Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C
Purpose To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC). Methods A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old, n = 85) and group 2 ( > 60 years old, n = 58...
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| Veröffentlicht in: | Eye (London) 2018-08, Vol.32 (8), p.1321-1328 |
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| creator | Hoang, Thi Kieu Hau Kim, Young Kook Jeoung, Jin Wook Park, Ki Ho |
| description | Purpose
To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC).
Methods
A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old,
n
= 85) and group 2 ( > 60 years old,
n
= 58). Kaplan–Meier survival curve analysis was used to assess long-term surgical success according to “complete success” (intraocular pressure (IOP) reduction ≥ 30% without medications) and “qualified success” criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months.
Results
The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (
p
|
| doi_str_mv | 10.1038/s41433-018-0071-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6085316</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2019043200</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-a312763eeb6465fd462288ae11a61a56826277e68d50c99cdab78c4d9864688b3</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVJabZpf0AuQZBLL25HsiTLl0JZ-gWBQmkgpwpZnt3VYstbSc7Hv6-WTdM2kNOIeZ95NcNLyCmDtwxq_S4JJuq6AqYrgIZVt8_IgolGVVJIcUQW0EqoOOdXx-RlSluAIjbwghzzVmomOV-Qn99xsNlPIW38jnaYbxADtWukNvQ0zXHtnR3KwzlMidpVxkhztB26eUCXp_GO3vi8obbfzsFlf4109Pu284EuX5HnKzskfH1fT8jlp48_ll-qi2-fvy4_XFRONJArWzPeqBqxU0LJVS8U51pbZMwqZqXSXPGmQaV7Ca5tXW-7RjvRt7rwWnf1CXl_8N3N3Yi9w1B2HMwu-tHGOzNZb_5Xgt-Y9XRtFGhZM1UM3twbxOnXjCmb0SeHw2ADTnMyHFgLouYABT1_hG6nOYZyXqG04kK2am_IDpSLU0oRVw_LMDD79MwhPVPSM_v0zG2ZOfv3ioeJP3EVgB-AVKSwxvj366ddfwNwkacO</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2086245966</pqid></control><display><type>article</type><title>Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Hoang, Thi Kieu Hau ; Kim, Young Kook ; Jeoung, Jin Wook ; Park, Ki Ho</creator><creatorcontrib>Hoang, Thi Kieu Hau ; Kim, Young Kook ; Jeoung, Jin Wook ; Park, Ki Ho</creatorcontrib><description>Purpose
To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC).
Methods
A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old,
n
= 85) and group 2 ( > 60 years old,
n
= 58). Kaplan–Meier survival curve analysis was used to assess long-term surgical success according to “complete success” (intraocular pressure (IOP) reduction ≥ 30% without medications) and “qualified success” criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months.
Results
The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (
p
< 0.001 and
p
= 0.01, respectively). Age and preoperative anti-glaucoma medications were the factors related to complete success (
p
= 0.001). Also, there were significant differences in height, extent and vascularity of bleb between the two groups (
p
= 0.038,
p
= 0.002 and
p
= 0.006, respectively).
Conclusion
The long-term surgical outcome after trabeculectomy with MMC was better in the younger-age group than in the older-age group. Specifically, the younger-age group showed a more prominent and more localized bleb with less vascularity.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-018-0071-x</identifier><identifier>PMID: 29581522</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/3161/3169/3170 ; 692/700/1750 ; Administration, Topical ; Adolescent ; Adult ; Age Distribution ; Age Factors ; Age groups ; Aged ; Alkylating Agents - administration & dosage ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Glaucoma ; Glaucoma, Open-Angle - physiopathology ; Glaucoma, Open-Angle - surgery ; Humans ; Incidence ; Intraocular Pressure - physiology ; Intraoperative Period ; Laboratory Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mitomycin - administration & dosage ; Mitomycin C ; Morphology ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Postoperative Complications - epidemiology ; Postoperative Complications - prevention & control ; Republic of Korea - epidemiology ; Retrospective Studies ; Success ; Surgery ; Surgical Oncology ; Time Factors ; Trabeculectomy - methods ; Treatment Outcome ; Visual Acuity ; Young Adult</subject><ispartof>Eye (London), 2018-08, Vol.32 (8), p.1321-1328</ispartof><rights>The Royal College of Ophthalmologists 2018</rights><rights>Copyright Nature Publishing Group Aug 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-a312763eeb6465fd462288ae11a61a56826277e68d50c99cdab78c4d9864688b3</citedby><cites>FETCH-LOGICAL-c470t-a312763eeb6465fd462288ae11a61a56826277e68d50c99cdab78c4d9864688b3</cites><orcidid>0000-0002-8137-8843</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085316/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085316/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,41475,42544,51306,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29581522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoang, Thi Kieu Hau</creatorcontrib><creatorcontrib>Kim, Young Kook</creatorcontrib><creatorcontrib>Jeoung, Jin Wook</creatorcontrib><creatorcontrib>Park, Ki Ho</creatorcontrib><title>Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC).
Methods
A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old,
n
= 85) and group 2 ( > 60 years old,
n
= 58). Kaplan–Meier survival curve analysis was used to assess long-term surgical success according to “complete success” (intraocular pressure (IOP) reduction ≥ 30% without medications) and “qualified success” criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months.
