Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult liver size and metabolic liver zonation. The cellular origin of Wnt ligands respon...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2018-08, Vol.68 (2), p.707-722
Hauptverfasser:	Leibing, Thomas, Géraud, Cyrill, Augustin, Iris, Boutros, Michael, Augustin, Hellmut G., Okun, Jürgen G., Langhans, Claus‐Dieter, Zierow, Johanna, Wohlfeil, Sebastian A., Olsavszky, Victor, Schledzewski, Kai, Goerdt, Sergij, Koch, Philipp‐Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase Body weight Cholesterol Cytochrome P450 Endothelial cells Endothelial Cells - metabolism Fluorescent Antibody Technique Fusion protein Genotyping Techniques Glutamate-ammonia ligase Glutamine Heparan sulfate Hepatocytes Hepatocytes - metabolism Hepatology Homeostasis - physiology Immunohistochemistry In Situ Hybridization Lipid metabolism Lipid Metabolism - physiology Liver Liver - growth & development Liver - metabolism Maturation Metabolism Mice Mice, Knockout Original Real-Time Polymerase Chain Reaction Wnt protein Wnt Proteins - metabolism Wnt Signaling Pathway - genetics Zonation
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