Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders
The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca 2+ -sensitive motor complex, facilit...
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| Veröffentlicht in: | Molecular neurobiology 2018-09, Vol.55 (9), p.7352-7365 |
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| creator | Kay, Laura Pienaar, Ilse S. Cooray, Ruwini Black, Gary Soundararajan, Meera |
| description | The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca
2+
-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegenerative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease. |
| doi_str_mv | 10.1007/s12035-018-0927-x |
| format | Article |
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2+
-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegenerative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-018-0927-x</identifier><identifier>PMID: 29411264</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alzheimer's disease ; Amyotrophic lateral sclerosis ; Animals ; Anterograde transport ; Axonal transport ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Cell Biology ; Dendrites ; Disease Models, Animal ; Dopamine receptors ; GTP Phosphohydrolases - chemistry ; GTP Phosphohydrolases - metabolism ; Hands ; Homeostasis ; Humans ; Insects ; Life sciences ; Mammals ; Medical treatment ; Mental disorders ; Microtubules ; Mitochondria ; Mitochondria - metabolism ; Mitochondrial Dynamics ; Molecular structure ; Morphology ; Neurobiology ; Neurodegenerative diseases ; Neurodegenerative Diseases - enzymology ; Neurodegenerative Diseases - therapy ; Neurology ; Neurosciences ; Parkinson's disease ; Proteins ; Retrograde transport</subject><ispartof>Molecular neurobiology, 2018-09, Vol.55 (9), p.7352-7365</ispartof><rights>The Author(s) 2018</rights><rights>Molecular Neurobiology is a copyright of Springer, (2018). All Rights Reserved. © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1809b30762e00d8973a90384a41928e84b4b4dd3601862395c9c578b40d96dbd3</citedby><cites>FETCH-LOGICAL-c470t-1809b30762e00d8973a90384a41928e84b4b4dd3601862395c9c578b40d96dbd3</cites><orcidid>0000-0003-4687-0151</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-018-0927-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-018-0927-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29411264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kay, Laura</creatorcontrib><creatorcontrib>Pienaar, Ilse S.</creatorcontrib><creatorcontrib>Cooray, Ruwini</creatorcontrib><creatorcontrib>Black, Gary</creatorcontrib><creatorcontrib>Soundararajan, Meera</creatorcontrib><title>Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. It is now well-established that these enzymes act as essential components of a Ca
2+
-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegenerative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.</description><subject>Alzheimer's disease</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Animals</subject><subject>Anterograde transport</subject><subject>Axonal transport</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Cell Biology</subject><subject>Dendrites</subject><subject>Disease Models, Animal</subject><subject>Dopamine receptors</subject><subject>GTP Phosphohydrolases - chemistry</subject><subject>GTP Phosphohydrolases - metabolism</subject><subject>Hands</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insects</subject><subject>Life sciences</subject><subject>Mammals</subject><subject>Medical treatment</subject><subject>Mental disorders</subject><subject>Microtubules</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondrial Dynamics</subject><subject>Molecular structure</subject><subject>Morphology</subject><subject>Neurobiology</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - 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chemistry</topic><topic>GTP Phosphohydrolases - metabolism</topic><topic>Hands</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insects</topic><topic>Life sciences</topic><topic>Mammals</topic><topic>Medical treatment</topic><topic>Mental disorders</topic><topic>Microtubules</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondrial Dynamics</topic><topic>Molecular structure</topic><topic>Morphology</topic><topic>Neurobiology</topic><topic>Neurodegenerative diseases</topic><topic>Neurodegenerative Diseases - enzymology</topic><topic>Neurodegenerative Diseases - therapy</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Parkinson's disease</topic><topic>Proteins</topic><topic>Retrograde transport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kay, Laura</creatorcontrib><creatorcontrib>Pienaar, Ilse S.</creatorcontrib><creatorcontrib>Cooray, Ruwini</creatorcontrib><creatorcontrib>Black, Gary</creatorcontrib><creatorcontrib>Soundararajan, Meera</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kay, Laura</au><au>Pienaar, Ilse S.</au><au>Cooray, Ruwini</au><au>Black, Gary</au><au>Soundararajan, Meera</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>55</volume><issue>9</issue><spage>7352</spage><epage>7365</epage><pages>7352-7365</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>The Miro GTPases represent an unusual subgroup of the Ras superfamily and have recently emerged as important mediators of mitochondrial dynamics and for maintaining neuronal health. 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2+
-sensitive motor complex, facilitating the transport of mitochondria along microtubules in several cell types, including dopaminergic neurons. The Miros appear to be critical for both anterograde and retrograde mitochondrial transport in axons and dendrites, both of which are considered essential for neuronal health. Furthermore, the Miros may be significantly involved in the development of several serious pathological processes, including the development of neurodegenerative and psychiatric disorders. In this review, we discuss the molecular structure and known mitochondrial functions of the Miro GTPases in humans and other organisms, in the context of neurodegenerative disease. Finally, we consider the potential human Miros hold as novel therapeutic targets for the treatment of such disease.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29411264</pmid><doi>10.1007/s12035-018-0927-x</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4687-0151</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular neurobiology, 2018-09, Vol.55 (9), p.7352-7365 |
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| subjects | Alzheimer's disease Amyotrophic lateral sclerosis Animals Anterograde transport Axonal transport Biomedical and Life Sciences Biomedicine Calcium Cell Biology Dendrites Disease Models, Animal Dopamine receptors GTP Phosphohydrolases - chemistry GTP Phosphohydrolases - metabolism Hands Homeostasis Humans Insects Life sciences Mammals Medical treatment Mental disorders Microtubules Mitochondria Mitochondria - metabolism Mitochondrial Dynamics Molecular structure Morphology Neurobiology Neurodegenerative diseases Neurodegenerative Diseases - enzymology Neurodegenerative Diseases - therapy Neurology Neurosciences Parkinson's disease Proteins Retrograde transport |
| title | Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders |
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