No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children
Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate stud...
Gespeichert in:
| Veröffentlicht in: | Journal of child psychology and psychiatry 2016-12, Vol.57 (12), p.1455-1462 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1462 |
|---|---|
| container_issue | 12 |
| container_start_page | 1455 |
| container_title | Journal of child psychology and psychiatry |
| container_volume | 57 |
| creator | Kung, Karson T. F. Spencer, Debra Pasterski, Vickie Neufeld, Sharon Glover, Vivette O'Connor, Thomas G. Hindmarsh, Peter C. Hughes, Ieuan A. Acerini, Carlo L. Hines, Melissa |
| description | Background
There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis.
Methods
A parent‐report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years.
Results
Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample.
Conclusions
These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits.
Read the Commentary on this article at doi: 10.1111/jcpp.12628 |
| doi_str_mv | 10.1111/jcpp.12602 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6100761</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4266897641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4862-767ae0359b6565e3a7bf188a011f996708e118f6de8ebd1a699c4854f2e5c22e3</originalsourceid><addsrcrecordid>eNp9kt9u0zAUxiMEYt3ghgdAlrhBkzrs_HESLiahCgZoKpMA7dJynZPWxbWD7bTrA_MenDRbBVyQG0snv-_7jo9Pkrxg9ILh92atuu6CpZymj5IJy3k9LTmjj5MJpSmb1jyjJ8lpCGtKKc-K6mlykpY5p6yqJsmvuSMejIza2bDSHVlA3AFY0nmwMkpDpG28W2IF7joXeg9Dhcg-6hC1ItFLHcNbopzdgkcuEtjqBqwC0nq3ISH2jYZAXEvUSpsGfclOx9WgQFwfMoYqnqt9B74zMmh5SEGN3FjtDkEQogsRvLMwaBVG-bFvoi2J-04racyeNLAF4zptl8fAZ8mTVpoAz-_Ps-T7h_ffZh-n11-uPs3eXU9VXvEUx1ZKoFlRL3jBC8hkuWhxSpIy1tY1L2kFjFUtb6CCRcMkr2sUFnmbQqHSFLKz5HL07frFBpqxRSM6rzfS74WTWvz9x-qVWLqtwPei-Gho8PrewLufPd5YbHRQYIy04PogWJXyMqM8zRF99Q-6dr3HKQ5UXlBGq4wjdT5SyrsQPLTHZhgVw_aIYXvEYXsQfvln-0f0YV0QYCOw0wb2_7ESn2c3Nw-m01GD-wJ3R430PwRepSzE7fxK1PPbckarr6LIfgMQzed5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1845010836</pqid></control><display><type>article</type><title>No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kung, Karson T. F. ; Spencer, Debra ; Pasterski, Vickie ; Neufeld, Sharon ; Glover, Vivette ; O'Connor, Thomas G. ; Hindmarsh, Peter C. ; Hughes, Ieuan A. ; Acerini, Carlo L. ; Hines, Melissa</creator><creatorcontrib>Kung, Karson T. F. ; Spencer, Debra ; Pasterski, Vickie ; Neufeld, Sharon ; Glover, Vivette ; O'Connor, Thomas G. ; Hindmarsh, Peter C. ; Hughes, Ieuan A. ; Acerini, Carlo L. ; Hines, Melissa</creatorcontrib><description>Background
There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis.
Methods
A parent‐report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years.
Results
Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample.
Conclusions
These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits.
