Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention
Abstract Objective to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty. Design a cross-sectional study. Setting the Irish Longitudinal Study on Ageing (TILDA). Participants frailty measures were obtained on 5,618 participants and a subset of 4,330...
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| Veröffentlicht in: | Age and ageing 2018-09, Vol.47 (5), p.714-720 |
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| creator | Wong, Tsz Yan Massa, M Sofia O'Halloran, Aisling M Kenny, Rose Ann Clarke, Robert |
| description | Abstract
Objective
to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty.
Design
a cross-sectional study.
Setting
the Irish Longitudinal Study on Ageing (TILDA).
Participants
frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD.
Exposures for observational study
cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM]).
Main outcome measures
a frailty index (40-items) was used to screen for frailty.
Methods
the associations of CVD risk factors with frailty were examined using logistic regression.
Results
overall, 16.4% of participants had frailty (7.6% at 50–59 years to 42.5% at 80+ years), and the prevalence was higher in those with versus those without prior CVD (43.0% vs. 10.7%). Among those without prior CVD, mean levels of CVD risk factors were closely correlated with higher frailty index scores. Combined CVD risk factors, assessed using SCORE, were linearly and positively associated with frailty. Compared to low-to-moderate SCOREs, the odds ratio (OR) (95% confidence interval, CI) of frailty for those with very high risk was 3.18 (2.38–4.25). Conversely, ICH was linearly and inversely associated with frailty, with an OR for optimal health of 0.29 (0.21–0.40) compared with inadequate health.
Conclusions
the concordant positive associations of SCORE and inverse associations of ICH and CHM with frailty highlight the potential importance of optimum levels of CVD risk factors for prevention of disability in frail older people. |
| doi_str_mv | 10.1093/ageing/afy080 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6108388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ageing/afy080</oup_id><sourcerecordid>2306236190</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-1779c6caa728a90f41cf036649a7bbb4feefcb4502bedfb96c582772b13cd8293</originalsourceid><addsrcrecordid>eNqFkbtvFDEQxq2IiBwJJS2yREOziR-7flAgoRMQpEg0pLZmvfbh4Fsv9u5J99_j45LwaFKNRvPTNzPfh9ArSi4p0fwKNi6Mmyvwe6LICVrRVqiGKd4-QytCCGuIZPoMvSjlrra0o-w5OmNaaiGIXKG0hjyEtINilwgZ51B-YA92TrlgGAfsM4Q473EYMWCbUylNcXYOaYSIy7wMe5w8TnFwGU8uTdG9w2E7xWDhABXsUx1kt3Pjob9Apx5icS_v6zm6_fTx2_q6ufn6-cv6w01jO9rODZVSW2EBJFOgiW-p9YQL0WqQfd-33jlv-7YjrHeD77WwnWJSsp5yOyim-Tl6f9Sdln7rBlu3Z4hmymELeW8SBPPvZAzfzSbtjKBEcaWqwNt7gZx-Lq7MZhuKdTHC6NJSDCNtxySXSlb0zX_oXVpy9adSnAjGBdWkUs2R-m1idv7xGErMIUpzjNIco6z8678_eKQfsvtzYVqmJ7R-AfEMrQM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2306236190</pqid></control><display><type>article</type><title>Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Wong, Tsz Yan ; Massa, M Sofia ; O'Halloran, Aisling M ; Kenny, Rose Ann ; Clarke, Robert</creator><creatorcontrib>Wong, Tsz Yan ; Massa, M Sofia ; O'Halloran, Aisling M ; Kenny, Rose Ann ; Clarke, Robert</creatorcontrib><description>Abstract
Objective
to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty.
Design
a cross-sectional study.
Setting
the Irish Longitudinal Study on Ageing (TILDA).
Participants
frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD.
Exposures for observational study
cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM]).
Main outcome measures
a frailty index (40-items) was used to screen for frailty.
Methods
the associations of CVD risk factors with frailty were examined using logistic regression.
Results
overall, 16.4% of participants had frailty (7.6% at 50–59 years to 42.5% at 80+ years), and the prevalence was higher in those with versus those without prior CVD (43.0% vs. 10.7%). Among those without prior CVD, mean levels of CVD risk factors were closely correlated with higher frailty index scores. Combined CVD risk factors, assessed using SCORE, were linearly and positively associated with frailty. Compared to low-to-moderate SCOREs, the odds ratio (OR) (95% confidence interval, CI) of frailty for those with very high risk was 3.18 (2.38–4.25). Conversely, ICH was linearly and inversely associated with frailty, with an OR for optimal health of 0.29 (0.21–0.40) compared with inadequate health.
