A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma

A 68-year-old woman with liver dysfunction was diagnosed with nonalcoholic steatohepatitis (NASH) stage 1. Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same tim...

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Veröffentlicht in:Internal Medicine 2018/07/15, Vol.57(14), pp.2013-2018
Hauptverfasser: Akashi, Momoko, Tajiri, Kazuto, Wada, Akinori, Tsuneyama, Koichi, Kawai, Kengo, Yasumura, Satoshi, Minemura, Masami, Takahara, Terumi, Sugiyama, Toshiro
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container_end_page 2018
container_issue 14
container_start_page 2013
container_title Internal Medicine
container_volume 57
creator Akashi, Momoko
Tajiri, Kazuto
Wada, Akinori
Tsuneyama, Koichi
Kawai, Kengo
Yasumura, Satoshi
Minemura, Masami
Takahara, Terumi
Sugiyama, Toshiro
description A 68-year-old woman with liver dysfunction was diagnosed with nonalcoholic steatohepatitis (NASH) stage 1. Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same time, she was diagnosed with multiple myeloma (MM). In this case, the plasma levels of osteopontin (OPN), a proinflammatory cytokine that promotes liver fibrosis progression through the hedgehog pathway and is increased in patients with MM, were increased. This increased OPN expression was accompanied by the upregulation of the hedgehog pathway in this patient, suggesting that the MM-associated increase in OPN had promoted the progression of liver fibrosis through the hedgehog pathway. The progression of liver fibrosis should be monitored in patients with NASH if other diseases, such as MM, are present.
doi_str_mv 10.2169/internalmedicine.0092-17
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Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same time, she was diagnosed with multiple myeloma (MM). In this case, the plasma levels of osteopontin (OPN), a proinflammatory cytokine that promotes liver fibrosis progression through the hedgehog pathway and is increased in patients with MM, were increased. This increased OPN expression was accompanied by the upregulation of the hedgehog pathway in this patient, suggesting that the MM-associated increase in OPN had promoted the progression of liver fibrosis through the hedgehog pathway. 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Med.</addtitle><description>A 68-year-old woman with liver dysfunction was diagnosed with nonalcoholic steatohepatitis (NASH) stage 1. Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same time, she was diagnosed with multiple myeloma (MM). In this case, the plasma levels of osteopontin (OPN), a proinflammatory cytokine that promotes liver fibrosis progression through the hedgehog pathway and is increased in patients with MM, were increased. This increased OPN expression was accompanied by the upregulation of the hedgehog pathway in this patient, suggesting that the MM-associated increase in OPN had promoted the progression of liver fibrosis through the hedgehog pathway. 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subjects Aged
Ascites
Asian Continental Ancestry Group
Bile
Biopsy
Case Report
Cirrhosis
Female
Fibrosis
hedgehog pathway
Hedgehog Proteins - blood
Humans
Inflammation
Internal medicine
Jaundice
Liver
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - physiopathology
Liver diseases
Multiple myeloma
Multiple Myeloma - etiology
Multiple Myeloma - physiopathology
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - physiopathology
non-alcoholic steatohepatitis
Osteopontin
Plasma levels
title A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma
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