Analysis of Postprandial Glycemia in Relation to Metabolic Compensation and Other Observed Parameters of Outpatients with Type 2 Diabetes Mellitus in the Czech Republic
Introduction The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and post...
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| Veröffentlicht in: | Diabetes therapy 2018-04, Vol.9 (2), p.665-672 |
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| creator | Žďárská, Denisa Janíčková Hill, Martin Kvapil, Milan Piťhová, Pavlína Brož, Jan |
| description | Introduction
The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and postprandial glucose levels.
Methods
The study included 1055 patients with type 2 diabetes mellitus. Their fasting plasma glucose and postprandial glucose were measured before and after a standardized breakfast. Attending diabetologists completed a uniform questionnaire that included demographic data, type of antidiabetic treatment, duration of diabetes, latest glycosylated hemoglobin value, presence of dyslipidemia, and organic complications.
Results
Glycosylated hemoglobin |
| doi_str_mv | 10.1007/s13300-018-0379-3 |
| format | Article |
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The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and postprandial glucose levels.
Methods
The study included 1055 patients with type 2 diabetes mellitus. Their fasting plasma glucose and postprandial glucose were measured before and after a standardized breakfast. Attending diabetologists completed a uniform questionnaire that included demographic data, type of antidiabetic treatment, duration of diabetes, latest glycosylated hemoglobin value, presence of dyslipidemia, and organic complications.
Results
Glycosylated hemoglobin < 53 mmol/mol was achieved in 363 (34.2%), postprandial glucose < 7.5 mmol/l in 211 (19.9%), and fasting plasma glucose < 6 mmol/l in 251 (23.7%) patients. Excellent metabolic compensation, indicated by all the above mentioned glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose values simultaneously, was achieved in only 71 (6.7%) patients. Comparable to fasting plasma glucose and postprandial glucose values, correlation with glycosylated hemoglobin levels is statistically significant; however, there is no difference at different glycosylated hemoglobin levels. There was a significant correlation between dyslipidemia and postprandial glycemia (
p
= 0.013).
Conclusion
The objective of care for patients with diabetes mellitus is to improve their long-term metabolic compensation; to that end, both fasting plasma glucose and postprandial glucose deserve equal attention.</description><identifier>ISSN: 1869-6953</identifier><identifier>EISSN: 1869-6961</identifier><identifier>DOI: 10.1007/s13300-018-0379-3</identifier><identifier>PMID: 29460257</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Antidiabetics ; Cardiology ; Diabetes ; Endocrinology ; Fasting ; Glucose ; Hyperglycemia ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolism ; Original Research ; Outpatient care facilities ; Plasma</subject><ispartof>Diabetes therapy, 2018-04, Vol.9 (2), p.665-672</ispartof><rights>The Author(s) 2018</rights><rights>Diabetes Therapy is a copyright of Springer, (2018). All Rights Reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-ef6aef778b2a6490667b25a06bdcabfd67bcffd7ac2570148dd249fc1d21aaa63</citedby><cites>FETCH-LOGICAL-c470t-ef6aef778b2a6490667b25a06bdcabfd67bcffd7ac2570148dd249fc1d21aaa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104280/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104280/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29460257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Žďárská, Denisa Janíčková</creatorcontrib><creatorcontrib>Hill, Martin</creatorcontrib><creatorcontrib>Kvapil, Milan</creatorcontrib><creatorcontrib>Piťhová, Pavlína</creatorcontrib><creatorcontrib>Brož, Jan</creatorcontrib><title>Analysis of Postprandial Glycemia in Relation to Metabolic Compensation and Other Observed Parameters of Outpatients with Type 2 Diabetes Mellitus in the Czech Republic</title><title>Diabetes therapy</title><addtitle>Diabetes Ther</addtitle><addtitle>Diabetes Ther</addtitle><description>Introduction
The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and postprandial glucose levels.
Methods
The study included 1055 patients with type 2 diabetes mellitus. Their fasting plasma glucose and postprandial glucose were measured before and after a standardized breakfast. Attending diabetologists completed a uniform questionnaire that included demographic data, type of antidiabetic treatment, duration of diabetes, latest glycosylated hemoglobin value, presence of dyslipidemia, and organic complications.
Results
Glycosylated hemoglobin < 53 mmol/mol was achieved in 363 (34.2%), postprandial glucose < 7.5 mmol/l in 211 (19.9%), and fasting plasma glucose < 6 mmol/l in 251 (23.7%) patients. Excellent metabolic compensation, indicated by all the above mentioned glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose values simultaneously, was achieved in only 71 (6.7%) patients. Comparable to fasting plasma glucose and postprandial glucose values, correlation with glycosylated hemoglobin levels is statistically significant; however, there is no difference at different glycosylated hemoglobin levels. There was a significant correlation between dyslipidemia and postprandial glycemia (
p
= 0.013).
