KNDy Cells Revisited
Abstract In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified in the mammalian hypothalamus, a plethora of new research has emerged adding insights into the role of this neuronal population in reproductive neuroendocrine function, including the basis for GnRH...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2018-09, Vol.159 (9), p.3219-3234 |
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| creator | Moore, Aleisha M Coolen, Lique M Porter, Danielle T Goodman, Robert L Lehman, Michael N |
| description | Abstract
In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified in the mammalian hypothalamus, a plethora of new research has emerged adding insights into the role of this neuronal population in reproductive neuroendocrine function, including the basis for GnRH pulse generation and the mechanisms underlying the steroid feedback control of GnRH secretion. In this mini-review, we provide an update of evidence regarding the roles of KNDy peptides and their postsynaptic receptors in producing episodic GnRH release and assess the relative contribution of KNDy neurons to the “GnRH pulse generator.” In addition, we examine recent work investigating the role of KNDy neurons as mediators of steroid hormone negative feedback and review evidence for their involvement in the preovulatory GnRH/LH surge, taking into account species differences that exist among rodents, ruminants, and primates. Finally, we summarize emerging roles of KNDy neurons in other aspects of reproductive function and in nonreproductive functions and discuss critical unresolved questions in our understanding of KNDy neurobiology.
This review discusses key research from the last decade that has provided new insights into the control of mammalian reproduction by kisspeptin/neurokinin B/dynorphin (KNDy) neurons. |
| doi_str_mv | 10.1210/en.2018-00389 |
| format | Article |
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In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified in the mammalian hypothalamus, a plethora of new research has emerged adding insights into the role of this neuronal population in reproductive neuroendocrine function, including the basis for GnRH pulse generation and the mechanisms underlying the steroid feedback control of GnRH secretion. In this mini-review, we provide an update of evidence regarding the roles of KNDy peptides and their postsynaptic receptors in producing episodic GnRH release and assess the relative contribution of KNDy neurons to the “GnRH pulse generator.” In addition, we examine recent work investigating the role of KNDy neurons as mediators of steroid hormone negative feedback and review evidence for their involvement in the preovulatory GnRH/LH surge, taking into account species differences that exist among rodents, ruminants, and primates. Finally, we summarize emerging roles of KNDy neurons in other aspects of reproductive function and in nonreproductive functions and discuss critical unresolved questions in our understanding of KNDy neurobiology.
This review discusses key research from the last decade that has provided new insights into the control of mammalian reproduction by kisspeptin/neurokinin B/dynorphin (KNDy) neurons.</description><identifier>ISSN: 1945-7170</identifier><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2018-00389</identifier><identifier>PMID: 30010844</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Animals ; Dynorphin ; Dynorphins - metabolism ; Endocrinology ; Estrogens - metabolism ; Feedback ; Feedback control ; Female ; Gonadotropin-releasing hormone ; Gonadotropin-Releasing Hormone - metabolism ; Humans ; Hypothalamus ; Hypothalamus - cytology ; Hypothalamus - metabolism ; Hypothalamus - physiology ; Kiss1 protein ; Kisspeptins - metabolism ; Luteinizing hormone ; Menopause ; Mini-Reviews ; Negative feedback ; Nervous system ; Neurokinin ; Neurokinin B ; Neurokinin B - metabolism ; Neurons ; Neurons - metabolism ; Neurons - physiology ; Neurosciences ; Peptides ; Primates ; Progesterone - metabolism ; Pulse generators ; Receptors ; Reproduction - physiology ; Reviews ; Rodents ; Secretion ; Steroids ; Testosterone - metabolism</subject><ispartof>Endocrinology (Philadelphia), 2018-09, Vol.159 (9), p.3219-3234</ispartof><rights>Copyright © 2018 Endocrine Society 2018</rights><rights>Copyright © 2018 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-403c8fa3177c8220360bd997671c0e8dae9eeff709fc4484bb47cdc9735a68be3</citedby><cites>FETCH-LOGICAL-c448t-403c8fa3177c8220360bd997671c0e8dae9eeff709fc4484bb47cdc9735a68be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30010844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Aleisha M</creatorcontrib><creatorcontrib>Coolen, Lique M</creatorcontrib><creatorcontrib>Porter, Danielle T</creatorcontrib><creatorcontrib>Goodman, Robert L</creatorcontrib><creatorcontrib>Lehman, Michael N</creatorcontrib><title>KNDy Cells Revisited</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Abstract
In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified in the mammalian hypothalamus, a plethora of new research has emerged adding insights into the role of this neuronal population in reproductive neuroendocrine function, including the basis for GnRH pulse generation and the mechanisms underlying the steroid feedback control of GnRH secretion. In this mini-review, we provide an update of evidence regarding the roles of KNDy peptides and their postsynaptic receptors in producing episodic GnRH release and assess the relative contribution of KNDy neurons to the “GnRH pulse generator.” In addition, we examine recent work investigating the role of KNDy neurons as mediators of steroid hormone negative feedback and review evidence for their involvement in the preovulatory GnRH/LH surge, taking into account species differences that exist among rodents, ruminants, and primates. Finally, we summarize emerging roles of KNDy neurons in other aspects of reproductive function and in nonreproductive functions and discuss critical unresolved questions in our understanding of KNDy neurobiology.
This review discusses key research from the last decade that has provided new insights into the control of mammalian reproduction by kisspeptin/neurokinin B/dynorphin (KNDy) neurons.</description><subject>Animals</subject><subject>Dynorphin</subject><subject>Dynorphins - metabolism</subject><subject>Endocrinology</subject><subject>Estrogens - metabolism</subject><subject>Feedback</subject><subject>Feedback control</subject><subject>Female</subject><subject>Gonadotropin-releasing hormone</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Hypothalamus - cytology</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus - physiology</subject><subject>Kiss1 protein</subject><subject>Kisspeptins - metabolism</subject><subject>Luteinizing hormone</subject><subject>Menopause</subject><subject>Mini-Reviews</subject><subject>Negative feedback</subject><subject>Nervous system</subject><subject>Neurokinin</subject><subject>Neurokinin B</subject><subject>Neurokinin B - metabolism</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Neurons - physiology</subject><subject>Neurosciences</subject><subject>Peptides</subject><subject>Primates</subject><subject>Progesterone - metabolism</subject><subject>Pulse generators</subject><subject>Receptors</subject><subject>Reproduction - physiology</subject><subject>Reviews</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Steroids</subject><subject>Testosterone - metabolism</subject><issn>1945-7170</issn><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9LwzAQx4Mobk7f9FUGvvjSeWmyJnkRxvyJQ0H0OaTpVTu6djbtYP-9qZtzCj7lIN_73H2_R8gJhQENKVxgMQiBygCASbVDulTxYSCogN2tukMOnJsCUM452ycd5kuQnHfJ8cPj1bI_xjx3_WdcZC6rMTkke6nJHR6t3x55vbl-Gd8Fk6fb-_FoEljOZR1wYFamhlEhrAxDYBHEiVIiEtQCysSgQkxTASptG3gcc2ETqwQbmkjGyHrkcsWdN_EME4tFXZlcz6tsZqqlLk2mf_8U2bt-Kxc6AuUHDj3gfA2oyo8GXa1nmbPejCmwbJwOQYBQSrLIS8_-SKdlUxXeng6Zz44rwVtgsFLZqnSuwnSzDAXd5q2x0G3e-itvrz_ddrBRfwf8s2HZzP9jrW7HPgG_j4Uj</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Moore, Aleisha M</creator><creator>Coolen, Lique M</creator><creator>Porter, Danielle T</creator><creator>Goodman, Robert L</creator><creator>Lehman, Michael N</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>KNDy Cells Revisited</title><author>Moore, Aleisha M ; Coolen, Lique M ; Porter, Danielle T ; Goodman, Robert L ; Lehman, Michael