Conclusions
the concordant positive associations of SCORE and inverse associations of ICH and CHM with frailty highlight the potential importance of optimum levels of CVD risk factors for prevention of disability in frail older people.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afy080</identifier><identifier>PMID: 29796607</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Activities of Daily Living ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Associations ; Cardiovascular diseases ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - economics ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - therapy ; Controlled Clinical Trials as Topic ; Cost-Benefit Analysis ; Cross-Sectional Studies ; Delivery of Health Care, Integrated - economics ; Disability ; Female ; Frail ; Frail Elderly ; Frailty ; Frailty - diagnosis ; Frailty - economics ; Frailty - epidemiology ; Frailty - therapy ; General Practice - economics ; Health Care Costs ; Health risk assessment ; High risk ; Humans ; Male ; Netherlands - epidemiology ; Older people ; Primary Health Care - economics ; Prognosis ; Quality of Life ; Research Paper ; Risk Assessment ; Risk Factors ; Social Behavior</subject><ispartof>Age and ageing, 2018-09, Vol.47 (5), p.714-720</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the British Geriatrics Society. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the British Geriatrics Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-1779c6caa728a90f41cf036649a7bbb4feefcb4502bedfb96c582772b13cd8293</citedby><cites>FETCH-LOGICAL-c514t-1779c6caa728a90f41cf036649a7bbb4feefcb4502bedfb96c582772b13cd8293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1583,27923,27924,30998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29796607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Tsz Yan</creatorcontrib><creatorcontrib>Massa, M Sofia</creatorcontrib><creatorcontrib>O'Halloran, Aisling M</creatorcontrib><creatorcontrib>Kenny, Rose Ann</creatorcontrib><creatorcontrib>Clarke, Robert</creatorcontrib><title>Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>Abstract
Objective
to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty.
Design
a cross-sectional study.
Setting
the Irish Longitudinal Study on Ageing (TILDA).
Participants
frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD.
Exposures for observational study
cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM]).
Main outcome measures
a frailty index (40-items) was used to screen for frailty.
Methods
the associations of CVD risk factors with frailty were examined using logistic regression.
Results
overall, 16.4% of participants had frailty (7.6% at 50–59 years to 42.5% at 80+ years), and the prevalence was higher in those with versus those without prior CVD (43.0% vs. 10.7%). Among those without prior CVD, mean levels of CVD risk factors were closely correlated with higher frailty index scores. Combined CVD risk factors, assessed using SCORE, were linearly and positively associated with frailty. Compared to low-to-moderate SCOREs, the odds ratio (OR) (95% confidence interval, CI) of frailty for those with very high risk was 3.18 (2.38–4.25). Conversely, ICH was linearly and inversely associated with frailty, with an OR for optimal health of 0.29 (0.21–0.40) compared with inadequate health.
Conclusions
the concordant positive associations of SCORE and inverse associations of ICH and CHM with frailty highlight the potential importance of optimum levels of CVD risk factors for prevention of disability in frail older people.</description><subject>Activities of Daily Living</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Associations</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - economics</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - therapy</subject><subject>Controlled Clinical Trials as Topic</subject><subject>Cost-Benefit Analysis</subject><subject>Cross-Sectional Studies</subject><subject>Delivery of Health Care, Integrated - economics</subject><subject>Disability</subject><subject>Female</subject><subject>Frail</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Frailty - diagnosis</subject><subject>Frailty - economics</subject><subject>Frailty - epidemiology</subject><subject>Frailty - therapy</subject><subject>General Practice - economics</subject><subject>Health Care Costs</subject><subject>Health risk assessment</subject><subject>High risk</subject><subject>Humans</subject><subject>Male</subject><subject>Netherlands - epidemiology</subject><subject>Older people</subject><subject>Primary Health Care - economics</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Research Paper</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Social Behavior</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkbtvFDEQxq2IiBwJJS2yREOziR-7flAgoRMQpEg0pLZmvfbh4Fsv9u5J99_j45LwaFKNRvPTNzPfh9ArSi4p0fwKNi6Mmyvwe6LICVrRVqiGKd4-QytCCGuIZPoMvSjlrra0o-w5OmNaaiGIXKG0hjyEtINilwgZ51B-YA92TrlgGAfsM4Q473EYMWCbUylNcXYOaYSIy7wMe5w8TnFwGU8uTdG9w2E7xWDhABXsUx1kt3Pjob9Apx5icS_v6zm6_fTx2_q6ufn6-cv6w01jO9rODZVSW2EBJFOgiW-p9YQL0WqQfd-33jlv-7YjrHeD77WwnWJSsp5yOyim-Tl6f9Sdln7rBlu3Z4hmymELeW8SBPPvZAzfzSbtjKBEcaWqwNt7gZx-Lq7MZhuKdTHC6NJSDCNtxySXSlb0zX_oXVpy9adSnAjGBdWkUs2R-m1idv7xGErMIUpzjNIco6z8678_eKQfsvtzYVqmJ7R-AfEMrQM</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Wong, Tsz