Releasable and traceless PEGylation of arginine-rich antimicrobial peptides† †Electronic supplementary information (ESI) available: Experimental procedures, synthesis and characterization of rPEGylation reagents and peptide–PEG conjugates, kinetic studies of PEGylation and dePEGylation (HPLC) and controls are included. See DOI: 10.1039/c7sc00770a

This study reports a strategy to temporarily mask arginine residues within antimicrobial peptides (AMPs) with methoxy poly(ethylene glycol) (mPEG). PEGylation protects AMPs from serum proteases, and can be released at a pharmaceutically-relevant rate. Fully active and unmodified ( i.e. , native) AMP...

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Veröffentlicht in:	Chemical science (Cambridge) 2017-03, Vol.8 (5), p.4082-4086
Hauptverfasser:	Gong, Y., Andina, D., Nahar, S., Leroux, J.-C., Gauthier, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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