In vitro screening of cytotoxic activity of euphol from Euphorbia tirucalli on a large panel of human cancer-derived cell lines
A large number of classic antineoplastic agents are derived from plants. L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumo...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2018-08, Vol.16 (2), p.557-566 |
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| creator | Silva, Viviane Aline Oliveira Rosa, Marcela Nunes Tansini, Aline Oliveira, Renato J S Martinho, Olga Lima, João Paulo Pianowski, Luiz F Reis, Rui M |
| description | A large number of classic antineoplastic agents are derived from plants.
L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of
in a panel of 73 human cancer lines from 15 tumor types. The biological effect of euphol in pancreatic cells was also assessed. The combination index was further used to explore euphol interactions with standard drugs. Euphol showed a cytotoxicity effect against several cancer cell lines (IC
range, 1.41-38.89 µM), particularly in esophageal squamous cell (11.08 µM) and pancreatic carcinoma cells (6.84 µM), followed by prostate, melanoma, and colon cancer. Cytotoxicity effects were seen in all cancer cell lines, with more than half deemed highly sensitive. Euphol inhibited proliferation, motility and colony formation in pancreatic cancer cells. Importantly, euphol exhibited synergistic interactions with gemcitabine and paclitaxel in pancreatic and esophageal cell lines, respectively. To the best of our knowledge, this study constitutes the largest
screening of euphol efficacy on cancer cell lines and revealed its
anti-cancer properties, particularly in pancreatic and esophageal cell lines, suggesting that euphol, either as a single agent or in combination with conventional chemotherapy, is a potential anti-cancer drug. |
| doi_str_mv | 10.3892/etm.2018.6244 |
| format | Article |
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L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of
in a panel of 73 human cancer lines from 15 tumor types. The biological effect of euphol in pancreatic cells was also assessed. The combination index was further used to explore euphol interactions with standard drugs. Euphol showed a cytotoxicity effect against several cancer cell lines (IC
range, 1.41-38.89 µM), particularly in esophageal squamous cell (11.08 µM) and pancreatic carcinoma cells (6.84 µM), followed by prostate, melanoma, and colon cancer. Cytotoxicity effects were seen in all cancer cell lines, with more than half deemed highly sensitive. Euphol inhibited proliferation, motility and colony formation in pancreatic cancer cells. Importantly, euphol exhibited synergistic interactions with gemcitabine and paclitaxel in pancreatic and esophageal cell lines, respectively. To the best of our knowledge, this study constitutes the largest
screening of euphol efficacy on cancer cell lines and revealed its
anti-cancer properties, particularly in pancreatic and esophageal cell lines, suggesting that euphol, either as a single agent or in combination with conventional chemotherapy, is a potential anti-cancer drug.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.6244</identifier><identifier>PMID: 30112023</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Analysis ; Cancer therapies ; Cancer treatment ; Cell lines ; Esophageal cancer ; Health aspects ; Magnoliopsida ; Medical screening ; Oncology ; Pancreatic cancer ; Plant extracts ; Properties ; Standard deviation ; Studies</subject><ispartof>Experimental and therapeutic medicine, 2018-08, Vol.16 (2), p.557-566</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Silva et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-180201d2e9f4897c68f9336d1d7545b3a6489e5766949b0dd84e4f490c0515da3</citedby><cites>FETCH-LOGICAL-c507t-180201d2e9f4897c68f9336d1d7545b3a6489e5766949b0dd84e4f490c0515da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090420/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090420/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30112023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Viviane Aline Oliveira</creatorcontrib><creatorcontrib>Rosa, Marcela Nunes</creatorcontrib><creatorcontrib>Tansini, Aline</creatorcontrib><creatorcontrib>Oliveira, Renato J S</creatorcontrib><creatorcontrib>Martinho, Olga</creatorcontrib><creatorcontrib>Lima, João Paulo</creatorcontrib><creatorcontrib>Pianowski, Luiz F</creatorcontrib><creatorcontrib>Reis, Rui M</creatorcontrib><title>In vitro screening of cytotoxic activity of euphol from Euphorbia tirucalli on a large panel of human cancer-derived cell lines</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>A large number of classic antineoplastic agents are derived from plants.
