Caveolin 3-dependent loss of t-tubular I Ca during hypertrophy and heart failure in mice

What is the central question of this study? Heart failure is associated with redistribution of L-type Ca current (I ) away from the t-tubule membrane to the surface membrane of cardiac ventricular myocytes. However, the underlying mechanism and its dependence on severity of pathology (hypertrophy ve...

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Veröffentlicht in:	Experimental physiology 2018-05, Vol.103 (5), p.652-665
Hauptverfasser:	Bryant, Simon M, Kong, Cherrie H T, Watson, Judy J, Gadeberg, Hanne C, James, Andrew F, Cannell, Mark B, Orchard, Clive H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, L-Type - metabolism Calcium Signaling - physiology Cardiomegaly - metabolism Cardiomegaly - physiopathology Caveolin 3 - metabolism Excitation Contraction Coupling - physiology Heart Failure - metabolism Heart Failure - physiopathology Heart Ventricles - metabolism Heart Ventricles - physiopathology Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Rats Research Paper Research Papers
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