Conclusion
The objective of care for patients with diabetes mellitus is to improve their long-term metabolic compensation; to that end, both fasting plasma glucose and postprandial glucose deserve equal attention.</description><subject>Antidiabetics</subject><subject>Cardiology</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Hyperglycemia</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Original Research</subject><subject>Outpatient care facilities</subject><subject>Plasma</subject><issn>1869-6953</issn><issn>1869-6961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1ks9u1DAQxiMEolXpA3BBlrhwCdhO1okvSNUWClLRVqicrYkz6bpK4mA7RcsT8ZjMNmX5I-GLbc1vvm9GM1n2XPDXgvPqTRRFwXnORZ3zotJ58Sg7FrXSudJKPD68V8VRdhrjLadTaK2FeJodSV0qLlfVcfbjbIR-F11kvmNXPqYpwNg66NlFv7M4OGBuZJ-xh-T8yJJnnzBB43tn2doPE45xiVAW26QtBrZpIoY7bNkVBBgwYbgX38xpIhTHFNk3l7bsejchk-zcQUNQJOG-d2mOe0MSYuvvaLdkPc0NuT3LnnTQRzx9uE-yL-_fXa8_5Jebi4_rs8vclhVPOXYKsKuqupGgSs2Vqhq5Aq6a1kLTtfS1XddWYKl9Lsq6bWWpOytaKQBAFSfZ20WXbAdsLdUboDdTcAOEnfHgzN-R0W3Njb8zSvBS1pwEXj0IBP91xpjM4KKl3mBEP0cjaXhCKF3WhL78B731c6CB3FOFXJWFLIkSC2WDjzFgdyhGcLNfBbOsgqFVMPtVMAXlvPizi0PGr8ETIBcgUmi8wfDb-v-qPwFTVMLX</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Žďárská, Denisa Janíčková</creator><creator>Hill, Martin</creator><creator>Kvapil, Milan</creator><creator>Piťhová, Pavlína</creator><creator>Brož, Jan</creator><general>Springer Healthcare</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Analysis of Postprandial Glycemia in Relation to Metabolic Compensation and Other Observed Parameters of Outpatients with Type 2 Diabetes Mellitus in the Czech Republic</title><author>Žďárská, Denisa Janíčková ; Hill, Martin ; Kvapil, Milan ; Piťhová, Pavlína ; Brož, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-ef6aef778b2a6490667b25a06bdcabfd67bcffd7ac2570148dd249fc1d21aaa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antidiabetics</topic><topic>Cardiology</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Fasting</topic><topic>Glucose</topic><topic>Hyperglycemia</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Original Research</topic><topic>Outpatient care facilities</topic><topic>Plasma</topic><toplevel>online_resources</toplevel><creatorcontrib>Žďárská, Denisa Janíčková</creatorcontrib><creatorcontrib>Hill, Martin</creatorcontrib><creatorcontrib>Kvapil, Milan</creatorcontrib><creatorcontrib>Piťhová, Pavlína</creatorcontrib><creatorcontrib>Brož, Jan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Žďárská, Denisa Janíčková</au><au>Hill, Martin</au><au>Kvapil, Milan</au><au>Piťhová, Pavlína</au><au>Brož, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Postprandial Glycemia in Relation to Metabolic Compensation and Other Observed Parameters of Outpatients with Type 2 Diabetes Mellitus in the Czech Republic</atitle><jtitle>Diabetes therapy</jtitle><stitle>Diabetes Ther</stitle><addtitle>Diabetes Ther</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>9</volume><issue>2</issue><spage>665</spage><epage>672</epage><pages>665-672</pages><issn>1869-6953</issn><eissn>1869-6961</eissn><abstract>Introduction
The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and postprandial glucose levels.
Methods
The study included 1055 patients with type 2 diabetes mellitus. Their fasting plasma glucose and postprandial glucose were measured before and after a standardized breakfast. Attending diabetologists completed a uniform questionnaire that included demographic data, type of antidiabetic treatment, duration of diabetes, latest glycosylated hemoglobin value, presence of dyslipidemia, and organic complications.
Results
Glycosylated hemoglobin < 53 mmol/mol was achieved in 363 (34.2%), postprandial glucose < 7.5 mmol/l in 211 (19.9%), and fasting plasma glucose < 6 mmol/l in 251 (23.7%) patients. Excellent metabolic compensation, indicated by all the above mentioned glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose values simultaneously, was achieved in only 71 (6.7%) patients. Comparable to fasting plasma glucose and postprandial glucose values, correlation with glycosylated hemoglobin levels is statistically significant; however, there is no difference at different glycosylated hemoglobin levels. There was a significant correlation between dyslipidemia and postprandial glycemia (
p
= 0.013).
Conclusion
The objective of care for patients with diabetes mellitus is to improve their long-term metabolic compensation; to that end, both fasting plasma glucose and postprandial glucose deserve equal attention.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>29460257</pmid><doi>10.1007/s13300-018-0379-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes therapy, 2018-04, Vol.9 (2), p.665-672 |
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| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antidiabetics Cardiology Diabetes Endocrinology Fasting Glucose Hyperglycemia Internal Medicine Medicine Medicine & Public Health Metabolism Original Research Outpatient care facilities Plasma |
| title | Analysis of Postprandial Glycemia in Relation to Metabolic Compensation and Other Observed Parameters of Outpatients with Type 2 Diabetes Mellitus in the Czech Republic |
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