A review of artifacts in histopathology

Histopathological examination is considered as gold standard procedure for arriving at a final diagnosis of various lesions of the human body. However, it is limited by a number of alterations of normal morphologic and cytological features that occur as a result of presence of artifacts. These artif...

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Veröffentlicht in:Journal of oral and maxillofacial pathology : JOMFP 2018-05, Vol.22 (2), p.279-279
Hauptverfasser: Taqi, Syed, Sami, Syed, Sami, Lateef, Zaki, Syed
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container_title Journal of oral and maxillofacial pathology : JOMFP
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creator Taqi, Syed
Sami, Syed
Sami, Lateef
Zaki, Syed
description Histopathological examination is considered as gold standard procedure for arriving at a final diagnosis of various lesions of the human body. However, it is limited by a number of alterations of normal morphologic and cytological features that occur as a result of presence of artifacts. These artifacts may occur during surgical removal, fixation, tissue processing, embedding and microtomy and staining and mounting procedures. They can even lead to complete uselessness of the tissue. It is therefore essential to identify the commonly occurring artifacts during histopathological interpretations of tissue sections. This article reviews the common artifacts encountered during slide examination alongside the remedial measures which can be undertaken to differentiate between an artifact and tissue constituent.
doi_str_mv 10.4103/jomfp.JOMFP_125_15
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subjects Acids
Aluminum
Bubbles
Cytoplasm
Embedding
Enzymes
Localization
Pathological histology
Pigments
Potassium
Review
title A review of artifacts in histopathology
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