Lupus Nephritis IgG Induction of Calcium/Calmodulin‐Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function

Objective Kidney podocytes and their slit diaphragms prevent urinary protein loss. T cells from patients with systemic lupus erythematosus display increased expression of calcium/calmodulin‐dependent protein kinase IV (CaMKIV). The present study was undertaken to investigate the role of CaMKIV in po...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2016-04, Vol.68 (4), p.944-952
Hauptverfasser:	Ichinose, Kunihiro, Ushigusa, Takeshi, Nishino, Ayako, Nakashima, Yosikazu, Suzuki, Takahisa, Horai, Yoshiro, Koga, Tomohiro, Kawashiri, Shin‐ya, Iwamoto, Naoki, Tamai, Mami, Arima, Kazuhiko, Nakamura, Hideki, Obata, Yoko, Yamamoto, Kazuo, Origuchi, Tomoki, Nishino, Tomoya, Kawakami, Atsushi, Tsokos, George C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals B7-2 Antigen - drug effects B7-2 Antigen - genetics B7-2 Antigen - metabolism Blotting, Western Calcium Calcium-Calmodulin-Dependent Protein Kinase Type 4 - drug effects Calcium-Calmodulin-Dependent Protein Kinase Type 4 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 4 - metabolism Female Fluorescent Antibody Technique Gene expression Gene Expression - drug effects Gene Expression Profiling Gene Knockdown Techniques Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Immunoglobulin G - pharmacology In Situ Hybridization In Vitro Techniques Kidney Glomerulus - metabolism Kinases Lupus Lupus Nephritis - immunology Lupus Nephritis - metabolism Membrane Proteins - metabolism Mice Mice, Inbred MRL lpr Mice, Knockout Middle Aged Oligonucleotide Array Sequence Analysis Podocytes - drug effects Podocytes - metabolism Proteins Receptors, Fc - genetics Receptors, Fc - metabolism Reverse Transcriptase Polymerase Chain Reaction Up-Regulation - drug effects Young Adult
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