L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of
in a panel of 73 human cancer lines from 15 tumor types. The biological effect of euphol in pancreatic cells was also assessed. The combination index was further used to explore euphol interactions with standard drugs. Euphol showed a cytotoxicity effect against several cancer cell lines (IC
range, 1.41-38.89 µM), particularly in esophageal squamous cell (11.08 µM) and pancreatic carcinoma cells (6.84 µM), followed by prostate, melanoma, and colon cancer. Cytotoxicity effects were seen in all cancer cell lines, with more than half deemed highly sensitive. Euphol inhibited proliferation, motility and colony formation in pancreatic cancer cells. Importantly, euphol exhibited synergistic interactions with gemcitabine and paclitaxel in pancreatic and esophageal cell lines, respectively. To the best of our knowledge, this study constitutes the largest
screening of euphol efficacy on cancer cell lines and revealed its
anti-cancer properties, particularly in pancreatic and esophageal cell lines, suggesting that euphol, either as a single agent or in combination with conventional chemotherapy, is a potential anti-cancer drug.</description><subject>Analysis</subject><subject>Cancer therapies</subject><subject>Cancer treatment</subject><subject>Cell lines</subject><subject>Esophageal cancer</subject><subject>Health aspects</subject><subject>Magnoliopsida</subject><subject>Medical screening</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Plant extracts</subject><subject>Properties</subject><subject>Standard deviation</subject><subject>Studies</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptksFvFCEUxidG0zZtj70aEi9eZgVmYOBi0jRVmzTxUs-EhTe7NAyswGzck_-6TLpWa4QDL4_fe-TjfU1zRfCqE5J-gDKtKCZixWnfv2rOyCBpSzBhr48xloKcNpc5P-K6GCdCsJPmtMOEUEy7s-bnXUB7V1JE2SSA4MIGxRGZQ4kl_nAGaVNcBQ5LFubdNno0pjih2yVOa6dRcWk22nuHYkAaeZ02gHY6gF9qtvOkAzI6GEitheT2YJEB75F3AfJF82bUPsPl8Txvvn26fbj50t5__Xx3c33fGoaH0hKBq05LQY69kIPhYpRdxy2xA-vZutO8poENnMterrG1ood-7CU2mBFmdXfefHzqu5vXE1gDoSTt1S65SaeDitqplzfBbdUm7hXHEvcU1wbvjw1S_D5DLmpyedFRhcY5K4rrQAYsKa3ou3_QxzinUOVVSnIq6lSGP9RGe1AujLG-a5am6poxKrkUmFVq9R-qbguTMzHA6Gr-RUH7VGBSzDnB-KyRYLWYRlXTqMU0ajFN5d_-_THP9G-LdL8ADu68hA</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Silva, Viviane Aline Oliveira</creator><creator>Rosa, Marcela Nunes</creator><creator>Tansini, Aline</creator><creator>Oliveira, Renato J S</creator><creator>Martinho, Olga</creator><creator>Lima, João Paulo</creator><creator>Pianowski, Luiz F</creator><creator>Reis, Rui M</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of
in a panel of 73 human cancer lines from 15 tumor types. The biological effect of euphol in pancreatic cells was also assessed. The combination index was further used to explore euphol interactions with standard drugs. Euphol showed a cytotoxicity effect against several cancer cell lines (IC
range, 1.41-38.89 µM), particularly in esophageal squamous cell (11.08 µM) and pancreatic carcinoma cells (6.84 µM), followed by prostate, melanoma, and colon cancer. Cytotoxicity effects were seen in all cancer cell lines, with more than half deemed highly sensitive. Euphol inhibited proliferation, motility and colony formation in pancreatic cancer cells. Importantly, euphol exhibited synergistic interactions with gemcitabine and paclitaxel in pancreatic and esophageal cell lines, respectively. To the best of our knowledge, this study constitutes the largest
screening of euphol efficacy on cancer cell lines and revealed its
anti-cancer properties, particularly in pancreatic and esophageal cell lines, suggesting that euphol, either as a single agent or in combination with conventional chemotherapy, is a potential anti-cancer drug.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30112023</pmid><doi>10.3892/etm.2018.6244</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental and therapeutic medicine, 2018-08, Vol.16 (2), p.557-566 |
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| subjects | Analysis Cancer therapies Cancer treatment Cell lines Esophageal cancer Health aspects Magnoliopsida Medical screening Oncology Pancreatic cancer Plant extracts Properties Standard deviation Studies |
| title | In vitro screening of cytotoxic activity of euphol from Euphorbia tirucalli on a large panel of human cancer-derived cell lines |
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