p47phox-Dependent Reactive Oxygen Species Stimulate Nuclear Translocation of the FoxO1 Transcription Factor During Metabolic Inhibition in Cardiomyoblasts

Reactive oxygen species (ROS) control forkhead box O (FOXO) transcription factor activity by influencing their nuclear translocation. However, knowledge of the ROS cellular source(s) involved herein remains scarce. Recently, we have shown p47 phox -dependent activation of ROS-producing NADPH oxidase...

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Veröffentlicht in:	Cell biochemistry and biophysics 2018-09, Vol.76 (3), p.401-410
Hauptverfasser:	ter Horst, Ellis N., Hahn, Nynke E., Geerts, Dirk, Musters, René J. P., Paulus, Walter J., van Rossum, Albert C., Meischl, Christof, Piek, Jan J., Niessen, Hans W. M., Krijnen, Paul A. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Digital imaging Fluorescence Forkhead protein FOXO1 protein Ischemia Life Sciences Metabolism NAD(P)H oxidase Nitrotyrosine Nuclear transport Original Paper Pharmacology/Toxicology Protein transport Proteins Reactive oxygen species Ribonucleic acid RNA Small intestine Transcription factors Transfection Translocation
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