IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3- and p38 MAPK-mediated signals

Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons...

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Veröffentlicht in:	International journal of molecular medicine 2018-06, Vol.42 (3), p.1484-1494
Hauptverfasser:	Ohta, Maiko, Chosa, Naoyuki, Kyakumoto, Seiko, Yokota, Seiji, Okubo, Naoto, Nemoto, Akira, Kamo, Masaharu, Joh, Shigeharu, Satoh, Kenichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines Fibroblasts Growth factors Kinases Neurons Proteins Rodents Signal transduction Trauma Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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