N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-403c8fa3177c8220360bd997671c0e8dae9eeff709fc4484bb47cdc9735a68be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Dynorphin</topic><topic>Dynorphins - metabolism</topic><topic>Endocrinology</topic><topic>Estrogens - metabolism</topic><topic>Feedback</topic><topic>Feedback control</topic><topic>Female</topic><topic>Gonadotropin-releasing hormone</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Hypothalamus - cytology</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus - physiology</topic><topic>Kiss1 protein</topic><topic>Kisspeptins - metabolism</topic><topic>Luteinizing hormone</topic><topic>Menopause</topic><topic>Mini-Reviews</topic><topic>Negative feedback</topic><topic>Nervous system</topic><topic>Neurokinin</topic><topic>Neurokinin B</topic><topic>Neurokinin B - metabolism</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Neurons - physiology</topic><topic>Neurosciences</topic><topic>Peptides</topic><topic>Primates</topic><topic>Progesterone - metabolism</topic><topic>Pulse generators</topic><topic>Receptors</topic><topic>Reproduction - physiology</topic><topic>Reviews</topic><topic>Rodents</topic><topic>Secretion</topic><topic>Steroids</topic><topic>Testosterone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, Aleisha M</creatorcontrib><creatorcontrib>Coolen, Lique M</creatorcontrib><creatorcontrib>Porter, Danielle T</creatorcontrib><creatorcontrib>Goodman, Robert L</creatorcontrib><creatorcontrib>Lehman, Michael N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Aleisha M</au><au>Coolen, Lique M</au><au>Porter, Danielle T</au><au>Goodman, Robert L</au><au>Lehman, Michael N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KNDy Cells Revisited</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>159</volume><issue>9</issue><spage>3219</spage><epage>3234</epage><pages>3219-3234</pages><issn>1945-7170</issn><issn>0013-7227</issn><eissn>1945-7170</eissn><abstract>Abstract
In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified in the mammalian hypothalamus, a plethora of new research has emerged adding insights into the role of this neuronal population in reproductive neuroendocrine function, including the basis for GnRH pulse generation and the mechanisms underlying the steroid feedback control of GnRH secretion. In this mini-review, we provide an update of evidence regarding the roles of KNDy peptides and their postsynaptic receptors in producing episodic GnRH release and assess the relative contribution of KNDy neurons to the “GnRH pulse generator.” In addition, we examine recent work investigating the role of KNDy neurons as mediators of steroid hormone negative feedback and review evidence for their involvement in the preovulatory GnRH/LH surge, taking into account species differences that exist among rodents, ruminants, and primates. Finally, we summarize emerging roles of KNDy neurons in other aspects of reproductive function and in nonreproductive functions and discuss critical unresolved questions in our understanding of KNDy neurobiology.
This review discusses key research from the last decade that has provided new insights into the control of mammalian reproduction by kisspeptin/neurokinin B/dynorphin (KNDy) neurons.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><pmid>30010844</pmid><doi>10.1210/en.2018-00389</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1945-7170 0013-7227 1945-7170 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animals Dynorphin Dynorphins - metabolism Endocrinology Estrogens - metabolism Feedback Feedback control Female Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - metabolism Humans Hypothalamus Hypothalamus - cytology Hypothalamus - metabolism Hypothalamus - physiology Kiss1 protein Kisspeptins - metabolism Luteinizing hormone Menopause Mini-Reviews Negative feedback Nervous system Neurokinin Neurokinin B Neurokinin B - metabolism Neurons Neurons - metabolism Neurons - physiology Neurosciences Peptides Primates Progesterone - metabolism Pulse generators Receptors Reproduction - physiology Reviews Rodents Secretion Steroids Testosterone - metabolism |
| title | KNDy Cells Revisited |
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