Read the Commentary on this article at doi: 10.1111/jcpp.12628</description><identifier>ISSN: 0021-9630</identifier><identifier>EISSN: 1469-7610</identifier><identifier>DOI: 10.1111/jcpp.12602</identifier><identifier>PMID: 27460188</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adrenal Hyperplasia, Congenital - metabolism ; Adrenal Hyperplasia, Congenital - physiopathology ; Amniotic Fluid - metabolism ; Androgens ; Antenatal ; Autism ; Autism Spectrum Disorder - etiology ; Autism Spectrum Disorder - metabolism ; Autism Spectrum Disorder - physiopathology ; Autistic children ; autistic traits ; Brain ; Child ; Child psychology ; Child, Preschool ; Childhood ; Children ; Congenital adrenal hyperplasia ; Congenital diseases ; extreme male brain ; Female ; Females ; Fetal exposure ; fetal testosterone ; Humans ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects - metabolism ; Prenatal Exposure Delayed Effects - physiopathology ; prenatal testosterone exposure ; Questionnaires ; Testosterone ; Testosterone - metabolism ; Young girls</subject><ispartof>Journal of child psychology and psychiatry, 2016-12, Vol.57 (12), p.1455-1462</ispartof><rights>2016 Association for Child and Adolescent Mental Health.</rights><rights>Copyright © 2016 Association for Child and Adolescent Mental Health.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4862-767ae0359b6565e3a7bf188a011f996708e118f6de8ebd1a699c4854f2e5c22e3</citedby><cites>FETCH-LOGICAL-c4862-767ae0359b6565e3a7bf188a011f996708e118f6de8ebd1a699c4854f2e5c22e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpp.12602$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpp.12602$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,30976,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27460188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kung, Karson T. F.</creatorcontrib><creatorcontrib>Spencer, Debra</creatorcontrib><creatorcontrib>Pasterski, Vickie</creatorcontrib><creatorcontrib>Neufeld, Sharon</creatorcontrib><creatorcontrib>Glover, Vivette</creatorcontrib><creatorcontrib>O'Connor, Thomas G.</creatorcontrib><creatorcontrib>Hindmarsh, Peter C.</creatorcontrib><creatorcontrib>Hughes, Ieuan A.</creatorcontrib><creatorcontrib>Acerini, Carlo L.</creatorcontrib><creatorcontrib>Hines, Melissa</creatorcontrib><title>No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children</title><title>Journal of child psychology and psychiatry</title><addtitle>J Child Psychol Psychiatr</addtitle><description>Background
There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis.
Methods
A parent‐report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years.
Results
Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample.
Conclusions
These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits.
Read the Commentary on this article at doi: 10.1111/jcpp.12628</description><subject>Adrenal Hyperplasia, Congenital - metabolism</subject><subject>Adrenal Hyperplasia, Congenital - physiopathology</subject><subject>Amniotic Fluid - metabolism</subject><subject>Androgens</subject><subject>Antenatal</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - etiology</subject><subject>Autism Spectrum Disorder - metabolism</subject><subject>Autism Spectrum Disorder - physiopathology</subject><subject>Autistic children</subject><subject>autistic traits</subject><subject>Brain</subject><subject>Child</subject><subject>Child psychology</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Congenital adrenal hyperplasia</subject><subject>Congenital diseases</subject><subject>extreme male brain</subject><subject>Female</subject><subject>Females</subject><subject>Fetal exposure</subject><subject>fetal testosterone</subject><subject>Humans</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>prenatal testosterone exposure</subject><subject>Questionnaires</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><subject>Young girls</subject><issn>0021-9630</issn><issn>1469-7610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp9kt9u0zAUxiMEYt3ghgdAlrhBkzrs_HESLiahCgZoKpMA7dJynZPWxbWD7bTrA_MenDRbBVyQG0snv-_7jo9Pkrxg9ILh92atuu6CpZymj5IJy3k9LTmjj5MJpSmb1jyjJ8lpCGtKKc-K6mlykpY5p6yqJsmvuSMejIza2bDSHVlA3AFY0nmwMkpDpG28W2IF7joXeg9Dhcg-6hC1ItFLHcNbopzdgkcuEtjqBqwC0nq3ISH2jYZAXEvUSpsGfclOx9WgQFwfMoYqnqt9B74zMmh5SEGN3FjtDkEQogsRvLMwaBVG-bFvoi2J-04racyeNLAF4zptl8fAZ8mTVpoAz-_Ps-T7h_ffZh-n11-uPs3eXU9VXvEUx1ZKoFlRL3jBC8hkuWhxSpIy1tY1L2kFjFUtb6CCRcMkr2sUFnmbQqHSFLKz5HL07frFBpqxRSM6rzfS74WTWvz9x-qVWLqtwPei-Gho8PrewLufPd5YbHRQYIy04PogWJXyMqM8zRF99Q-6dr3HKQ5UXlBGq4wjdT5SyrsQPLTHZhgVw_aIYXvEYXsQfvln-0f0YV0QYCOw0wb2_7ESn2c3Nw-m01GD-wJ3R430PwRepSzE7fxK1PPbckarr6LIfgMQzed5</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Kung, Karson T. F.</creator><creator>Spencer, Debra</creator><creator>Pasterski, Vickie</creator><creator>Neufeld, Sharon</creator><creator>Glover, Vivette</creator><creator>O'Connor, Thomas G.</creator><creator>Hindmarsh, Peter C.</creator><creator>Hughes, Ieuan A.</creator><creator>Acerini, Carlo L.