TR34/L98H Mutation in CYP51A Gene in Aspergillus fumigatus Clinical Isolates During Posaconazole Prophylaxis: First Case in Korea

Azole resistance in Aspergillus fumigatus is an emerging problem, especially in immunocompromised patients. It has been reported worldwide, including in Asia, but has not yet been reported in Korea. Here, we report a case of invasive pulmonary aspergillosis (IPA) caused by azole-resistant A. fumigat...

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Veröffentlicht in:	Mycopathologia (1975) 2018-08, Vol.183 (4), p.731-736
Hauptverfasser:	Lee, Hyeon-Jeong, Cho, Sung-Yeon, Lee, Dong-Gun, Park, Chulmin, Chun, Hye-Sun, Park, Yeon-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antifungal agents Antifungal Agents - administration & dosage Aspergillosis Aspergillus fumigatus Aspergillus fumigatus - genetics Aspergillus fumigatus - isolation & purification Bacteremia Biomedical and Life Sciences Bronchoalveolar Lavage Fluid - microbiology Carbapenemase Case reports Chemoprevention Clinical isolates Cytochrome P-450 Enzyme System - genetics Drug Resistance, Fungal Epidemiology Eukaryotic Microbiology Fungal Proteins - genetics Genes Genetic aspects Health maintenance organizations Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Immunocompromised Host Immunocompromised hosts Immunosuppressive agents Immunotherapy Invasive Pulmonary Aspergillosis - microbiology Itraconazole Klebsiella Life Sciences Male Medical Microbiology Medical schools Microbial Ecology Microbiology Municipalities Mutation Mutation, Missense Mycoses Patients Plant Sciences Pneumonia Posaconazole Prophylaxis Republic of Korea Short Communication Stem cell transplantation Transplantation Triazoles - administration & dosage Voriconazole Yard waste
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