Results
The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (
p
< 0.001 and
p
= 0.01, respectively). Age and preoperative anti-glaucoma medications were the factors related to complete success (
p
= 0.001). Also, there were significant differences in height, extent and vascularity of bleb between the two groups (
p
= 0.038,
p
= 0.002 and
p
= 0.006, respectively).
Conclusion
The long-term surgical outcome after trabeculectomy with MMC was better in the younger-age group than in the older-age group. Specifically, the younger-age group showed a more prominent and more localized bleb with less vascularity.</description><subject>692/499</subject><subject>692/699/3161/3169/3170</subject><subject>692/700/1750</subject><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Age groups</subject><subject>Aged</subject><subject>Alkylating Agents - administration & dosage</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Glaucoma, Open-Angle - surgery</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intraocular Pressure - physiology</subject><subject>Intraoperative Period</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mitomycin - administration & dosage</subject><subject>Mitomycin C</subject><subject>Morphology</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Success</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Time Factors</subject><subject>Trabeculectomy - methods</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><subject>Young Adult</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1r3DAQhkVJabZpf0AuQZBLL25HsiTLl0JZ-gWBQmkgpwpZnt3VYstbSc7Hv6-WTdM2kNOIeZ95NcNLyCmDtwxq_S4JJuq6AqYrgIZVt8_IgolGVVJIcUQW0EqoOOdXx-RlSluAIjbwghzzVmomOV-Qn99xsNlPIW38jnaYbxADtWukNvQ0zXHtnR3KwzlMidpVxkhztB26eUCXp_GO3vi8obbfzsFlf4109Pu284EuX5HnKzskfH1fT8jlp48_ll-qi2-fvy4_XFRONJArWzPeqBqxU0LJVS8U51pbZMwqZqXSXPGmQaV7Ca5tXW-7RjvRt7rwWnf1CXl_8N3N3Yi9w1B2HMwu-tHGOzNZb_5Xgt-Y9XRtFGhZM1UM3twbxOnXjCmb0SeHw2ADTnMyHFgLouYABT1_hG6nOYZyXqG04kK2am_IDpSLU0oRVw_LMDD79MwhPVPSM_v0zG2ZOfv3ioeJP3EVgB-AVKSwxvj366ddfwNwkacO</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Hoang, Thi Kieu Hau</creator><creator>Kim, Young Kook</creator><creator>Jeoung, Jin Wook</creator><creator>Park, Ki Ho</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8137-8843</orcidid></search><sort><creationdate>20180801</creationdate><title>Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C</title><author>Hoang, Thi Kieu Hau ; Kim, Young Kook ; Jeoung, Jin Wook ; Park, Ki Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-a312763eeb6465fd462288ae11a61a56826277e68d50c99cdab78c4d9864688b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/499</topic><topic>692/699/3161/3169/3170</topic><topic>692/700/1750</topic><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Age groups</topic><topic>Aged</topic><topic>Alkylating Agents - administration & dosage</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Glaucoma, Open-Angle - surgery</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intraocular Pressure - physiology</topic><topic>Intraoperative Period</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mitomycin - administration & dosage</topic><topic>Mitomycin C</topic><topic>Morphology</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Success</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Time Factors</topic><topic>Trabeculectomy - methods</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoang, Thi Kieu Hau</creatorcontrib><creatorcontrib>Kim, Young Kook</creatorcontrib><creatorcontrib>Jeoung, Jin Wook</creatorcontrib><creatorcontrib>Park, Ki Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoang, Thi Kieu Hau</au><au>Kim, Young Kook</au><au>Jeoung, Jin Wook</au><au>Park, Ki Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>32</volume><issue>8</issue><spage>1321</spage><epage>1328</epage><pages>1321-1328</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Purpose
To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC).
Methods
A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old,
n
= 85) and group 2 ( > 60 years old,
n
= 58). Kaplan–Meier survival curve analysis was used to assess long-term surgical success according to “complete success” (intraocular pressure (IOP) reduction ≥ 30% without medications) and “qualified success” criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months.
Results
The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (
p
< 0.001 and
p
= 0.01, respectively). Age and preoperative anti-glaucoma medications were the factors related to complete success (
p
= 0.001). Also, there were significant differences in height, extent and vascularity of bleb between the two groups (
p
= 0.038,
p
= 0.002 and
p
= 0.006, respectively).
Conclusion
The long-term surgical outcome after trabeculectomy with MMC was better in the younger-age group than in the older-age group. Specifically, the younger-age group showed a more prominent and more localized bleb with less vascularity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29581522</pmid><doi>10.1038/s41433-018-0071-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8137-8843</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 2018-08, Vol.32 (8), p.1321-1328 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6085316 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | 692/499 692/699/3161/3169/3170 692/700/1750 Administration, Topical Adolescent Adult Age Distribution Age Factors Age groups Aged Alkylating Agents - administration & dosage Child Child, Preschool Female Follow-Up Studies Glaucoma Glaucoma, Open-Angle - physiopathology Glaucoma, Open-Angle - surgery Humans Incidence Intraocular Pressure - physiology Intraoperative Period Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged Mitomycin - administration & dosage Mitomycin C Morphology Ophthalmology Pharmaceutical Sciences/Technology Postoperative Complications - epidemiology Postoperative Complications - prevention & control Republic of Korea - epidemiology Retrospective Studies Success Surgery Surgical Oncology Time Factors Trabeculectomy - methods Treatment Outcome Visual Acuity Young Adult |
| title | Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C |
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