Anti-PD-1 monotherapy versus anti-PD1 plus anti-CTLA4 in advanced melanoma: how do we decide?

While salvage ipilimumab can induce responses comparable to use in first-line setting for those who have failed prior anti-PD-1 therapy (9), elevated serum lactate dehydrogenase (LDH) has been shown to be an incremental and independent negative prognostic marker for therapy response rate to ipilimum...

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