Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy
Cow’s milk allergy (CMA) is one of the earliest and most common food allergy and can be elicited by both IgE- or non-IgE-mediated mechanism. We previously described dysbiosis in children with IgE-mediated CMA and the effect of dietary treatment with extensively hydrolyzed casein formula (EHCF) alone...
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| Veröffentlicht in: | Scientific reports 2018-08, Vol.8 (1), p.12500-10, Article 12500 |
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| creator | Berni Canani, Roberto De Filippis, Francesca Nocerino, Rita Paparo, Lorella Di Scala, Carmen Cosenza, Linda Della Gatta, Giusy Calignano, Antonio De Caro, Carmen Laiola, Manolo Gilbert, Jack A. Ercolini, Danilo |
| description | Cow’s milk allergy (CMA) is one of the earliest and most common food allergy and can be elicited by both IgE- or non-IgE-mediated mechanism. We previously described dysbiosis in children with IgE-mediated CMA and the effect of dietary treatment with extensively hydrolyzed casein formula (EHCF) alone or in combination with the probiotic
Lactobacillus rhamnosus
GG (LGG). On the contrary, the gut microbiota in non-IgE-mediated CMA remains uncharacterized. In this study we evaluated gut microbiota composition and fecal butyrate levels in children affected by non-IgE-mediated CMA. We found a gut microbiota dysbiosis in non-IgE-mediated CMA, driven by an enrichment of
Bacteroides
and
Alistipes
. Comparing these results with those previously obtained in children with IgE-mediated CMA, we demonstrated overlapping signatures in the gut microbiota dysbiosis of non-IgE-mediated and IgE-mediated CMA children, characterized by a progressive increase in
Bacteroides
from healthy to IgE-mediated CMA patients. EHCF containg LGG was more strongly associated with an effect on dysbiosis and on butyrate production if compared to what observed in children treated with EHCF alone. If longitudinal cohort studies in children with CMA will confirm these results, gut microbiota dysbiosis could be a relevant target for innovative therapeutic strategies in children with non-IgE-mediated CMA. |
| doi_str_mv | 10.1038/s41598-018-30428-3 |
| format | Article |
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Lactobacillus rhamnosus
GG (LGG). On the contrary, the gut microbiota in non-IgE-mediated CMA remains uncharacterized. In this study we evaluated gut microbiota composition and fecal butyrate levels in children affected by non-IgE-mediated CMA. We found a gut microbiota dysbiosis in non-IgE-mediated CMA, driven by an enrichment of
Bacteroides
and
Alistipes
. Comparing these results with those previously obtained in children with IgE-mediated CMA, we demonstrated overlapping signatures in the gut microbiota dysbiosis of non-IgE-mediated and IgE-mediated CMA children, characterized by a progressive increase in
Bacteroides
from healthy to IgE-mediated CMA patients. EHCF containg LGG was more strongly associated with an effect on dysbiosis and on butyrate production if compared to what observed in children treated with EHCF alone. If longitudinal cohort studies in children with CMA will confirm these results, gut microbiota dysbiosis could be a relevant target for innovative therapeutic strategies in children with non-IgE-mediated CMA.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-30428-3</identifier><identifier>PMID: 30131575</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/22 ; 45/23 ; 45/77 ; 631/114/2163 ; 631/326/2565/2142 ; 692/308/3187 ; Allergies ; Bacteroides ; BASIC BIOLOGICAL SCIENCES ; Casein ; Children ; Cow's milk ; Dysbacteriosis ; Food allergies ; Humanities and Social Sciences ; Immunoglobulin E ; Intestinal microflora ; Medical innovations ; Membrane reactors ; Microbiota ; Milk ; multidisciplinary ; Probiotics ; Science ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Termites</subject><ispartof>Scientific reports, 2018-08, Vol.8 (1), p.12500-10, Article 12500</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-406ea5a85af6e19cb687ba2b92a533cdc3e6fbe38aa74d810e2dc7ceced424de3</citedby><cites>FETCH-LOGICAL-c567t-406ea5a85af6e19cb687ba2b92a533cdc3e6fbe38aa74d810e2dc7ceced424de3</cites><orcidid>0000-0002-5169-9574 ; 0000-0002-3474-2884 ; 0000000251699574 ; 0000000234742884</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104073/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104073/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30131575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/servlets/purl/1624415$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Berni Canani, Roberto</creatorcontrib><creatorcontrib>De Filippis, Francesca</creatorcontrib><creatorcontrib>Nocerino, Rita</creatorcontrib><creatorcontrib>Paparo, Lorella</creatorcontrib><creatorcontrib>Di Scala, Carmen</creatorcontrib><creatorcontrib>Cosenza, Linda</creatorcontrib><creatorcontrib>Della Gatta, Giusy</creatorcontrib><creatorcontrib>Calignano, Antonio</creatorcontrib><creatorcontrib>De Caro, Carmen</creatorcontrib><creatorcontrib>Laiola, Manolo</creatorcontrib><creatorcontrib>Gilbert, Jack A.</creatorcontrib><creatorcontrib>Ercolini, Danilo</creatorcontrib><creatorcontrib>Argonne National Laboratory (ANL), Argonne, IL (United States)</creatorcontrib><title>Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Cow’s milk allergy (CMA) is one of the earliest and most common food allergy and can be elicited by both IgE- or non-IgE-mediated mechanism. We previously described dysbiosis in children with IgE-mediated CMA and the effect of dietary treatment with extensively hydrolyzed casein formula (EHCF) alone or in combination with the probiotic