</creator><creator>Hines, Melissa</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201612</creationdate><title>No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children</title><author>Kung, Karson T. F. ; Spencer, Debra ; Pasterski, Vickie ; Neufeld, Sharon ; Glover, Vivette ; O'Connor, Thomas G. ; Hindmarsh, Peter C. ; Hughes, Ieuan A. ; Acerini, Carlo L. ; Hines, Melissa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4862-767ae0359b6565e3a7bf188a011f996708e118f6de8ebd1a699c4854f2e5c22e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adrenal Hyperplasia, Congenital - metabolism</topic><topic>Adrenal Hyperplasia, Congenital - physiopathology</topic><topic>Amniotic Fluid - metabolism</topic><topic>Androgens</topic><topic>Antenatal</topic><topic>Autism</topic><topic>Autism Spectrum Disorder - etiology</topic><topic>Autism Spectrum Disorder - metabolism</topic><topic>Autism Spectrum Disorder - physiopathology</topic><topic>Autistic children</topic><topic>autistic traits</topic><topic>Brain</topic><topic>Child</topic><topic>Child psychology</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Congenital adrenal hyperplasia</topic><topic>Congenital diseases</topic><topic>extreme male brain</topic><topic>Female</topic><topic>Females</topic><topic>Fetal exposure</topic><topic>fetal testosterone</topic><topic>Humans</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - metabolism</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>prenatal testosterone exposure</topic><topic>Questionnaires</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><topic>Young girls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kung, Karson T. F.</creatorcontrib><creatorcontrib>Spencer, Debra</creatorcontrib><creatorcontrib>Pasterski, Vickie</creatorcontrib><creatorcontrib>Neufeld, Sharon</creatorcontrib><creatorcontrib>Glover, Vivette</creatorcontrib><creatorcontrib>O'Connor, Thomas G.</creatorcontrib><creatorcontrib>Hindmarsh, Peter C.</creatorcontrib><creatorcontrib>Hughes, Ieuan A.</creatorcontrib><creatorcontrib>Acerini, Carlo L.</creatorcontrib><creatorcontrib>Hines, Melissa</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of child psychology and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kung, Karson T. F.</au><au>Spencer, Debra</au><au>Pasterski, Vickie</au><au>Neufeld, Sharon</au><au>Glover, Vivette</au><au>O'Connor, Thomas G.</au><au>Hindmarsh, Peter C.</au><au>Hughes, Ieuan A.</au><au>Acerini, Carlo L.</au><au>Hines, Melissa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children</atitle><jtitle>Journal of child psychology and psychiatry</jtitle><addtitle>J Child Psychol Psychiatr</addtitle><date>2016-12</date><risdate>2016</risdate><volume>57</volume><issue>12</issue><spage>1455</spage><epage>1462</epage><pages>1455-1462</pages><issn>0021-9630</issn><eissn>1469-7610</eissn><abstract>Background
There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis.
Methods
A parent‐report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years.
Results
Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample.
Conclusions
These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits.
Read the Commentary on this article at doi: 10.1111/jcpp.12628</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27460188</pmid><doi>10.1111/jcpp.12602</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9630 |
| ispartof | Journal of child psychology and psychiatry, 2016-12, Vol.57 (12), p.1455-1462 |
| issn | 0021-9630 1469-7610 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6100761 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adrenal Hyperplasia, Congenital - metabolism Adrenal Hyperplasia, Congenital - physiopathology Amniotic Fluid - metabolism Androgens Antenatal Autism Autism Spectrum Disorder - etiology Autism Spectrum Disorder - metabolism Autism Spectrum Disorder - physiopathology Autistic children autistic traits Brain Child Child psychology Child, Preschool Childhood Children Congenital adrenal hyperplasia Congenital diseases extreme male brain Female Females Fetal exposure fetal testosterone Humans Male Pregnancy Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - physiopathology prenatal testosterone exposure Questionnaires Testosterone Testosterone - metabolism Young girls |
| title | No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T15%3A51%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=No%20relationship%20between%20prenatal%20androgen%20exposure%20and%20autistic%20traits:%20convergent%20evidence%20from%20studies%20of%20children%20with%20congenital%20adrenal%20hyperplasia%20and%20of%20amniotic%20testosterone%20concentrations%20in%20typically%20developing%20children&rft.jtitle=Journal%20of%20child%20psychology%20and%20psychiatry&rft.au=Kung,%20Karson%20T.%20F.&rft.date=2016-12&rft.volume=57&rft.issue=12&rft.spage=1455&rft.epage=1462&rft.pages=1455-1462&rft.issn=0021-9630&rft.eissn=1469-7610&rft_id=info:doi/10.1111/jcpp.12602&rft_dat=%3Cproquest_pubme%3E4266897641%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1845010836&rft_id=info:pmid/27460188&rfr_iscdi=true |