Mesenchymal Stem Cell Microvesicles Restore Protein Permeability Across Primary Cultures of Injured Human Lung Microvascular Endothelial Cells

Our previous study demonstrated that mesenchymal stem cell (MSC) microvesicles (MV) reduced lung inflammation, protein permeability, and pulmonary edema in endotoxin‐induced acute lung injury in mice. However, the underlying mechanisms for restoring lung protein permeability were not fully understoo...

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Veröffentlicht in:	Stem cells translational medicine 2018-08, Vol.7 (8), p.615-624
Hauptverfasser:	Hu, Shuling, Park, Jeonghyun, Liu, Airan, Lee, JaeHoon, Zhang, Xiwen, Hao, Qi, Lee, Jae‐Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Angiopoietin Angiopoietin-1 - antagonists & inhibitors Angiopoietin-1 - genetics Angiopoietin-1 - metabolism Antibodies - immunology Antibodies - pharmacology Antigens, CD - metabolism Bone marrow Cadherins Cadherins - metabolism CD44 antigen Cell Based Drug Development, Screening, and Toxicology Cells, Cultured Coculture Techniques Cytokines - pharmacology Cytoskeleton Dextran Edema Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Experiments Extracellular Vesicles - metabolism Fibroblasts Growth factors Human lung microvascular endothelial cell Humans Hyaluronan Receptors - immunology Inflammation / Inflammatory Disease Interferon Internalization Lung - cytology Lung protein permeability Lungs Mesenchymal stem cell Mesenchymal Stem Cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Microscopy Microscopy, Fluorescence Microvasculature Microvesicles Microvessels - cytology mRNA Penicillin Permeability Protein Transport - drug effects Proteins RNA Interference RNA, Small Interfering - metabolism Sediments siRNA Stem cell transplantation Stem cells Translational s and Reviews Tumor necrosis factor Zonula Occludens-1 Protein - metabolism
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