Yan</creator><creator>Massa, M Sofia</creator><creator>O'Halloran, Aisling M</creator><creator>Kenny, Rose Ann</creator><creator>Clarke, Robert</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention</title><author>Wong, Tsz Yan ; Massa, M Sofia ; O'Halloran, Aisling M ; Kenny, Rose Ann ; Clarke, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-1779c6caa728a90f41cf036649a7bbb4feefcb4502bedfb96c582772b13cd8293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activities of Daily Living</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Associations</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - economics</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - therapy</topic><topic>Controlled Clinical Trials as Topic</topic><topic>Cost-Benefit Analysis</topic><topic>Cross-Sectional Studies</topic><topic>Delivery of Health Care, Integrated - economics</topic><topic>Disability</topic><topic>Female</topic><topic>Frail</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Frailty - diagnosis</topic><topic>Frailty - economics</topic><topic>Frailty - epidemiology</topic><topic>Frailty - therapy</topic><topic>General Practice - economics</topic><topic>Health Care Costs</topic><topic>Health risk assessment</topic><topic>High risk</topic><topic>Humans</topic><topic>Male</topic><topic>Netherlands - epidemiology</topic><topic>Older people</topic><topic>Primary Health Care - economics</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Research Paper</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Social Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Tsz Yan</creatorcontrib><creatorcontrib>Massa, M Sofia</creatorcontrib><creatorcontrib>O'Halloran, Aisling M</creatorcontrib><creatorcontrib>Kenny, Rose Ann</creatorcontrib><creatorcontrib>Clarke, Robert</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Tsz Yan</au><au>Massa, M Sofia</au><au>O'Halloran, Aisling M</au><au>Kenny, Rose Ann</au><au>Clarke, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>47</volume><issue>5</issue><spage>714</spage><epage>720</epage><pages>714-720</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><abstract>Abstract
Objective
to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty.
Design
a cross-sectional study.
Setting
the Irish Longitudinal Study on Ageing (TILDA).
Participants
frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD.
Exposures for observational study
cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM]).
Main outcome measures
a frailty index (40-items) was used to screen for frailty.
Methods
the associations of CVD risk factors with frailty were examined using logistic regression.
Results
overall, 16.4% of participants had frailty (7.6% at 50–59 years to 42.5% at 80+ years), and the prevalence was higher in those with versus those without prior CVD (43.0% vs. 10.7%). Among those without prior CVD, mean levels of CVD risk factors were closely correlated with higher frailty index scores. Combined CVD risk factors, assessed using SCORE, were linearly and positively associated with frailty. Compared to low-to-moderate SCOREs, the odds ratio (OR) (95% confidence interval, CI) of frailty for those with very high risk was 3.18 (2.38–4.25). Conversely, ICH was linearly and inversely associated with frailty, with an OR for optimal health of 0.29 (0.21–0.40) compared with inadequate health.
Conclusions
the concordant positive associations of SCORE and inverse associations of ICH and CHM with frailty highlight the potential importance of optimum levels of CVD risk factors for prevention of disability in frail older people.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29796607</pmid><doi>10.1093/ageing/afy080</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Age and ageing, 2018-09, Vol.47 (5), p.714-720 |
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| language | eng |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Activities of Daily Living Age Factors Aged Aged, 80 and over Aging Associations Cardiovascular diseases Cardiovascular Diseases - diagnosis Cardiovascular Diseases - economics Cardiovascular Diseases - epidemiology Cardiovascular Diseases - therapy Controlled Clinical Trials as Topic Cost-Benefit Analysis Cross-Sectional Studies Delivery of Health Care, Integrated - economics Disability Female Frail Frail Elderly Frailty Frailty - diagnosis Frailty - economics Frailty - epidemiology Frailty - therapy General Practice - economics Health Care Costs Health risk assessment High risk Humans Male Netherlands - epidemiology Older people Primary Health Care - economics Prognosis Quality of Life Research Paper Risk Assessment Risk Factors Social Behavior |
| title | Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention |
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