IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis
We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzhe...
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| Veröffentlicht in: | Scientific reports 2018-08, Vol.8 (1), p.12050-12, Article 12050 |
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| description | We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer’s disease. We searched Pubmed, PsycINFO and Embase, and thirty-four relevant studies (2609 with Depression, 1645 with Alzheimer’s disease and 14363 Controls) were included. Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078–1.206; significant heterogeneity: I
2
= 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156–0.598; significant heterogeneity: I
2
= 88.75%) were significantly elevated in depression. There was no difference in TNF-α (p = 0.351) and CRP (p = 0.05) between those with depression and controls. Compared with controls, IL-1β (pooled SMD: 1.37, 95% CI: 0.06–2.68, significant heterogeneity: I
2
= 96.01%) was significantly elevated in Alzheimer’s disease. There were no differences in IL-6 (p = 0.138), TNF-α (p = 0.451) and CRP (p = 0.07) between elderly with Alzheimer’s disease and controls. After Bonferroni adjustment, only IL-6 remained significantly higher in depression. Elderly with depression have higher IL-6 than controls, while those with Alzheimer’s disease did not have higher peripheral inflammatory markers. |
| doi_str_mv | 10.1038/s41598-018-30487-6 |
| format | Article |
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2
= 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156–0.598; significant heterogeneity: I
2
= 88.75%) were significantly elevated in depression. There was no difference in TNF-α (p = 0.351) and CRP (p = 0.05) between those with depression and controls. Compared with controls, IL-1β (pooled SMD: 1.37, 95% CI: 0.06–2.68, significant heterogeneity: I
2
= 96.01%) was significantly elevated in Alzheimer’s disease. There were no differences in IL-6 (p = 0.138), TNF-α (p = 0.451) and CRP (p = 0.07) between elderly with Alzheimer’s disease and controls. After Bonferroni adjustment, only IL-6 remained significantly higher in depression. Elderly with depression have higher IL-6 than controls, while those with Alzheimer’s disease did not have higher peripheral inflammatory markers.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-30487-6</identifier><identifier>PMID: 30104698</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/21 ; 692/53/2423 ; 692/699/476/1414 ; Adaptor Proteins, Signal Transducing ; Aged ; Alzheimer Disease - blood ; C-reactive protein ; C-Reactive Protein - analysis ; Cytokines ; Depression ; Depressive Disorder - blood ; Geriatrics ; Humanities and Social Sciences ; Humans ; Inflammation ; Inflammation - blood ; Interleukin 1 ; Interleukin 6 ; Interleukin-1beta - blood ; Interleukin-6 - blood ; Mental depression ; Meta-analysis ; Middle Aged ; multidisciplinary ; Proteins - analysis ; Science ; Science (multidisciplinary) ; Systematic review ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Scientific reports, 2018-08, Vol.8 (1), p.12050-12, Article 12050</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ed7098eef0ab07174a1d9e5e9ade9d6a2b865dd422e8b22efb211c7c11ba88383</citedby><cites>FETCH-LOGICAL-c474t-ed7098eef0ab07174a1d9e5e9ade9d6a2b865dd422e8b22efb211c7c11ba88383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089986/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089986/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30104698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Ada</creatorcontrib><creatorcontrib>Tam, Wilson W.</creatorcontrib><creatorcontrib>Zhang, Melvyn W.</creatorcontrib><creatorcontrib>Ho, Cyrus S.</creatorcontrib><creatorcontrib>Husain, Syeda F.</creatorcontrib><creatorcontrib>McIntyre, Roger S.</creatorcontrib><creatorcontrib>Ho, Roger C.</creatorcontrib><title>IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer’s disease. We searched Pubmed, PsycINFO and Embase, and thirty-four relevant studies (2609 with Depression, 1645 with Alzheimer’s disease and 14363 Controls) were included. Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078–1.206; significant heterogeneity: I
2
= 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156–0.598; significant heterogeneity: I
2
= 88.75%) were significantly elevated in depression. There was no difference in TNF-α (p = 0.351) and CRP (p = 0.05) between those with depression and controls. Compared with controls, IL-1β (pooled SMD: 1.37, 95% CI: 0.06–2.68, significant heterogeneity: I
2