Lactobacillus rhamnosus
GG (LGG). On the contrary, the gut microbiota in non-IgE-mediated CMA remains uncharacterized. In this study we evaluated gut microbiota composition and fecal butyrate levels in children affected by non-IgE-mediated CMA. We found a gut microbiota dysbiosis in non-IgE-mediated CMA, driven by an enrichment of
Bacteroides
and
Alistipes
. Comparing these results with those previously obtained in children with IgE-mediated CMA, we demonstrated overlapping signatures in the gut microbiota dysbiosis of non-IgE-mediated and IgE-mediated CMA children, characterized by a progressive increase in
Bacteroides
from healthy to IgE-mediated CMA patients. EHCF containg LGG was more strongly associated with an effect on dysbiosis and on butyrate production if compared to what observed in children treated with EHCF alone. If longitudinal cohort studies in children with CMA will confirm these results, gut microbiota dysbiosis could be a relevant target for innovative therapeutic strategies in children with non-IgE-mediated CMA.</description><subject>45</subject><subject>45/22</subject><subject>45/23</subject><subject>45/77</subject><subject>631/114/2163</subject><subject>631/326/2565/2142</subject><subject>692/308/3187</subject><subject>Allergies</subject><subject>Bacteroides</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Casein</subject><subject>Children</subject><subject>Cow's milk</subject><subject>Dysbacteriosis</subject><subject>Food allergies</subject><subject>Humanities and Social Sciences</subject><subject>Immunoglobulin E</subject><subject>Intestinal microflora</subject><subject>Medical innovations</subject><subject>Membrane reactors</subject><subject>Microbiota</subject><subject>Milk</subject><subject>multidisciplinary</subject><subject>Probiotics</subject><subject>Science</subject><subject>Science & Technology - 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Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berni Canani, Roberto</au><au>De Filippis, Francesca</au><au>Nocerino, Rita</au><au>Paparo, Lorella</au><au>Di Scala, Carmen</au><au>Cosenza, Linda</au><au>Della Gatta, Giusy</au><au>Calignano, Antonio</au><au>De Caro, Carmen</au><au>Laiola, Manolo</au><au>Gilbert, Jack A.</au><au>Ercolini, Danilo</au><aucorp>Argonne National Laboratory (ANL), Argonne, IL (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-08-21</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>12500</spage><epage>10</epage><pages>12500-10</pages><artnum>12500</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Cow’s milk allergy (CMA) is one of the earliest and most common food allergy and can be elicited by both IgE- or non-IgE-mediated mechanism. We previously described dysbiosis in children with IgE-mediated CMA and the effect of dietary treatment with extensively hydrolyzed casein formula (EHCF) alone or in combination with the probiotic
Lactobacillus rhamnosus
GG (LGG). On the contrary, the gut microbiota in non-IgE-mediated CMA remains uncharacterized. In this study we evaluated gut microbiota composition and fecal butyrate levels in children affected by non-IgE-mediated CMA. We found a gut microbiota dysbiosis in non-IgE-mediated CMA, driven by an enrichment of
Bacteroides
and
Alistipes
. Comparing these results with those previously obtained in children with IgE-mediated CMA, we demonstrated overlapping signatures in the gut microbiota dysbiosis of non-IgE-mediated and IgE-mediated CMA children, characterized by a progressive increase in
Bacteroides
from healthy to IgE-mediated CMA patients. EHCF containg LGG was more strongly associated with an effect on dysbiosis and on butyrate production if compared to what observed in children treated with EHCF alone. If longitudinal cohort studies in children with CMA will confirm these results, gut microbiota dysbiosis could be a relevant target for innovative therapeutic strategies in children with non-IgE-mediated CMA.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30131575</pmid><doi>10.1038/s41598-018-30428-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5169-9574</orcidid><orcidid>https://orcid.org/0000-0002-3474-2884</orcidid><orcidid>https://orcid.org/0000000251699574</orcidid><orcidid>https://orcid.org/0000000234742884</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 45 45/22 45/23 45/77 631/114/2163 631/326/2565/2142 692/308/3187 Allergies Bacteroides BASIC BIOLOGICAL SCIENCES Casein Children Cow's milk Dysbacteriosis Food allergies Humanities and Social Sciences Immunoglobulin E Intestinal microflora Medical innovations Membrane reactors Microbiota Milk multidisciplinary Probiotics Science Science & Technology - Other Topics Science (multidisciplinary) Termites |
| title | Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy |
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