Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR

Farnesoid X receptor (FXR) is a member of the family of ligand-activated nuclear receptors. FXR plays critical roles in maintaining many metabolic pathways, including bile acid regulation and glucose and lipid homeostasis, and forms a heterodimeric complex with the retinoid X receptor (RXR). Despite...

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Veröffentlicht in:	The Journal of biological chemistry 2018-08, Vol.293 (32), p.12535-12541
Hauptverfasser:	Zheng, Weili, Lu, Yi, Tian, Siyu, Ma, Fengge, Wei, Yijuan, Xu, Shuangshuang, Li, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Crystallography, X-Ray dimerization drug discovery FXR RXR heterodimer HEK293 Cells Humans nuclear receptor Protein Binding Protein Conformation Protein Multimerization Protein Structure and Folding receptor structure-function Retinoid X Receptors - chemistry Retinoid X Receptors - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism structural biology structural model transcriptional coactivator translation regulation X-ray crystallography
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