= 96.01%) was significantly elevated in Alzheimer’s disease. There were no differences in IL-6 (p = 0.138), TNF-α (p = 0.451) and CRP (p = 0.07) between elderly with Alzheimer’s disease and controls. After Bonferroni adjustment, only IL-6 remained significantly higher in depression. Elderly with depression have higher IL-6 than controls, while those with Alzheimer’s disease did not have higher peripheral inflammatory markers.</description><subject>13/21</subject><subject>692/53/2423</subject><subject>692/699/476/1414</subject><subject>Adaptor Proteins, Signal Transducing</subject><subject>Aged</subject><subject>Alzheimer Disease - blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cytokines</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Geriatrics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-6 - blood</subject><subject>Mental depression</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Proteins - analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Systematic review</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFOGzEQhi1EBYjyAj1Ulrji1vZ6d-0ekKIUKFLaIkrPlnc9IUab3eDZgMIFXqOP0T4ID9EnqUMohUt98Fia___Ho4-QN4K_EzzT71GJ3GjGhWYZV7pkxRrZklzlTGZSrj97b5IdxAueTi6NEmaDbGZccFUYvUVuj0dM3P_ao6kWe_TsyyGj9z-paz0dnp7Q0NKDxkNsFvTE9QHaHul16Cf0I8wiIIaupV2kg-ZmAmEK8ffdD6Q-IDiED_TbAnuYJl9NT-EqwPVD7mfoHRu0rllgwNfk1dg1CDuPdZt8Pzw4G35io69Hx8PBiNWqVD0DX3KjAcbcVbwUpXLCG8jBOA_GF05Wusi9V1KCrtI1rqQQdVkLUTmtM51tk_1V7mxeTcHXaZPoGjuLYeriwnYu2JedNkzseXdlC66N0UUK2H0MiN3lHLC3F908pi3QSq51QiLNUiVXqjp2iBHGTxMEt0tudsXNJm72gZtdmt4-_9uT5S-lJMhWAkyt9hziv9n_if0DCuulrw</recordid><startdate>20180813</startdate><enddate>20180813</enddate><creator>Ng, Ada</creator><creator>Tam, Wilson W.</creator><creator>Zhang, Melvyn W.</creator><creator>Ho, Cyrus S.</creator><creator>Husain, Syeda F.</creator><creator>McIntyre, Roger S.</creator><creator>Ho, Roger C.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20180813</creationdate><title>IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis</title><author>Ng, Ada ; Tam, Wilson W. ; Zhang, Melvyn W. ; Ho, Cyrus S. ; Husain, Syeda F. ; McIntyre, Roger S. ; Ho, Roger C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ed7098eef0ab07174a1d9e5e9ade9d6a2b865dd422e8b22efb211c7c11ba88383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/21</topic><topic>692/53/2423</topic><topic>692/699/476/1414</topic><topic>Adaptor Proteins, Signal Transducing</topic><topic>Aged</topic><topic>Alzheimer Disease - blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cytokines</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Geriatrics</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Interleukin 1</topic><topic>Interleukin 6</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-6 - blood</topic><topic>Mental depression</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Proteins - analysis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Systematic review</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Ada</creatorcontrib><creatorcontrib>Tam, Wilson W.</creatorcontrib><creatorcontrib>Zhang, Melvyn W.</creatorcontrib><creatorcontrib>Ho, Cyrus S.</creatorcontrib><creatorcontrib>Husain, Syeda F.</creatorcontrib><creatorcontrib>McIntyre, Roger S.</creatorcontrib><creatorcontrib>Ho, Roger C.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Ada</au><au>Tam, Wilson W.</au><au>Zhang, Melvyn W.</au><au>Ho, Cyrus S.</au><au>Husain, Syeda F.</au><au>McIntyre, Roger S.</au><au>Ho, Roger C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-08-13</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>12050</spage><epage>12</epage><pages>12050-12</pages><artnum>12050</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer’s disease. We searched Pubmed, PsycINFO and Embase, and thirty-four relevant studies (2609 with Depression, 1645 with Alzheimer’s disease and 14363 Controls) were included. Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078–1.206; significant heterogeneity: I
2
= 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156–0.598; significant heterogeneity: I
2
= 88.75%) were significantly elevated in depression. There was no difference in TNF-α (p = 0.351) and CRP (p = 0.05) between those with depression and controls. Compared with controls, IL-1β (pooled SMD: 1.37, 95% CI: 0.06–2.68, significant heterogeneity: I
2
= 96.01%) was significantly elevated in Alzheimer’s disease. There were no differences in IL-6 (p = 0.138), TNF-α (p = 0.451) and CRP (p = 0.07) between elderly with Alzheimer’s disease and controls. After Bonferroni adjustment, only IL-6 remained significantly higher in depression. Elderly with depression have higher IL-6 than controls, while those with Alzheimer’s disease did not have higher peripheral inflammatory markers.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30104698</pmid><doi>10.1038/s41598-018-30487-6</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/21 692/53/2423 692/699/476/1414 Adaptor Proteins, Signal Transducing Aged Alzheimer Disease - blood C-reactive protein C-Reactive Protein - analysis Cytokines Depression Depressive Disorder - blood Geriatrics Humanities and Social Sciences Humans Inflammation Inflammation - blood Interleukin 1 Interleukin 6 Interleukin-1beta - blood Interleukin-6 - blood Mental depression Meta-analysis Middle Aged multidisciplinary Proteins - analysis Science Science (multidisciplinary) Systematic review Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis |
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