In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption

Abstract Mitochondria are dynamic organelles that undergo frequent fission and fusion events. Mitochondrial fission is required for ATP production, the tricarboxylic acid cycle, and processes beyond metabolism in a cell-type specific manner. Ex vivo and cell line studies have demonstrated that Drp1,...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2018-09, Vol.159 (9), p.3245-3256
Hauptverfasser:	Hennings, Thomas G, Chopra, Deeksha G, DeLeon, Elizabeth R, VanDeusen, Halena R, Sesaki, Hiromi, Merrins, Matthew J, Ku, Gregory M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Animals Beta cells Calcium Calcium (intracellular) Calcium - metabolism Calcium mobilization Clonal deletion Cre recombinase Dynamins - genetics Endocrinology Fasting - metabolism Fission Glucose Glucose Intolerance - genetics Hyperglycemia Hyperglycemia - genetics Ins1 gene Insulin Insulin secretion Insulin Secretion - genetics Insulin-Secreting Cells - metabolism Islets of Langerhans - metabolism Metabolism Mice Mice, Knockout Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondrial Dynamics Morphology Organelles Oxygen Oxygen consumption Oxygen Consumption - genetics Pancreas Secretion Tricarboxylic acid cycle
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