Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis

Cutaneous wounds in adult mammals typically heal by scarring. However, large full-thickness wounds undergo wound-induced hair follicle neogenesis (WIHN), a form of regeneration. Here, we show that WIHN requires transient expression of epidermal Msx2 in two phases: the wound margin early and the woun...

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Veröffentlicht in:	Journal of investigative dermatology 2018-09, Vol.138 (9), p.2041-2050
Hauptverfasser:	Hughes, Michael W., Jiang, Ting-Xin, Plikus, Maksim V., Guerrero-Juarez, Christian Fernando, Lin, Chien-Hong, Schafer, Christopher, Maxson, Robert, Widelitz, Randall B., Chuong, Cheng-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Gene Expression Regulation Hair Follicle - metabolism Hair Follicle - pathology Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Mice, Inbred C57BL Mice, SCID Regeneration - physiology RNA - genetics Signal Transduction Skin - injuries Skin - metabolism Skin - pathology Wound Healing - genetics Wounds and Injuries - complications Wounds and Injuries - genetics Wounds and Injuries - metabolism
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