcinoma in elderly patients |
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