The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial to mesenchymal transition; however, its role wi...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2018-08, Vol.49 (2), p.312-325.e5
Hauptverfasser:	Scott, Charlotte L., T’Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W.F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan, Guilliams, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cell Lineage - immunology Clec4f-cre Consortia Epithelial-Mesenchymal Transition Fc receptors Fcgr1-cre Female Gene expression Gene Expression Regulation, Neoplastic Genomics Genotype & phenotype Heterogeneity Identity Immune system Immunology Kupffer cells Kupffer Cells - cytology Kupffer Cells - immunology Life Sciences Liver - cytology Liver X Receptors - genetics Liver X Receptors - metabolism Lung - cytology LXRα Macrophage Macrophages Male Mesenchyme Mice Mice, Inbred C57BL Mice, Transgenic Osteoprogenitor cells Populations Replenishment Statistical analysis Transcription Factor Transcription factors ZEB2 Zinc Finger E-box Binding Homeobox 2 - genetics
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