Ndr kinases regulate retinal interneuron proliferation and homeostasis

Ndr2/Stk38l encodes a protein kinase associated with the Hippo tumor suppressor pathway and is mutated in a naturally-occurring canine early retinal degeneration (erd). To elucidate the retinal functions of Ndr2 and its paralog Ndr1/Stk38 , we generated Ndr1 and Ndr2 single knockout mice. Although r...

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Veröffentlicht in:	Scientific reports 2018-08, Vol.8 (1), p.12544-21, Article 12544
Hauptverfasser:	Léger, Hélène, Santana, Evelyn, Leu, N. Adrian, Smith, Eliot T., Beltran, William A., Aguirre, Gustavo D., Luca, Francis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14 14/19 38 38/91 42/41 45 45/91 631/208/135 631/80/83/2360 64 64/60 Amacrine cells Amacrine Cells - cytology Animals Cell Proliferation Clonal deletion ELAV-Like Protein 4 - metabolism Gene expression Gene Expression Regulation Homeostasis Humanities and Social Sciences Interneurons - cytology Interneurons - metabolism Kinases Lamination Mice, Inbred C57BL Mice, Knockout multidisciplinary Pax6 protein PAX6 Transcription Factor - metabolism Photoreceptor Cells - metabolism Protein kinase Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Retina Retina - cytology Retina - metabolism Retinal Bipolar Cells - cytology Retinal Bipolar Cells - metabolism Retinal degeneration Science Science (multidisciplinary) Synapses Tumor suppressor genes γ-Aminobutyric acid
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