Age modification of ozone associations with cardiovascular disease risk in adults: a potential role for soluble P-selectin and blood pressure

Studies have suggested that age increases susceptibility to ozone-associated mortality, but the underlying mechanisms are unclear. In a previous study, personal exposure to ozone was significantly associated with a platelet activation biomarker, plasma soluble P-selectin (sCD62P), and blood pressure...

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Veröffentlicht in:Journal of thoracic disease 2018-07, Vol.10 (7), p.4643-4652
Hauptverfasser: Day, Drew B, Clyde, Merlise A, Xiang, Jianbang, Li, Feng, Cui, Xiaoxing, Mo, Jinhan, Gong, Jicheng, Weschler, Charles J, Zhang, Yinping, Zhang, Junfeng Jim
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container_end_page 4652
container_issue 7
container_start_page 4643
container_title Journal of thoracic disease
container_volume 10
creator Day, Drew B
Clyde, Merlise A
Xiang, Jianbang
Li, Feng
Cui, Xiaoxing
Mo, Jinhan
Gong, Jicheng
Weschler, Charles J
Zhang, Yinping
Zhang, Junfeng Jim
description Studies have suggested that age increases susceptibility to ozone-associated mortality, but the underlying mechanisms are unclear. In a previous study, personal exposure to ozone was significantly associated with a platelet activation biomarker, plasma soluble P-selectin (sCD62P), and blood pressure in 89 healthy adults, aged 22-52 years. The present study examines whether age modifies these associations in the same adults and in additional adults. Interaction terms of age and exposure were analyzed using hierarchical Bayesian mixed effects ridge regressions. Data from a similar additional study involving 71 healthy participants, aged 19-26 years, were pooled with the data from the first study to evaluate age effect modification when more young adults were added to the analysis. In the 89 adults, significant age interactions were observed for past 24-hour and 2-week ozone exposures and sCD62P. Based on the pooled data (89 plus 71 adults), a 10 ppb increase in 24-hour ozone exposure was associated with increases in sCD62P and systolic blood pressure (SBP) by 22.3% (95% CI: 14.3%, 31.2%) and 1.35 (-0.18, 2.84) mmHg, respectively, at age 25; these values increased to 48.6% (32.7%, 65.1%) and 4.98 (2.56, 7.35) mmHg, respectively, at age 40. These results mechanistically suggest that increasing age enhances cardiovascular effects of ozone.
doi_str_mv 10.21037/jtd.2018.06.135
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In a previous study, personal exposure to ozone was significantly associated with a platelet activation biomarker, plasma soluble P-selectin (sCD62P), and blood pressure in 89 healthy adults, aged 22-52 years. The present study examines whether age modifies these associations in the same adults and in additional adults. Interaction terms of age and exposure were analyzed using hierarchical Bayesian mixed effects ridge regressions. Data from a similar additional study involving 71 healthy participants, aged 19-26 years, were pooled with the data from the first study to evaluate age effect modification when more young adults were added to the analysis. In the 89 adults, significant age interactions were observed for past 24-hour and 2-week ozone exposures and sCD62P. 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title Age modification of ozone associations with cardiovascular disease risk in adults: a potential role for soluble P-selectin and blood pressure
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