AMPK contributes to autophagosome maturation and lysosomal fusion

AMP-activated protein kinase (AMPK) regulates autophagy initiation when intracellular ATP level decreases. However, the role of AMPK during autophagosome maturation is not fully understood. Here, we report that AMPK contributes to efficient autophagosome maturation and lysosomal fusion. Using CRISPR...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2018-08, Vol.8 (1), p.12637-10, Article 12637
Hauptverfasser:	Jang, Minsu, Park, Rackhyun, Kim, Hyunju, Namkoong, Sim, Jo, Daum, Huh, Yang Hoon, Jang, Ik-Soon, Lee, Jin I., Park, Junsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/19 14/28 14/63 38/35 42/109 45/41 631/80/39/2346 631/80/86/2369 82 AMP AMP-activated protein kinase Autophagy Cell lines CRISPR Fusion protein Genome editing Glucose Humanities and Social Sciences Kinases Lysosomes multidisciplinary Phagocytosis Phagosomes Science Science (multidisciplinary) TOR protein Trehalose
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!